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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GIRK4
Full Name:
G protein-activated inward rectifier potassium channel 4
Alias:
Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K channel Kir3.4; Inward rectifier K(+) channel Kir3.4; IRK5; KATP1; KATP-1; KCNJ5; Kir3.4; Potassium channel, inwardly rectifying subfamily J member 5; Potassium channel, inwardly rectifying, subfamily J, member 5; Potassium inwardly-rectifying channel, subfamily J, member 5
Type:
Channel, potassium
Mass (Da):
47669
Number AA:
419
UniProt ID:
P48544
International Prot ID:
IPI00298865
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0015467
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
Q
D
M
E
I
G
V
T
P
W
D
P
K
K
I
Site 2
Y32
I
P
K
Q
A
R
D
Y
V
P
I
A
T
D
R
Site 3
T37
R
D
Y
V
P
I
A
T
D
R
T
R
L
L
A
Site 4
Y53
G
K
K
P
R
Q
R
Y
M
E
K
S
G
K
C
Site 5
T70
H
H
G
N
V
Q
E
T
Y
R
Y
L
S
D
L
Site 6
Y71
H
G
N
V
Q
E
T
Y
R
Y
L
S
D
L
F
Site 7
Y73
N
V
Q
E
T
Y
R
Y
L
S
D
L
F
T
T
Site 8
S75
Q
E
T
Y
R
Y
L
S
D
L
F
T
T
L
V
Site 9
T79
R
Y
L
S
D
L
F
T
T
L
V
D
L
K
W
Site 10
T80
Y
L
S
D
L
F
T
T
L
V
D
L
K
W
R
Site 11
T158
G
Y
G
F
R
V
I
T
E
K
C
P
E
G
I
Site 12
S191
G
C
M
F
V
K
I
S
Q
P
K
K
R
A
E
Site 13
T199
Q
P
K
K
R
A
E
T
L
M
F
S
N
N
A
Site 14
S209
F
S
N
N
A
V
I
S
M
R
D
E
K
L
C
Site 15
S227
R
V
G
D
L
R
N
S
H
I
V
E
A
S
I
Site 16
S233
N
S
H
I
V
E
A
S
I
R
A
K
L
I
K
Site 17
S241
I
R
A
K
L
I
K
S
R
Q
T
K
E
G
E
Site 18
T244
K
L
I
K
S
R
Q
T
K
E
G
E
F
I
P
Site 19
T263
D
I
N
V
G
F
D
T
G
D
D
R
L
F
L
Site 20
S284
S
H
E
I
N
E
K
S
P
F
W
E
M
S
Q
Site 21
S290
K
S
P
F
W
E
M
S
Q
A
Q
L
H
Q
E
Site 22
S321
M
T
C
Q
A
R
S
S
Y
M
D
T
E
V
L
Site 23
Y322
T
C
Q
A
R
S
S
Y
M
D
T
E
V
L
W
Site 24
T325
A
R
S
S
Y
M
D
T
E
V
L
W
G
H
R
Site 25
T338
H
R
F
T
P
V
L
T
L
E
K
G
F
Y
E
Site 26
Y344
L
T
L
E
K
G
F
Y
E
V
D
Y
N
T
F
Site 27
Y348
K
G
F
Y
E
V
D
Y
N
T
F
H
D
T
Y
Site 28
T354
D
Y
N
T
F
H
D
T
Y
E
T
N
T
P
S
Site 29
Y355
Y
N
T
F
H
D
T
Y
E
T
N
T
P
S
C
Site 30
T359
H
D
T
Y
E
T
N
T
P
S
C
C
A
K
E
Site 31
S361
T
Y
E
T
N
T
P
S
C
C
A
K
E
L
A
Site 32
Y379
R
E
G
R
L
L
Q
Y
L
P
S
P
P
L
L
Site 33
S412
E
P
K
G
L
G
G
S
R
E
A
R
G
S
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation