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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cx50
Full Name:
Gap junction alpha-8 protein
Alias:
CAE; CAE1; Connexin 50; Connexin-50; CXA8; CZP1; Gap junction protein, alpha 8, 50kDa; GJA8; Lens fiber protein MP70
Type:
Adhesion protein
Mass (Da):
48229
Number AA:
433
UniProt ID:
P48165
International Prot ID:
IPI00220287
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005922
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0015267
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0006810
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y66
P
G
C
E
N
V
C
Y
D
E
A
F
P
I
S
Site 2
Y99
Y
V
G
H
A
V
H
Y
V
R
M
E
E
K
R
Site 3
S108
R
M
E
E
K
R
K
S
R
E
A
E
E
L
G
Site 4
S128
N
G
G
P
D
Q
G
S
V
K
K
S
S
G
S
Site 5
S132
D
Q
G
S
V
K
K
S
S
G
S
K
G
T
K
Site 6
S133
Q
G
S
V
K
K
S
S
G
S
K
G
T
K
K
Site 7
S135
S
V
K
K
S
S
G
S
K
G
T
K
K
F
R
Site 8
T138
K
S
S
G
S
K
G
T
K
K
F
R
L
E
G
Site 9
T146
K
K
F
R
L
E
G
T
L
L
R
T
Y
I
C
Site 10
Y181
G
F
R
I
L
P
L
Y
R
C
S
R
W
P
C
Site 11
S234
L
G
L
K
G
I
R
S
A
L
K
R
P
V
E
Site 12
S258
L
H
S
I
A
V
S
S
I
Q
K
A
K
G
Y
Site 13
S259
L
H
S
I
A
V
S
S
I
Q
K
A
K
G
Y
Site 14
S276
L
E
E
E
K
I
V
S
H
Y
F
P
L
T
E
Site 15
Y278
E
E
K
I
V
S
H
Y
F
P
L
T
E
V
G
Site 16
S290
E
V
G
M
V
E
T
S
P
L
P
A
K
P
F
Site 17
S305
N
Q
F
E
E
K
I
S
T
G
P
L
G
D
L
Site 18
T306
Q
F
E
E
K
I
S
T
G
P
L
G
D
L
S
Site 19
S313
T
G
P
L
G
D
L
S
R
G
Y
Q
E
T
L
Site 20
Y316
L
G
D
L
S
R
G
Y
Q
E
T
L
P
S
Y
Site 21
T319
L
S
R
G
Y
Q
E
T
L
P
S
Y
A
Q
V
Site 22
S322
G
Y
Q
E
T
L
P
S
Y
A
Q
V
G
A
Q
Site 23
Y323
Y
Q
E
T
L
P
S
Y
A
Q
V
G
A
Q
E
Site 24
T357
K
E
E
A
E
R
L
T
T
E
E
Q
E
K
V
Site 25
T358
E
E
A
E
R
L
T
T
E
E
Q
E
K
V
A
Site 26
T374
P
E
G
E
K
V
E
T
P
G
V
D
K
E
G
Site 27
S388
G
E
K
E
E
P
Q
S
E
K
V
S
K
Q
G
Site 28
S392
E
P
Q
S
E
K
V
S
K
Q
G
L
P
A
E
Site 29
T401
Q
G
L
P
A
E
K
T
P
S
L
C
P
E
L
Site 30
S403
L
P
A
E
K
T
P
S
L
C
P
E
L
T
T
Site 31
T409
P
S
L
C
P
E
L
T
T
D
D
A
R
P
L
Site 32
S417
T
D
D
A
R
P
L
S
R
L
S
K
A
S
S
Site 33
S420
A
R
P
L
S
R
L
S
K
A
S
S
R
A
R
Site 34
S423
L
S
R
L
S
K
A
S
S
R
A
R
S
D
D
Site 35
S424
S
R
L
S
K
A
S
S
R
A
R
S
D
D
L
Site 36
S428
K
A
S
S
R
A
R
S
D
D
L
T
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation