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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIR
Full Name:
Inward rectifier potassium channel 4
Alias:
Hippocampal inward rectifier; HIRK2; HRK1; Inward rectifier K channel Kir2.3; Inward rectifier K(+) channel Kir2.3; IRK3; IRK4; KCNJ4; Kir2.3; Potassium channel, inwardly rectifying subfamily J member 4; Potassium channel, inwardly rectifying, subfamily J, member 4; Potassium inwardly-rectifying channel, subfamily J, member 4
Type:
Channel, potassium
Mass (Da):
49500
Number AA:
445
UniProt ID:
P48050
International Prot ID:
IPI00007626
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005242
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Inward rectifier potassium channel 4 pan-specific antibody AB-NN279-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN279-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y31
K
N
G
Q
C
N
V
Y
F
A
N
L
S
N
K
Site 2
S39
F
A
N
L
S
N
K
S
Q
R
Y
M
A
D
I
Site 3
T53
I
F
T
T
C
V
D
T
R
W
R
Y
M
L
M
Site 4
S90
F
H
G
D
L
E
A
S
P
G
V
P
A
A
G
Site 5
T134
F
S
V
E
T
Q
T
T
I
G
Y
G
F
R
C
Site 6
T184
R
P
K
K
R
A
Q
T
L
L
F
S
H
H
A
Site 7
S212
R
V
G
N
L
R
K
S
H
I
V
E
A
H
V
Site 8
Y227
R
A
Q
L
I
K
P
Y
M
T
Q
E
G
E
Y
Site 9
T229
Q
L
I
K
P
Y
M
T
Q
E
G
E
Y
L
P
Site 10
Y234
Y
M
T
Q
E
G
E
Y
L
P
L
D
Q
R
D
Site 11
S269
V
H
E
I
D
E
D
S
P
L
Y
G
M
G
K
Site 12
Y272
I
D
E
D
S
P
L
Y
G
M
G
K
E
E
L
Site 13
S281
M
G
K
E
E
L
E
S
E
D
F
E
I
V
V
Site 14
T301
V
E
A
T
A
M
T
T
Q
A
R
S
S
Y
L
Site 15
S306
M
T
T
Q
A
R
S
S
Y
L
A
S
E
I
L
Site 16
Y307
T
T
Q
A
R
S
S
Y
L
A
S
E
I
L
W
Site 17
S310
A
R
S
S
Y
L
A
S
E
I
L
W
G
H
R
Site 18
S327
P
V
V
F
E
E
K
S
H
Y
K
V
D
Y
S
Site 19
Y329
V
F
E
E
K
S
H
Y
K
V
D
Y
S
R
F
Site 20
Y333
K
S
H
Y
K
V
D
Y
S
R
F
H
K
T
Y
Site 21
Y340
Y
S
R
F
H
K
T
Y
E
V
A
G
T
P
C
Site 22
T345
K
T
Y
E
V
A
G
T
P
C
C
S
A
R
E
Site 23
S349
V
A
G
T
P
C
C
S
A
R
E
L
Q
E
S
Site 24
S356
S
A
R
E
L
Q
E
S
K
I
T
V
L
P
A
Site 25
T359
E
L
Q
E
S
K
I
T
V
L
P
A
P
P
P
Site 26
S369
P
A
P
P
P
P
P
S
A
F
C
Y
E
N
E
Site 27
Y373
P
P
P
S
A
F
C
Y
E
N
E
L
A
L
M
Site 28
S381
E
N
E
L
A
L
M
S
Q
E
E
E
E
M
E
Site 29
S421
I
R
M
L
E
F
G
S
H
L
D
L
E
R
M
Site 30
S438
S
L
P
L
D
N
I
S
Y
R
R
E
S
A
I
Site 31
Y439
L
P
L
D
N
I
S
Y
R
R
E
S
A
I
_
Site 32
S443
N
I
S
Y
R
R
E
S
A
I
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation