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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XDH
Full Name:
Xanthine dehydrogenase/oxidase
Alias:
EC 1.17.1.4; EC 1.17.3.2; Xanthine oxidase; Xanthine oxidoreductase; XO; XOR
Type:
Enzyme, oxidoreductase, nucleotide metabolism group, purine metabolism family
Mass (Da):
146424
Number AA:
1333
UniProt ID:
P47989
International Prot ID:
IPI00244391
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0051537
GO:0050660
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y29
P
E
T
T
L
L
A
Y
L
R
R
K
L
G
L
Site 2
S37
L
R
R
K
L
G
L
S
G
T
K
L
G
C
G
Site 3
T39
R
K
L
G
L
S
G
T
K
L
G
C
G
E
G
Site 4
Y58
C
T
V
M
L
S
K
Y
D
R
L
Q
N
K
I
Site 5
S93
T
T
V
E
G
I
G
S
T
K
T
R
L
H
P
Site 6
S108
V
Q
E
R
I
A
K
S
H
G
S
Q
C
G
F
Site 7
S111
R
I
A
K
S
H
G
S
Q
C
G
F
C
T
P
Site 8
T151
Q
G
N
L
C
R
C
T
G
Y
R
P
I
L
Q
Site 9
T162
P
I
L
Q
G
F
R
T
F
A
R
D
G
G
C
Site 10
S188
M
N
Q
K
K
D
H
S
V
S
L
S
P
S
L
Site 11
S190
Q
K
K
D
H
S
V
S
L
S
P
S
L
F
K
Site 12
S192
K
D
H
S
V
S
L
S
P
S
L
F
K
P
E
Site 13
S194
H
S
V
S
L
S
P
S
L
F
K
P
E
E
F
Site 14
T202
L
F
K
P
E
E
F
T
P
L
D
P
T
Q
E
Site 15
T207
E
F
T
P
L
D
P
T
Q
E
P
I
F
P
P
Site 16
T222
E
L
L
R
L
K
D
T
P
R
K
Q
L
R
F
Site 17
T235
R
F
E
G
E
R
V
T
W
I
Q
A
S
T
L
Site 18
S240
R
V
T
W
I
Q
A
S
T
L
K
E
L
L
D
Site 19
S289
A
W
I
P
E
L
N
S
V
E
H
G
P
D
G
Site 20
T311
P
L
S
I
V
E
K
T
L
V
D
A
V
A
K
Site 21
T324
A
K
L
P
A
Q
K
T
E
V
F
R
G
V
L
Site 22
S344
F
A
G
K
Q
V
K
S
V
A
S
V
G
G
N
Site 23
T373
M
A
S
G
A
K
L
T
L
V
S
R
G
T
R
Site 24
T379
L
T
L
V
S
R
G
T
R
R
T
V
Q
M
D
Site 25
T382
V
S
R
G
T
R
R
T
V
Q
M
D
H
T
F
Site 26
T388
R
T
V
Q
M
D
H
T
F
F
P
G
Y
R
K
Site 27
Y393
D
H
T
F
F
P
G
Y
R
K
T
L
L
S
P
Site 28
T396
F
F
P
G
Y
R
K
T
L
L
S
P
E
E
I
Site 29
S399
G
Y
R
K
T
L
L
S
P
E
E
I
L
L
S
Site 30
S406
S
P
E
E
I
L
L
S
I
E
I
P
Y
S
R
Site 31
Y411
L
L
S
I
E
I
P
Y
S
R
E
G
E
Y
F
Site 32
S412
L
S
I
E
I
P
Y
S
R
E
G
E
Y
F
S
Site 33
Y417
P
Y
S
R
E
G
E
Y
F
S
A
F
K
Q
A
Site 34
S419
S
R
E
G
E
Y
F
S
A
F
K
Q
A
S
R
Site 35
S425
F
S
A
F
K
Q
A
S
R
R
E
D
D
I
A
Site 36
T446
R
V
L
F
K
P
G
T
T
E
V
Q
E
L
A
Site 37
S465
G
M
A
N
R
T
I
S
A
L
K
T
T
Q
R
Site 38
T469
R
T
I
S
A
L
K
T
T
Q
R
Q
L
S
K
Site 39
T470
T
I
S
A
L
K
T
T
Q
R
Q
L
S
K
L
Site 40
S475
K
T
T
Q
R
Q
L
S
K
L
W
K
E
E
L
Site 41
Y593
Q
A
S
G
E
A
V
Y
C
D
D
I
P
R
Y
Site 42
Y600
Y
C
D
D
I
P
R
Y
E
N
E
L
S
L
R
Site 43
S605
P
R
Y
E
N
E
L
S
L
R
L
V
T
S
T
Site 44
T610
E
L
S
L
R
L
V
T
S
T
R
A
H
A
K
Site 45
T612
S
L
R
L
V
T
S
T
R
A
H
A
K
I
K
Site 46
S620
R
A
H
A
K
I
K
S
I
D
T
S
E
A
K
Site 47
S624
K
I
K
S
I
D
T
S
E
A
K
K
V
P
G
Site 48
S644
S
A
D
D
V
P
G
S
N
I
T
G
I
C
N
Site 49
T654
T
G
I
C
N
D
E
T
V
F
A
K
D
K
V
Site 50
T675
I
G
A
V
V
A
D
T
P
E
H
T
Q
R
A
Site 51
S707
E
D
A
I
K
N
N
S
F
Y
G
P
E
L
K
Site 52
Y709
A
I
K
N
N
S
F
Y
G
P
E
L
K
I
E
Site 53
S725
G
D
L
K
K
G
F
S
E
A
D
N
V
V
S
Site 54
S732
S
E
A
D
N
V
V
S
G
E
I
Y
I
G
G
Site 55
Y736
N
V
V
S
G
E
I
Y
I
G
G
Q
E
H
F
Site 56
Y744
I
G
G
Q
E
H
F
Y
L
E
T
H
C
T
I
Site 57
S766
G
E
M
E
L
F
V
S
T
Q
N
T
M
K
T
Site 58
T770
L
F
V
S
T
Q
N
T
M
K
T
Q
S
F
V
Site 59
T773
S
T
Q
N
T
M
K
T
Q
S
F
V
A
K
M
Site 60
S775
Q
N
T
M
K
T
Q
S
F
V
A
K
M
L
G
Site 61
S806
F
G
G
K
E
T
R
S
T
V
V
S
T
A
V
Site 62
T807
G
G
K
E
T
R
S
T
V
V
S
T
A
V
A
Site 63
Y818
T
A
V
A
L
A
A
Y
K
T
G
R
P
V
R
Site 64
T837
R
D
E
D
M
L
I
T
G
G
R
H
P
F
L
Site 65
Y847
R
H
P
F
L
A
R
Y
K
V
G
F
M
K
T
Site 66
T856
V
G
F
M
K
T
G
T
V
V
A
L
E
V
D
Site 67
S866
A
L
E
V
D
H
F
S
N
V
G
N
T
Q
D
Site 68
S875
V
G
N
T
Q
D
L
S
Q
S
I
M
E
R
A
Site 69
Y890
L
F
H
M
D
N
C
Y
K
I
P
N
I
R
G
Site 70
T898
K
I
P
N
I
R
G
T
G
R
L
C
K
T
N
Site 71
T904
G
T
G
R
L
C
K
T
N
L
P
S
N
T
A
Site 72
Y948
E
V
R
R
K
N
L
Y
K
E
G
D
L
T
H
Site 73
T954
L
Y
K
E
G
D
L
T
H
F
N
Q
K
L
E
Site 74
Y978
E
C
L
A
S
S
Q
Y
H
A
R
K
S
E
V
Site 75
S983
S
Q
Y
H
A
R
K
S
E
V
D
K
F
N
K
Site 76
T1033
T
D
G
S
V
L
L
T
H
G
G
T
E
M
G
Site 77
S1060
R
A
L
K
I
P
T
S
K
I
Y
I
S
E
T
Site 78
Y1063
K
I
P
T
S
K
I
Y
I
S
E
T
S
T
N
Site 79
T1069
I
Y
I
S
E
T
S
T
N
T
V
P
N
T
S
Site 80
T1071
I
S
E
T
S
T
N
T
V
P
N
T
S
P
T
Site 81
S1076
T
N
T
V
P
N
T
S
P
T
A
A
S
V
S
Site 82
T1078
T
V
P
N
T
S
P
T
A
A
S
V
S
A
D
Site 83
S1081
N
T
S
P
T
A
A
S
V
S
A
D
L
N
G
Site 84
Y1092
D
L
N
G
Q
A
V
Y
A
A
C
Q
T
I
L
Site 85
S1113
K
K
K
N
P
S
G
S
W
E
D
W
V
T
A
Site 86
S1129
Y
M
D
T
V
S
L
S
A
T
G
F
Y
R
T
Site 87
T1131
D
T
V
S
L
S
A
T
G
F
Y
R
T
P
N
Site 88
Y1134
S
L
S
A
T
G
F
Y
R
T
P
N
L
G
Y
Site 89
T1136
S
A
T
G
F
Y
R
T
P
N
L
G
Y
S
F
Site 90
S1142
R
T
P
N
L
G
Y
S
F
E
T
N
S
G
N
Site 91
Y1153
N
S
G
N
P
F
H
Y
F
S
Y
G
V
A
C
Site 92
T1169
E
V
E
I
D
C
L
T
G
D
H
K
N
L
R
Site 93
Y1214
F
T
L
E
E
L
H
Y
S
P
E
G
S
L
H
Site 94
S1215
T
L
E
E
L
H
Y
S
P
E
G
S
L
H
T
Site 95
S1219
L
H
Y
S
P
E
G
S
L
H
T
R
G
P
S
Site 96
T1222
S
P
E
G
S
L
H
T
R
G
P
S
T
Y
K
Site 97
S1226
S
L
H
T
R
G
P
S
T
Y
K
I
P
A
F
Site 98
Y1228
H
T
R
G
P
S
T
Y
K
I
P
A
F
G
S
Site 99
S1299
K
E
L
F
R
L
D
S
P
A
T
P
E
K
I
Site 100
T1302
F
R
L
D
S
P
A
T
P
E
K
I
R
N
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation