KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PLA2G4A
Full Name:
Cytosolic phospholipase A2
Alias:
CPLA2; CPLA2-alpha; PA24; PA24A; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4
Type:
Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid; EC 3.1.1.4; Phospholipase; EC 3.1.1.5; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - alpha-linolenic acid
Mass (Da):
85211
Number AA:
749
UniProt ID:
P47712
International Prot ID:
IPI00026108
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016021
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004622
GO:0004620
PhosphoSite+
KinaseNET
Biological Process:
GO:0009395
GO:0006663
GO:0006631
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
S
F
I
D
P
Y
Q
H
I
I
V
E
H
Site 2
T21
H
Q
Y
S
H
K
F
T
V
V
V
L
R
A
T
Site 3
T31
V
L
R
A
T
K
V
T
K
G
A
F
G
D
M
Site 4
T41
A
F
G
D
M
L
D
T
P
D
P
Y
V
E
L
Site 5
S51
P
Y
V
E
L
F
I
S
T
T
P
D
S
R
K
Site 6
T53
V
E
L
F
I
S
T
T
P
D
S
R
K
R
T
Site 7
S56
F
I
S
T
T
P
D
S
R
K
R
T
R
H
F
Site 8
T60
T
P
D
S
R
K
R
T
R
H
F
N
N
D
I
Site 9
T106
D
E
T
L
G
T
A
T
F
T
V
S
S
M
K
Site 10
S147
S
C
P
D
L
R
F
S
M
A
L
C
D
Q
E
Site 11
T156
A
L
C
D
Q
E
K
T
F
R
Q
Q
R
K
E
Site 12
S168
R
K
E
H
I
R
E
S
M
K
K
L
L
G
P
Site 13
S178
K
L
L
G
P
K
N
S
E
G
L
H
S
A
R
Site 14
S183
K
N
S
E
G
L
H
S
A
R
D
V
P
V
V
Site 15
S228
A
T
Y
V
A
G
L
S
G
S
T
W
Y
M
S
Site 16
Y233
G
L
S
G
S
T
W
Y
M
S
T
L
Y
S
H
Site 17
S235
S
G
S
T
W
Y
M
S
T
L
Y
S
H
P
D
Site 18
Y238
T
W
Y
M
S
T
L
Y
S
H
P
D
F
P
E
Site 19
T268
H
N
P
L
L
L
L
T
P
Q
K
V
K
R
Y
Site 20
Y275
T
P
Q
K
V
K
R
Y
V
E
S
L
W
K
K
Site 21
S278
K
V
K
R
Y
V
E
S
L
W
K
K
K
S
S
Site 22
S284
E
S
L
W
K
K
K
S
S
G
Q
P
V
T
F
Site 23
T290
K
S
S
G
Q
P
V
T
F
T
D
I
F
G
M
Site 24
T310
L
I
H
N
R
M
N
T
T
L
S
S
L
K
E
Site 25
T321
S
L
K
E
K
V
N
T
A
Q
C
P
L
P
L
Site 26
Y352
D
W
V
E
F
S
P
Y
E
I
G
M
A
K
Y
Site 27
Y359
Y
E
I
G
M
A
K
Y
G
T
F
M
A
P
D
Site 28
T376
G
S
K
F
F
M
G
T
V
V
K
K
Y
E
E
Site 29
Y381
M
G
T
V
V
K
K
Y
E
E
N
P
L
H
F
Site 30
S408
F
N
R
V
L
G
V
S
G
S
Q
S
R
G
S
Site 31
S410
R
V
L
G
V
S
G
S
Q
S
R
G
S
T
M
Site 32
S412
L
G
V
S
G
S
Q
S
R
G
S
T
M
E
E
Site 33
S415
S
G
S
Q
S
R
G
S
T
M
E
E
E
L
E
Site 34
T416
G
S
Q
S
R
G
S
T
M
E
E
E
L
E
N
Site 35
T426
E
E
L
E
N
I
T
T
K
H
I
V
S
N
D
Site 36
S431
I
T
T
K
H
I
V
S
N
D
S
S
D
S
D
Site 37
S434
K
H
I
V
S
N
D
S
S
D
S
D
D
E
S
Site 38
S435
H
I
V
S
N
D
S
S
D
S
D
D
E
S
H
Site 39
S437
V
S
N
D
S
S
D
S
D
D
E
S
H
E
P
Site 40
S441
S
S
D
S
D
D
E
S
H
E
P
K
G
T
E
Site 41
T447
E
S
H
E
P
K
G
T
E
N
E
D
A
G
S
Site 42
S454
T
E
N
E
D
A
G
S
D
Y
Q
S
D
N
Q
Site 43
Y456
N
E
D
A
G
S
D
Y
Q
S
D
N
Q
A
S
Site 44
S458
D
A
G
S
D
Y
Q
S
D
N
Q
A
S
W
I
Site 45
Y502
G
L
N
L
N
T
S
Y
P
L
S
P
L
S
D
Site 46
S505
L
N
T
S
Y
P
L
S
P
L
S
D
F
A
T
Site 47
S508
S
Y
P
L
S
P
L
S
D
F
A
T
Q
D
S
Site 48
T512
S
P
L
S
D
F
A
T
Q
D
S
F
D
D
D
Site 49
S515
S
D
F
A
T
Q
D
S
F
D
D
D
E
L
D
Site 50
Y535
P
D
E
F
E
R
I
Y
E
P
L
D
V
K
S
Site 51
S577
L
I
I
S
F
D
F
S
A
R
P
S
D
S
S
Site 52
S581
F
D
F
S
A
R
P
S
D
S
S
P
P
F
K
Site 53
S583
F
S
A
R
P
S
D
S
S
P
P
F
K
E
L
Site 54
S584
S
A
R
P
S
D
S
S
P
P
F
K
E
L
L
Site 55
Y610
P
F
P
K
I
D
P
Y
V
F
D
R
E
G
L
Site 56
Y621
R
E
G
L
K
E
C
Y
V
F
K
P
K
N
P
Site 57
Y650
A
N
I
N
F
R
K
Y
K
A
P
G
V
P
R
Site 58
T659
A
P
G
V
P
R
E
T
E
E
E
K
E
I
A
Site 59
S676
D
I
F
D
D
P
E
S
P
F
S
T
F
N
F
Site 60
S679
D
D
P
E
S
P
F
S
T
F
N
F
Q
Y
P
Site 61
T680
D
P
E
S
P
F
S
T
F
N
F
Q
Y
P
N
Site 62
Y685
F
S
T
F
N
F
Q
Y
P
N
Q
A
F
K
R
Site 63
Y718
A
M
V
E
S
I
E
Y
R
R
Q
N
P
S
R
Site 64
S724
E
Y
R
R
Q
N
P
S
R
C
S
V
S
L
S
Site 65
S727
R
Q
N
P
S
R
C
S
V
S
L
S
N
V
E
Site 66
S729
N
P
S
R
C
S
V
S
L
S
N
V
E
A
R
Site 67
S731
S
R
C
S
V
S
L
S
N
V
E
A
R
R
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation