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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
p27Kip1
Full Name:
Cyclin-dependent kinase inhibitor 1B
Alias:
Cyclin-dependent kinase inhibitor p27;p27Kip1
Type:
Cell cycle protein, inhibitor
Mass (Da):
22073
Number AA:
198
UniProt ID:
P46527
International Prot ID:
IPI00006991
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004861
GO:0005515
GO:0005072
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0048102
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
N
V
R
V
S
N
G
S
P
S
L
E
Site 2
S10
N
V
R
V
S
N
G
S
P
S
L
E
R
M
D
Site 3
S12
R
V
S
N
G
S
P
S
L
E
R
M
D
A
R
Site 4
Y74
H
K
P
L
E
G
K
Y
E
W
Q
E
V
E
K
Site 5
S83
W
Q
E
V
E
K
G
S
L
P
E
F
Y
Y
R
Site 6
Y88
K
G
S
L
P
E
F
Y
Y
R
P
P
R
P
P
Site 7
Y89
G
S
L
P
E
F
Y
Y
R
P
P
R
P
P
K
Site 8
S106
C
K
V
P
A
Q
E
S
Q
D
V
S
G
S
R
Site 9
S110
A
Q
E
S
Q
D
V
S
G
S
R
P
A
A
P
Site 10
S112
E
S
Q
D
V
S
G
S
R
P
A
A
P
L
I
Site 11
T135
T
H
L
V
D
P
K
T
D
P
S
D
S
Q
T
Site 12
S138
V
D
P
K
T
D
P
S
D
S
Q
T
G
L
A
Site 13
S140
P
K
T
D
P
S
D
S
Q
T
G
L
A
E
Q
Site 14
T142
T
D
P
S
D
S
Q
T
G
L
A
E
Q
C
A
Site 15
T157
G
I
R
K
R
P
A
T
D
D
S
S
T
Q
N
Site 16
S161
R
P
A
T
D
D
S
S
T
Q
N
K
R
A
N
Site 17
T162
P
A
T
D
D
S
S
T
Q
N
K
R
A
N
R
Site 18
S175
N
R
T
E
E
N
V
S
D
G
S
P
N
A
G
Site 19
S178
E
E
N
V
S
D
G
S
P
N
A
G
S
V
E
Site 20
S183
D
G
S
P
N
A
G
S
V
E
Q
T
P
K
K
Site 21
T187
N
A
G
S
V
E
Q
T
P
K
K
P
G
L
R
Site 22
T198
P
G
L
R
R
R
Q
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation