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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOL1
Full Name:
Putative ribosomal RNA methyltransferase NOP2
Alias:
NOL1/NOP2/Sun domain family, member 1; NOP120; NOP2 nucleolar protein; NSUN1; p120; Proliferating-cell nucleolar antigen p120; Proliferation-associated nucleolar protein p120
Type:
EC 2.1.1.-; Methyltransferase; Cell cycle regulation
Mass (Da):
89302
Number AA:
812
UniProt ID:
P46087
International Prot ID:
IPI00294891
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0008757
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008284
GO:0006364
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
G
R
K
L
D
P
T
K
E
K
R
G
P
G
Site 2
S36
V
R
F
L
P
A
V
S
D
E
N
S
K
R
L
Site 3
S40
P
A
V
S
D
E
N
S
K
R
L
S
S
R
A
Site 4
S44
D
E
N
S
K
R
L
S
S
R
A
R
K
R
A
Site 5
S45
E
N
S
K
R
L
S
S
R
A
R
K
R
A
A
Site 6
S58
A
A
K
R
R
L
G
S
V
E
A
P
K
T
N
Site 7
T64
G
S
V
E
A
P
K
T
N
K
S
P
E
A
K
Site 8
S67
E
A
P
K
T
N
K
S
P
E
A
K
P
L
P
Site 9
S96
A
G
K
K
G
P
Q
S
L
F
N
A
P
R
G
Site 10
S111
K
K
R
P
A
P
G
S
D
E
E
E
E
E
E
Site 11
S120
E
E
E
E
E
E
D
S
E
E
D
G
M
V
N
Site 12
S134
N
H
G
D
L
W
G
S
E
D
D
A
D
T
V
Site 13
T140
G
S
E
D
D
A
D
T
V
D
D
Y
G
A
D
Site 14
Y144
D
A
D
T
V
D
D
Y
G
A
D
S
N
S
E
Site 15
S148
V
D
D
Y
G
A
D
S
N
S
E
D
E
E
E
Site 16
S150
D
Y
G
A
D
S
N
S
E
D
E
E
E
G
E
Site 17
S181
A
A
A
G
I
Q
W
S
E
E
E
T
E
D
E
Site 18
T185
I
Q
W
S
E
E
E
T
E
D
E
E
E
E
K
Site 19
T195
E
E
E
E
K
E
V
T
P
E
S
G
P
P
K
Site 20
S198
E
K
E
V
T
P
E
S
G
P
P
K
V
E
E
Site 21
S262
A
Q
R
E
E
G
R
S
R
S
E
Y
L
N
R
Site 22
S264
R
E
E
G
R
S
R
S
E
Y
L
N
R
L
K
Site 23
Y266
E
G
R
S
R
S
E
Y
L
N
R
L
K
K
D
Site 24
Y277
L
K
K
D
L
A
I
Y
Y
S
Y
G
D
F
L
Site 25
T311
N
E
V
P
R
P
V
T
L
R
T
N
T
L
K
Site 26
T316
P
V
T
L
R
T
N
T
L
K
T
R
R
R
D
Site 27
T319
L
R
T
N
T
L
K
T
R
R
R
D
L
A
Q
Site 28
T344
P
L
G
K
W
S
K
T
G
L
V
V
Y
D
S
Site 29
T358
S
S
V
P
I
G
A
T
P
E
Y
L
A
G
H
Site 30
Y401
A
P
G
G
K
T
S
Y
M
A
Q
L
M
K
N
Site 31
S424
A
N
A
E
R
L
K
S
V
V
G
N
L
H
R
Site 32
Y442
T
N
T
I
I
S
H
Y
D
G
R
Q
F
P
K
Site 33
T505
A
I
D
S
V
N
A
T
S
K
T
G
G
Y
L
Site 34
S506
I
D
S
V
N
A
T
S
K
T
G
G
Y
L
V
Site 35
Y530
E
N
E
W
V
V
D
Y
A
L
K
K
R
N
V
Site 36
S562
R
E
R
R
F
H
P
S
L
R
S
T
R
R
F
Site 37
S565
R
F
H
P
S
L
R
S
T
R
R
F
Y
P
H
Site 38
T566
F
H
P
S
L
R
S
T
R
R
F
Y
P
H
T
Site 39
Y570
L
R
S
T
R
R
F
Y
P
H
T
H
N
M
D
Site 40
S588
I
A
K
F
K
K
F
S
N
S
I
P
Q
S
Q
Site 41
S590
K
F
K
K
F
S
N
S
I
P
Q
S
Q
T
G
Site 42
S594
F
S
N
S
I
P
Q
S
Q
T
G
N
S
E
T
Site 43
T596
N
S
I
P
Q
S
Q
T
G
N
S
E
T
A
T
Site 44
S599
P
Q
S
Q
T
G
N
S
E
T
A
T
P
T
N
Site 45
T603
T
G
N
S
E
T
A
T
P
T
N
V
D
L
P
Site 46
S616
L
P
Q
V
I
P
K
S
E
N
S
S
Q
P
A
Site 47
S619
V
I
P
K
S
E
N
S
S
Q
P
A
K
K
A
Site 48
S620
I
P
K
S
E
N
S
S
Q
P
A
K
K
A
K
Site 49
S646
Q
Q
H
P
K
K
A
S
F
Q
K
L
N
G
I
Site 50
S659
G
I
S
K
G
A
D
S
E
L
S
T
V
P
S
Site 51
S662
K
G
A
D
S
E
L
S
T
V
P
S
V
T
K
Site 52
T663
G
A
D
S
E
L
S
T
V
P
S
V
T
K
T
Site 53
S666
S
E
L
S
T
V
P
S
V
T
K
T
Q
A
S
Site 54
T670
T
V
P
S
V
T
K
T
Q
A
S
S
S
F
Q
Site 55
S673
S
V
T
K
T
Q
A
S
S
S
F
Q
D
S
S
Site 56
S675
T
K
T
Q
A
S
S
S
F
Q
D
S
S
Q
P
Site 57
S679
A
S
S
S
F
Q
D
S
S
Q
P
A
G
K
A
Site 58
S680
S
S
S
F
Q
D
S
S
Q
P
A
G
K
A
E
Site 59
T695
G
I
R
E
P
K
V
T
G
K
L
K
Q
R
S
Site 60
S702
T
G
K
L
K
Q
R
S
P
K
L
Q
S
S
K
Site 61
T723
Q
N
A
P
P
K
G
T
D
T
Q
T
P
A
V
Site 62
T725
A
P
P
K
G
T
D
T
Q
T
P
A
V
L
S
Site 63
T727
P
K
G
T
D
T
Q
T
P
A
V
L
S
P
S
Site 64
S732
T
Q
T
P
A
V
L
S
P
S
K
T
Q
A
T
Site 65
S734
T
P
A
V
L
S
P
S
K
T
Q
A
T
L
K
Site 66
T736
A
V
L
S
P
S
K
T
Q
A
T
L
K
P
K
Site 67
T739
S
P
S
K
T
Q
A
T
L
K
P
K
D
H
H
Site 68
T776
A
F
Q
K
Q
N
D
T
P
K
G
P
Q
P
P
Site 69
T784
P
K
G
P
Q
P
P
T
V
S
P
I
R
S
S
Site 70
S786
G
P
Q
P
P
T
V
S
P
I
R
S
S
R
P
Site 71
S790
P
T
V
S
P
I
R
S
S
R
P
P
P
A
K
Site 72
S791
T
V
S
P
I
R
S
S
R
P
P
P
A
K
R
Site 73
S801
P
P
A
K
R
K
K
S
Q
S
R
G
N
S
Q
Site 74
S803
A
K
R
K
K
S
Q
S
R
G
N
S
Q
L
L
Site 75
S807
K
S
Q
S
R
G
N
S
Q
L
L
L
S
_
_
Site 76
S812
G
N
S
Q
L
L
L
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation