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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRK6
Full Name:
G protein-coupled receptor kinase 6
Alias:
EC 2.7.11.16; GPRK6
Type:
Protein-serine kinase, AGC group, GRK family, GRK subfamily
Mass (Da):
65991
Number AA:
576
UniProt ID:
P43250
International Prot ID:
IPI00017330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004703
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0008277
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
GRKtide KinSub - GRK protein kinase substrate peptide - Powder PE-01ACS95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACS95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Site 2
S40
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
Site 3
S48
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
Site 4
Y53
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
Q
Site 5
S55
S
L
E
R
D
Y
H
S
L
C
E
R
Q
P
I
Site 6
T73
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
Site 7
S78
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
Site 8
T93
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
Site 9
T106
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
Site 10
S111
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
Site 11
T113
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
Site 12
T130
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
Site 13
T149
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
Site 14
Y152
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
Site 15
S154
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
Site 16
Y161
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
Site 17
Y166
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
Site 18
T185
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
Site 19
Y189
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
Site 20
Y212
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
Site 21
Y253
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
Site 22
Y276
G
D
L
K
F
H
I
Y
H
M
G
Q
A
G
F
Site 23
Y309
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
Site 24
S328
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
Site 25
T348
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
Site 26
Y351
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
Site 27
S383
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
Site 28
Y408
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
Site 29
S409
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
Site 30
S413
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
Site 31
S418
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
Site 32
S438
R
L
G
C
R
G
G
S
A
R
E
V
K
E
H
Site 33
Y473
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
Site 34
S484
V
L
D
I
E
Q
F
S
T
V
K
G
V
E
L
Site 35
T485
L
D
I
E
Q
F
S
T
V
K
G
V
E
L
E
Site 36
T494
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
Site 37
Y499
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
Site 38
S532
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
Site 39
S557
G
L
L
Q
R
L
F
S
R
Q
D
C
C
G
N
Site 40
S566
Q
D
C
C
G
N
C
S
D
S
E
E
E
L
P
Site 41
S568
C
C
G
N
C
S
D
S
E
E
E
L
P
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation