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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TEC
Full Name:
Tyrosine-protein kinase Tec
Alias:
EC 2.7.10.2; Kinase Tec; PSCTK4
Type:
Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; TK group; Tec family
Mass (Da):
73581
Number AA:
631
UniProt ID:
P42680
International Prot ID:
IPI00000878
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007243
Phosida
TranscriptoNet
STRING
Kinexus Products
Tyrosine-protein kinase TEC Y519 phosphosite-specific antibody AB-PK829#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK829#Tyrosine-protein kinase Tec (D516-S522, human) pY519 phosphopeptide - Powder PE-04ALH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALH99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
E
I
L
I
K
R
S
Q
Q
K
K
K
T
S
Site 2
S22
S
Q
Q
K
K
K
T
S
P
L
N
Y
K
E
R
Site 3
Y26
K
K
T
S
P
L
N
Y
K
E
R
L
F
V
L
Site 4
T34
K
E
R
L
F
V
L
T
K
S
M
L
T
Y
Y
Site 5
Y40
L
T
K
S
M
L
T
Y
Y
E
G
R
A
E
K
Site 6
Y41
T
K
S
M
L
T
Y
Y
E
G
R
A
E
K
K
Site 7
Y49
E
G
R
A
E
K
K
Y
R
K
G
F
I
D
V
Site 8
Y78
V
I
P
C
Q
N
K
Y
P
F
Q
V
V
H
D
Site 9
T88
Q
V
V
H
D
A
N
T
L
Y
I
F
A
P
S
Site 10
Y90
V
H
D
A
N
T
L
Y
I
F
A
P
S
P
Q
Site 11
S95
T
L
Y
I
F
A
P
S
P
Q
S
R
D
L
W
Site 12
Y130
K
F
W
T
D
G
S
Y
Q
C
C
R
Q
T
E
Site 13
T136
S
Y
Q
C
C
R
Q
T
E
K
L
A
P
G
C
Site 14
Y146
L
A
P
G
C
E
K
Y
N
L
F
E
S
S
I
Site 15
S151
E
K
Y
N
L
F
E
S
S
I
R
K
A
L
P
Site 16
S152
K
Y
N
L
F
E
S
S
I
R
K
A
L
P
P
Site 17
T163
A
L
P
P
A
P
E
T
K
K
R
R
P
P
P
Site 18
S180
P
L
E
E
E
D
N
S
E
E
I
V
V
A
M
Site 19
Y188
E
E
I
V
V
A
M
Y
D
F
Q
A
A
E
G
Site 20
Y206
R
L
E
R
G
Q
E
Y
L
I
L
E
K
N
D
Site 21
Y223
W
W
R
A
R
D
K
Y
G
N
E
G
Y
I
P
Site 22
Y228
D
K
Y
G
N
E
G
Y
I
P
S
N
Y
V
T
Site 23
S231
G
N
E
G
Y
I
P
S
N
Y
V
T
G
K
K
Site 24
Y233
E
G
Y
I
P
S
N
Y
V
T
G
K
K
S
N
Site 25
T235
Y
I
P
S
N
Y
V
T
G
K
K
S
N
N
L
Site 26
Y245
K
S
N
N
L
D
Q
Y
E
W
Y
C
R
N
M
Site 27
S255
Y
C
R
N
M
N
R
S
K
A
E
Q
L
L
R
Site 28
S263
K
A
E
Q
L
L
R
S
E
D
K
E
G
G
F
Site 29
S275
G
G
F
M
V
R
D
S
S
Q
P
G
L
Y
T
Site 30
S276
G
F
M
V
R
D
S
S
Q
P
G
L
Y
T
V
Site 31
Y281
D
S
S
Q
P
G
L
Y
T
V
S
L
Y
T
K
Site 32
T282
S
S
Q
P
G
L
Y
T
V
S
L
Y
T
K
F
Site 33
S284
Q
P
G
L
Y
T
V
S
L
Y
T
K
F
G
G
Site 34
Y286
G
L
Y
T
V
S
L
Y
T
K
F
G
G
E
G
Site 35
S294
T
K
F
G
G
E
G
S
S
G
F
R
H
Y
H
Site 36
S295
K
F
G
G
E
G
S
S
G
F
R
H
Y
H
I
Site 37
Y300
G
S
S
G
F
R
H
Y
H
I
K
E
T
T
T
Site 38
T306
H
Y
H
I
K
E
T
T
T
S
P
K
K
Y
Y
Site 39
S308
H
I
K
E
T
T
T
S
P
K
K
Y
Y
L
A
Site 40
Y312
T
T
T
S
P
K
K
Y
Y
L
A
E
K
H
A
Site 41
Y313
T
T
S
P
K
K
Y
Y
L
A
E
K
H
A
F
Site 42
S322
A
E
K
H
A
F
G
S
I
P
E
I
I
E
Y
Site 43
Y329
S
I
P
E
I
I
E
Y
H
K
H
N
A
A
G
Site 44
Y343
G
L
V
T
R
L
R
Y
P
V
S
V
K
G
K
Site 45
S346
T
R
L
R
Y
P
V
S
V
K
G
K
N
A
P
Site 46
T354
V
K
G
K
N
A
P
T
T
A
G
F
S
Y
E
Site 47
T355
K
G
K
N
A
P
T
T
A
G
F
S
Y
E
K
Site 48
Y360
P
T
T
A
G
F
S
Y
E
K
W
E
I
N
P
Site 49
S368
E
K
W
E
I
N
P
S
E
L
T
F
M
R
E
Site 50
T371
E
I
N
P
S
E
L
T
F
M
R
E
L
G
S
Site 51
Y393
L
G
K
W
R
A
Q
Y
K
V
A
I
K
A
I
Site 52
Y429
H
P
K
L
V
Q
L
Y
G
V
C
T
Q
Q
K
Site 53
Y439
C
T
Q
Q
K
P
I
Y
I
V
T
E
F
M
E
Site 54
S462
R
Q
R
Q
G
H
F
S
R
D
V
L
L
S
M
Site 55
Y479
D
V
C
E
G
M
E
Y
L
E
R
N
S
F
I
Site 56
S484
M
E
Y
L
E
R
N
S
F
I
H
R
D
L
A
Site 57
Y513
S
D
F
G
M
A
R
Y
V
L
D
D
Q
Y
T
Site 58
Y519
R
Y
V
L
D
D
Q
Y
T
S
S
S
G
A
K
Tyrosine-protein kinase TEC Y519 phosphosite-specific antibody AB-PK829#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK829#Tyrosine-protein kinase Tec (D516-S522, human) pY519 phosphopeptide - Powder PE-04ALH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALH99
Site 59
T520
Y
V
L
D
D
Q
Y
T
S
S
S
G
A
K
F
Site 60
S522
L
D
D
Q
Y
T
S
S
S
G
A
K
F
P
V
Site 61
S523
D
D
Q
Y
T
S
S
S
G
A
K
F
P
V
K
Site 62
Y539
C
P
P
E
V
F
N
Y
S
R
F
S
S
K
S
Site 63
S540
P
P
E
V
F
N
Y
S
R
F
S
S
K
S
D
Site 64
S543
V
F
N
Y
S
R
F
S
S
K
S
D
V
W
S
Site 65
S544
F
N
Y
S
R
F
S
S
K
S
D
V
W
S
F
Site 66
S546
Y
S
R
F
S
S
K
S
D
V
W
S
F
G
V
Site 67
S550
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
Site 68
Y569
G
R
M
P
F
E
K
Y
T
N
Y
E
V
V
T
Site 69
Y572
P
F
E
K
Y
T
N
Y
E
V
V
T
M
V
T
Site 70
Y585
V
T
R
G
H
R
L
Y
Q
P
K
L
A
S
N
Site 71
S591
L
Y
Q
P
K
L
A
S
N
Y
V
Y
E
V
M
Site 72
Y593
Q
P
K
L
A
S
N
Y
V
Y
E
V
M
L
R
Site 73
S611
E
K
P
E
G
R
P
S
F
E
D
L
L
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation