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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Casp2
Full Name:
Caspase-2
Alias:
CASP-2; Caspase 2, apoptosis-related cysteine peptidase; ICH- 1L/1S; ICH1; ICH-1 protease; NEDD2
Type:
Protease; EC 3.4.22.-; EC 3.4.22.55; Apoptosis
Mass (Da):
50685
Number AA:
452
UniProt ID:
P42575
International Prot ID:
IPI00291570
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0019899
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0051605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
P
S
A
G
S
W
S
T
F
Q
H
K
Site 2
T11
P
S
A
G
S
W
S
T
F
Q
H
K
E
L
M
Site 3
S82
Q
A
K
V
G
S
F
S
Q
N
V
E
L
L
N
Site 4
T109
F
C
E
A
L
R
E
T
K
Q
G
H
L
E
D
Site 5
S133
Q
H
V
L
P
P
L
S
C
D
Y
D
L
S
L
Site 6
S139
L
S
C
D
Y
D
L
S
L
P
F
P
V
C
E
Site 7
Y151
V
C
E
S
C
P
L
Y
K
K
L
R
L
S
T
Site 8
S157
L
Y
K
K
L
R
L
S
T
D
T
V
E
H
S
Site 9
T158
Y
K
K
L
R
L
S
T
D
T
V
E
H
S
L
Site 10
T160
K
L
R
L
S
T
D
T
V
E
H
S
L
D
N
Site 11
S164
S
T
D
T
V
E
H
S
L
D
N
K
D
G
P
Site 12
T180
C
L
Q
V
K
P
C
T
P
E
F
Y
Q
T
H
Site 13
Y184
K
P
C
T
P
E
F
Y
Q
T
H
F
Q
L
A
Site 14
S196
Q
L
A
Y
R
L
Q
S
R
P
R
G
L
A
L
Site 15
S220
E
K
E
L
E
F
R
S
G
G
D
V
D
H
S
Site 16
S227
S
G
G
D
V
D
H
S
T
L
V
T
L
F
K
Site 17
T325
Q
A
C
R
G
D
E
T
D
R
G
V
D
Q
Q
Site 18
S340
D
G
K
N
H
A
G
S
P
G
C
E
E
S
D
Site 19
S346
G
S
P
G
C
E
E
S
D
A
G
K
E
K
L
Site 20
T360
L
P
K
M
R
L
P
T
R
S
D
M
I
C
G
Site 21
Y368
R
S
D
M
I
C
G
Y
A
C
L
K
G
T
A
Site 22
T374
G
Y
A
C
L
K
G
T
A
A
M
R
N
T
K
Site 23
S384
M
R
N
T
K
R
G
S
W
Y
I
E
A
L
A
Site 24
S395
E
A
L
A
Q
V
F
S
E
R
A
C
D
M
H
Site 25
Y420
L
I
K
D
R
E
G
Y
A
P
G
T
E
F
H
Site 26
Y435
R
C
K
E
M
S
E
Y
C
S
T
L
C
R
H
Site 27
Y444
S
T
L
C
R
H
L
Y
L
F
P
G
H
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation