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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
mGluR5
Full Name:
Metabotropic glutamate receptor 5
Alias:
Glutamate receptor, metabotropic 5; GPRC1E; GRM5; MGlu5; MGLUR5; MGR5
Type:
G protein-coupled 7TM receptor, glutamate
Mass (Da):
132469
Number AA:
1212
UniProt ID:
P41594
International Prot ID:
IPI00296244
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0008066
PhosphoSite+
KinaseNET
Biological Process:
GO:0007206
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Metabotropic glutamate receptor 5 pan-specific antibody AB-NN291-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN291-1#Metabotropic glutamate receptor 5 pan-specific antibody AB-NN291-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN291-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
L
K
E
D
V
R
G
S
A
Q
S
S
E
R
R
Site 2
S22
D
V
R
G
S
A
Q
S
S
E
R
R
V
V
A
Site 3
S23
V
R
G
S
A
Q
S
S
E
R
R
V
V
A
H
Site 4
Y64
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
Site 5
T75
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
Site 6
S81
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
Site 7
T84
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
Site 8
S102
I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
Site 9
S109
S
A
V
A
L
E
Q
S
I
E
F
I
R
D
S
Site 10
S116
S
I
E
F
I
R
D
S
L
I
S
S
E
E
E
Site 11
S119
F
I
R
D
S
L
I
S
S
E
E
E
E
G
L
Site 12
S120
I
R
D
S
L
I
S
S
E
E
E
E
G
L
V
Site 13
S133
L
V
R
C
V
D
G
S
S
S
S
F
R
S
K
Site 14
S134
V
R
C
V
D
G
S
S
S
S
F
R
S
K
K
Site 15
S135
R
C
V
D
G
S
S
S
S
F
R
S
K
K
P
Site 16
S136
C
V
D
G
S
S
S
S
F
R
S
K
K
P
I
Site 17
S139
G
S
S
S
S
F
R
S
K
K
P
I
V
G
V
Site 18
S173
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
Site 19
S180
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
Site 20
T183
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
Site 21
Y187
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
Site 22
Y213
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
Site 23
T219
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
Site 24
Y223
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
Site 25
Y249
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
Site 26
S250
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
F
Site 27
S256
Y
S
N
A
G
E
Q
S
F
D
K
L
L
K
K
Site 28
S266
K
L
L
K
K
L
T
S
H
L
P
K
A
R
V
Site 29
T282
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
Site 30
S304
G
E
F
L
L
L
G
S
D
G
W
A
D
R
Y
Site 31
Y311
S
D
G
W
A
D
R
Y
D
V
T
D
G
Y
Q
Site 32
Y317
R
Y
D
V
T
D
G
Y
Q
R
E
A
V
G
G
Site 33
S331
G
I
T
I
K
L
Q
S
P
D
V
K
W
F
D
Site 34
Y340
D
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
Site 35
Y341
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
T
Site 36
T348
Y
L
K
L
R
P
E
T
N
H
R
N
P
W
F
Site 37
Y377
F
P
Q
E
N
S
K
Y
N
K
T
C
N
S
S
Site 38
T380
E
N
S
K
Y
N
K
T
C
N
S
S
L
T
L
Site 39
T389
N
S
S
L
T
L
K
T
H
H
V
Q
D
S
K
Site 40
S440
D
G
R
K
L
L
E
S
L
M
K
T
N
F
T
Site 41
S462
L
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
Site 42
Y466
N
G
D
S
P
G
R
Y
E
I
M
N
F
K
E
Site 43
Y478
F
K
E
M
G
K
D
Y
F
D
Y
I
N
V
G
Site 44
Y481
M
G
K
D
Y
F
D
Y
I
N
V
G
S
W
D
Site 45
S509
K
K
S
N
I
I
R
S
V
C
S
E
P
C
E
Site 46
Y542
T
P
C
K
E
N
E
Y
V
F
D
E
Y
T
C
Site 47
Y547
N
E
Y
V
F
D
E
Y
T
C
K
A
C
Q
L
Site 48
Y572
C
D
L
I
P
V
Q
Y
L
R
W
G
D
P
E
Site 49
S612
R
D
T
P
V
V
K
S
S
S
R
E
L
C
Y
Site 50
S613
D
T
P
V
V
K
S
S
S
R
E
L
C
Y
I
Site 51
Y643
I
A
K
P
K
Q
I
Y
C
Y
L
Q
R
I
G
Site 52
Y645
K
P
K
Q
I
Y
C
Y
L
Q
R
I
G
I
G
Site 53
S654
Q
R
I
G
I
G
L
S
P
A
M
S
Y
S
A
Site 54
T664
M
S
Y
S
A
L
V
T
K
T
N
R
I
A
R
Site 55
T682
G
S
K
K
K
I
C
T
K
K
P
R
F
M
S
Site 56
Y723
P
P
D
I
M
H
D
Y
P
S
I
R
E
V
Y
Site 57
Y730
Y
P
S
I
R
E
V
Y
L
I
C
N
T
T
N
Site 58
Y773
A
N
F
N
E
A
K
Y
I
A
F
T
M
Y
T
Site 59
T839
N
V
R
S
A
F
T
T
S
T
V
V
R
M
H
Site 60
S840
V
R
S
A
F
T
T
S
T
V
V
R
M
H
V
Site 61
T841
R
S
A
F
T
T
S
T
V
V
R
M
H
V
G
Site 62
S852
M
H
V
G
D
G
K
S
S
S
A
A
S
R
S
Site 63
S853
H
V
G
D
G
K
S
S
S
A
A
S
R
S
S
Site 64
S854
V
G
D
G
K
S
S
S
A
A
S
R
S
S
S
Site 65
S857
G
K
S
S
S
A
A
S
R
S
S
S
L
V
N
Site 66
S859
S
S
S
A
A
S
R
S
S
S
L
V
N
L
W
Site 67
S860
S
S
A
A
S
R
S
S
S
L
V
N
L
W
K
Site 68
S861
S
A
A
S
R
S
S
S
L
V
N
L
W
K
R
Site 69
S871
N
L
W
K
R
R
G
S
S
G
E
T
L
R
Y
Site 70
S872
L
W
K
R
R
G
S
S
G
E
T
L
R
Y
K
Site 71
T875
R
R
G
S
S
G
E
T
L
R
Y
K
D
R
R
Site 72
Y878
S
S
G
E
T
L
R
Y
K
D
R
R
L
A
Q
Site 73
S888
R
R
L
A
Q
H
K
S
E
I
E
C
F
T
P
Site 74
T894
K
S
E
I
E
C
F
T
P
K
G
S
M
G
N
Site 75
S898
E
C
F
T
P
K
G
S
M
G
N
G
G
R
A
Site 76
T906
M
G
N
G
G
R
A
T
M
S
S
S
N
G
K
Site 77
S908
N
G
G
R
A
T
M
S
S
S
N
G
K
S
V
Site 78
S909
G
G
R
A
T
M
S
S
S
N
G
K
S
V
T
Site 79
S910
G
R
A
T
M
S
S
S
N
G
K
S
V
T
W
Site 80
S914
M
S
S
S
N
G
K
S
V
T
W
A
Q
N
E
Site 81
S934
Q
H
L
W
Q
R
L
S
I
H
I
N
K
K
E
Site 82
S955
V
I
K
P
F
P
K
S
T
E
S
R
G
L
G
Site 83
T956
I
K
P
F
P
K
S
T
E
S
R
G
L
G
A
Site 84
S992
A
G
P
G
G
P
E
S
P
D
A
G
P
K
A
Site 85
Y1001
D
A
G
P
K
A
L
Y
D
V
A
E
A
E
E
Site 86
S1018
P
A
P
A
R
P
R
S
P
S
P
I
S
T
L
Site 87
S1020
P
A
R
P
R
S
P
S
P
I
S
T
L
S
H
Site 88
S1023
P
R
S
P
S
P
I
S
T
L
S
H
R
A
G
Site 89
T1024
R
S
P
S
P
I
S
T
L
S
H
R
A
G
S
Site 90
S1026
P
S
P
I
S
T
L
S
H
R
A
G
S
A
S
Site 91
S1031
T
L
S
H
R
A
G
S
A
S
R
T
D
D
D
Site 92
S1033
S
H
R
A
G
S
A
S
R
T
D
D
D
V
P
Site 93
T1035
R
A
G
S
A
S
R
T
D
D
D
V
P
S
L
Site 94
S1041
R
T
D
D
D
V
P
S
L
H
S
E
P
V
A
Site 95
S1044
D
D
V
P
S
L
H
S
E
P
V
A
R
S
S
Site 96
S1050
H
S
E
P
V
A
R
S
S
S
S
Q
G
S
L
Site 97
S1051
S
E
P
V
A
R
S
S
S
S
Q
G
S
L
M
Site 98
S1052
E
P
V
A
R
S
S
S
S
Q
G
S
L
M
E
Site 99
S1053
P
V
A
R
S
S
S
S
Q
G
S
L
M
E
Q
Site 100
S1056
R
S
S
S
S
Q
G
S
L
M
E
Q
I
S
S
Site 101
T1069
S
S
V
V
T
R
F
T
A
N
I
S
E
L
N
Site 102
S1081
E
L
N
S
M
M
L
S
T
A
A
P
S
P
G
Site 103
S1143
A
G
D
A
A
R
E
S
P
A
A
G
P
E
A
Site 104
T1164
L
E
E
L
V
A
L
T
P
P
S
P
F
R
D
Site 105
S1167
L
V
A
L
T
P
P
S
P
F
R
D
S
V
D
Site 106
S1172
P
P
S
P
F
R
D
S
V
D
S
G
S
T
T
Site 107
S1175
P
F
R
D
S
V
D
S
G
S
T
T
P
N
S
Site 108
S1177
R
D
S
V
D
S
G
S
T
T
P
N
S
P
V
Site 109
T1178
D
S
V
D
S
G
S
T
T
P
N
S
P
V
S
Site 110
T1179
S
V
D
S
G
S
T
T
P
N
S
P
V
S
E
Site 111
S1182
S
G
S
T
T
P
N
S
P
V
S
E
S
A
L
Site 112
S1185
T
T
P
N
S
P
V
S
E
S
A
L
C
I
P
Site 113
S1187
P
N
S
P
V
S
E
S
A
L
C
I
P
S
S
Site 114
S1193
E
S
A
L
C
I
P
S
S
P
K
Y
D
T
L
Site 115
S1194
S
A
L
C
I
P
S
S
P
K
Y
D
T
L
I
Site 116
Y1197
C
I
P
S
S
P
K
Y
D
T
L
I
I
R
D
Site 117
T1199
P
S
S
P
K
Y
D
T
L
I
I
R
D
Y
T
Site 118
Y1205
D
T
L
I
I
R
D
Y
T
Q
S
S
S
S
L
Site 119
T1206
T
L
I
I
R
D
Y
T
Q
S
S
S
S
L
_
Site 120
S1208
I
I
R
D
Y
T
Q
S
S
S
S
L
_
_
_
Site 121
S1211
D
Y
T
Q
S
S
S
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation