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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Bcl-6
Full Name:
B-cell lymphoma 6 protein
Alias:
B-cell CLL/lymphoma 6; B-cell lymphoma 6 protein homolog; Bcl5; Bcl-5; Bcl6; BCL6A; LAZ3; LAZ-3 protein; ZBTB27; Zinc finger protein 51; ZNF51
Type:
Transcription factor
Mass (Da):
78846
Number AA:
706
UniProt ID:
P41182
International Prot ID:
IPI00012820
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0002903
GO:0045749
GO:0030308
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
L
N
L
N
R
L
R
S
R
D
I
L
T
D
V
Site 2
T48
E
Q
F
R
A
H
K
T
V
L
M
A
C
S
G
Site 3
S70
D
Q
L
K
C
N
L
S
V
I
N
L
D
P
E
Site 4
S134
A
S
E
A
E
M
V
S
A
I
K
P
P
R
E
Site 5
S146
P
R
E
E
F
L
N
S
R
M
L
M
P
Q
D
Site 6
Y157
M
P
Q
D
I
M
A
Y
R
G
R
E
V
V
E
Site 7
S171
E
N
N
L
P
L
R
S
A
P
G
C
E
S
R
Site 8
S177
R
S
A
P
G
C
E
S
R
A
F
A
P
S
L
Site 9
S183
E
S
R
A
F
A
P
S
L
Y
S
G
L
S
T
Site 10
S189
P
S
L
Y
S
G
L
S
T
P
P
A
S
Y
S
Site 11
T190
S
L
Y
S
G
L
S
T
P
P
A
S
Y
S
M
Site 12
S194
G
L
S
T
P
P
A
S
Y
S
M
Y
S
H
L
Site 13
S196
S
T
P
P
A
S
Y
S
M
Y
S
H
L
P
V
Site 14
S199
P
A
S
Y
S
M
Y
S
H
L
P
V
S
S
L
Site 15
S205
Y
S
H
L
P
V
S
S
L
L
F
S
D
E
E
Site 16
S209
P
V
S
S
L
L
F
S
D
E
E
F
R
D
V
Site 17
S234
E
R
A
L
P
C
D
S
A
R
P
V
P
G
E
Site 18
Y242
A
R
P
V
P
G
E
Y
S
R
P
T
L
E
V
Site 19
T246
P
G
E
Y
S
R
P
T
L
E
V
S
P
N
V
Site 20
S250
S
R
P
T
L
E
V
S
P
N
V
C
H
S
N
Site 21
S256
V
S
P
N
V
C
H
S
N
I
Y
S
P
K
E
Site 22
S260
V
C
H
S
N
I
Y
S
P
K
E
T
I
P
E
Site 23
T264
N
I
Y
S
P
K
E
T
I
P
E
E
A
R
S
Site 24
S271
T
I
P
E
E
A
R
S
D
M
H
Y
S
V
A
Site 25
Y275
E
A
R
S
D
M
H
Y
S
V
A
E
G
L
K
Site 26
S276
A
R
S
D
M
H
Y
S
V
A
E
G
L
K
P
Site 27
S287
G
L
K
P
A
A
P
S
A
R
N
A
P
Y
F
Site 28
Y293
P
S
A
R
N
A
P
Y
F
P
C
D
K
A
S
Site 29
S300
Y
F
P
C
D
K
A
S
K
E
E
E
R
P
S
Site 30
S307
S
K
E
E
E
R
P
S
S
E
D
E
I
A
L
Site 31
S308
K
E
E
E
R
P
S
S
E
D
E
I
A
L
H
Site 32
S330
L
N
R
K
G
L
V
S
P
Q
S
P
Q
K
S
Site 33
S333
K
G
L
V
S
P
Q
S
P
Q
K
S
D
C
Q
Site 34
S337
S
P
Q
S
P
Q
K
S
D
C
Q
P
N
S
P
Site 35
S343
K
S
D
C
Q
P
N
S
P
T
E
S
C
S
S
Site 36
T345
D
C
Q
P
N
S
P
T
E
S
C
S
S
K
N
Site 37
S347
Q
P
N
S
P
T
E
S
C
S
S
K
N
A
C
Site 38
S350
S
P
T
E
S
C
S
S
K
N
A
C
I
L
Q
Site 39
S359
N
A
C
I
L
Q
A
S
G
S
P
P
A
K
S
Site 40
S361
C
I
L
Q
A
S
G
S
P
P
A
K
S
P
T
Site 41
S366
S
G
S
P
P
A
K
S
P
T
D
P
K
A
C
Site 42
T368
S
P
P
A
K
S
P
T
D
P
K
A
C
N
W
Site 43
Y378
K
A
C
N
W
K
K
Y
K
F
I
V
L
N
S
Site 44
S404
Q
A
E
L
G
R
L
S
P
R
A
Y
T
A
P
Site 45
Y408
G
R
L
S
P
R
A
Y
T
A
P
P
A
C
Q
Site 46
T409
R
L
S
P
R
A
Y
T
A
P
P
A
C
Q
P
Site 47
S427
P
E
N
L
D
L
Q
S
P
T
K
L
S
A
S
Site 48
S432
L
Q
S
P
T
K
L
S
A
S
G
E
D
S
T
Site 49
S434
S
P
T
K
L
S
A
S
G
E
D
S
T
I
P
Site 50
S438
L
S
A
S
G
E
D
S
T
I
P
Q
A
S
R
Site 51
T439
S
A
S
G
E
D
S
T
I
P
Q
A
S
R
L
Site 52
S453
L
N
N
I
V
N
R
S
M
T
G
S
P
R
S
Site 53
T455
N
I
V
N
R
S
M
T
G
S
P
R
S
S
S
Site 54
S457
V
N
R
S
M
T
G
S
P
R
S
S
S
E
S
Site 55
S460
S
M
T
G
S
P
R
S
S
S
E
S
H
S
P
Site 56
S461
M
T
G
S
P
R
S
S
S
E
S
H
S
P
L
Site 57
S462
T
G
S
P
R
S
S
S
E
S
H
S
P
L
Y
Site 58
S464
S
P
R
S
S
S
E
S
H
S
P
L
Y
M
H
Site 59
S466
R
S
S
S
E
S
H
S
P
L
Y
M
H
P
P
Site 60
Y469
S
E
S
H
S
P
L
Y
M
H
P
P
K
C
T
Site 61
T476
Y
M
H
P
P
K
C
T
S
C
G
S
Q
S
P
Site 62
S477
M
H
P
P
K
C
T
S
C
G
S
Q
S
P
Q
Site 63
S480
P
K
C
T
S
C
G
S
Q
S
P
Q
H
A
E
Site 64
T504
F
P
E
E
M
G
E
T
Q
S
E
Y
S
D
S
Site 65
S506
E
E
M
G
E
T
Q
S
E
Y
S
D
S
S
C
Site 66
Y508
M
G
E
T
Q
S
E
Y
S
D
S
S
C
E
N
Site 67
S509
G
E
T
Q
S
E
Y
S
D
S
S
C
E
N
G
Site 68
S511
T
Q
S
E
Y
S
D
S
S
C
E
N
G
A
F
Site 69
S512
Q
S
E
Y
S
D
S
S
C
E
N
G
A
F
F
Site 70
S528
N
E
C
D
C
R
F
S
E
E
A
S
L
K
R
Site 71
S532
C
R
F
S
E
E
A
S
L
K
R
H
T
L
Q
Site 72
T537
E
A
S
L
K
R
H
T
L
Q
T
H
S
D
K
Site 73
T540
L
K
R
H
T
L
Q
T
H
S
D
K
P
Y
K
Site 74
Y546
Q
T
H
S
D
K
P
Y
K
C
D
R
C
Q
A
Site 75
S563
R
Y
K
G
N
L
A
S
H
K
T
V
H
T
G
Site 76
T566
G
N
L
A
S
H
K
T
V
H
T
G
E
K
P
Site 77
T569
A
S
H
K
T
V
H
T
G
E
K
P
Y
R
C
Site 78
Y574
V
H
T
G
E
K
P
Y
R
C
N
I
C
G
A
Site 79
T591
N
R
P
A
N
L
K
T
H
T
R
I
H
S
G
Site 80
T593
P
A
N
L
K
T
H
T
R
I
H
S
G
E
K
Site 81
S597
K
T
H
T
R
I
H
S
G
E
K
P
Y
K
C
Site 82
T625
R
A
H
V
L
I
H
T
G
E
K
P
Y
P
C
Site 83
Y630
I
H
T
G
E
K
P
Y
P
C
E
I
C
G
T
Site 84
T644
T
R
F
R
H
L
Q
T
L
K
S
H
L
R
I
Site 85
S647
R
H
L
Q
T
L
K
S
H
L
R
I
H
T
G
Site 86
T653
K
S
H
L
R
I
H
T
G
E
K
P
Y
H
C
Site 87
S671
N
L
H
F
R
H
K
S
Q
L
R
L
H
L
R
Site 88
S694
T
K
V
Q
Y
R
V
S
A
T
D
L
P
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation