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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAT3
Full Name:
Signal transducer and activator of transcription 3
Alias:
Acute-phase response factor; APRF
Type:
Nuclear receptor co-regulator; Transcription factor
Mass (Da):
88068
Number AA:
770
UniProt ID:
P40763
International Prot ID:
IPI00784414
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005062
GO:0046983
PhosphoSite+
KinaseNET
Biological Process:
GO:0060397
GO:0006928
GO:0042755
Phosida
TranscriptoNet
STRING
Kinexus Products
Signal transducer and activator of transcription 3 Y705+T708 phosphosite-specific antibody AB-PN539#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN539#Signal transducer and activator of transcription 3 (A702-T708, human) pY705+pT708 phosphopeptide - Powder PE-04ADO95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADO95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
L
Q
Q
L
D
T
R
Y
L
E
Q
L
H
Q
L
Site 2
Y22
L
E
Q
L
H
Q
L
Y
S
D
S
F
P
M
E
Site 3
S23
E
Q
L
H
Q
L
Y
S
D
S
F
P
M
E
L
Site 4
S25
L
H
Q
L
Y
S
D
S
F
P
M
E
L
R
Q
Site 5
Y45
I
E
S
Q
D
W
A
Y
A
A
S
K
E
S
H
Site 6
Y68
L
G
E
I
D
Q
Q
Y
S
R
F
L
Q
E
S
Site 7
Y79
L
Q
E
S
N
V
L
Y
Q
H
N
L
R
R
I
Site 8
T133
G
G
Q
A
N
H
P
T
A
A
V
V
T
E
K
Site 9
Y176
Q
D
D
F
D
F
N
Y
K
T
L
K
S
Q
G
Site 10
S181
F
N
Y
K
T
L
K
S
Q
G
D
M
Q
D
L
Site 11
S194
D
L
N
G
N
N
Q
S
V
T
R
Q
K
M
Q
Site 12
T208
Q
Q
L
E
Q
M
L
T
A
L
D
Q
M
R
R
Site 13
S216
A
L
D
Q
M
R
R
S
I
V
S
E
L
A
G
Site 14
Y230
G
L
L
S
A
M
E
Y
V
Q
K
T
L
T
D
Site 15
T234
A
M
E
Y
V
Q
K
T
L
T
D
E
E
L
A
Site 16
T268
D
R
L
E
N
W
I
T
S
L
A
E
S
Q
L
Site 17
S269
R
L
E
N
W
I
T
S
L
A
E
S
Q
L
Q
Site 18
S273
W
I
T
S
L
A
E
S
Q
L
Q
T
R
Q
Q
Site 19
S292
E
E
L
Q
Q
K
V
S
Y
K
G
D
P
I
V
Site 20
S319
L
F
R
N
L
M
K
S
A
F
V
V
E
R
Q
Site 21
S372
K
V
C
I
D
K
D
S
G
D
V
A
A
L
R
Site 22
S381
D
V
A
A
L
R
G
S
R
K
F
N
I
L
G
Site 23
S399
K
V
M
N
M
E
E
S
N
N
G
S
L
S
A
Site 24
S403
M
E
E
S
N
N
G
S
L
S
A
E
F
K
H
Site 25
S405
E
S
N
N
G
S
L
S
A
E
F
K
H
L
T
Site 26
T412
S
A
E
F
K
H
L
T
L
R
E
Q
R
C
G
Site 27
S429
G
R
A
N
C
D
A
S
L
I
V
T
E
E
L
Site 28
T440
T
E
E
L
H
L
I
T
F
E
T
E
V
Y
H
Site 29
Y446
I
T
F
E
T
E
V
Y
H
Q
G
L
K
I
D
Site 30
S509
D
Q
V
A
E
V
L
S
W
Q
F
S
S
T
T
Site 31
S513
E
V
L
S
W
Q
F
S
S
T
T
K
R
G
L
Site 32
S514
V
L
S
W
Q
F
S
S
T
T
K
R
G
L
S
Site 33
T515
L
S
W
Q
F
S
S
T
T
K
R
G
L
S
I
Site 34
T516
S
W
Q
F
S
S
T
T
K
R
G
L
S
I
E
Site 35
S521
S
T
T
K
R
G
L
S
I
E
Q
L
T
T
L
Site 36
Y539
L
L
G
P
G
V
N
Y
S
G
C
Q
I
T
W
Site 37
S540
L
G
P
G
V
N
Y
S
G
C
Q
I
T
W
A
Site 38
S590
G
Y
I
M
G
F
I
S
K
E
R
E
R
A
I
Site 39
S599
E
R
E
R
A
I
L
S
T
K
P
P
G
T
F
Site 40
T600
R
E
R
A
I
L
S
T
K
P
P
G
T
F
L
Site 41
T605
L
S
T
K
P
P
G
T
F
L
L
R
F
S
E
Site 42
S611
G
T
F
L
L
R
F
S
E
S
S
K
E
G
G
Site 43
S613
F
L
L
R
F
S
E
S
S
K
E
G
G
V
T
Site 44
S614
L
L
R
F
S
E
S
S
K
E
G
G
V
T
F
Site 45
T620
S
S
K
E
G
G
V
T
F
T
W
V
E
K
D
Site 46
S629
T
W
V
E
K
D
I
S
G
K
T
Q
I
Q
S
Site 47
T632
E
K
D
I
S
G
K
T
Q
I
Q
S
V
E
P
Site 48
S636
S
G
K
T
Q
I
Q
S
V
E
P
Y
T
K
Q
Site 49
Y640
Q
I
Q
S
V
E
P
Y
T
K
Q
Q
L
N
N
Site 50
S668
D
A
T
N
I
L
V
S
P
L
V
Y
L
Y
P
Site 51
Y674
V
S
P
L
V
Y
L
Y
P
D
I
P
K
E
E
Site 52
Y686
K
E
E
A
F
G
K
Y
C
R
P
E
S
Q
E
Site 53
S691
G
K
Y
C
R
P
E
S
Q
E
H
P
E
A
D
Site 54
S701
H
P
E
A
D
P
G
S
A
A
P
Y
L
K
T
Site 55
Y705
D
P
G
S
A
A
P
Y
L
K
T
K
F
I
C
Signal transducer and activator of transcription 3 Y705+T708 phosphosite-specific antibody AB-PN539#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN539#Signal transducer and activator of transcription 3 (A702-T708, human) pY705+pT708 phosphopeptide - Powder PE-04ADO95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADO95
Site 56
T708
S
A
A
P
Y
L
K
T
K
F
I
C
V
T
P
Signal transducer and activator of transcription 3 Y705+T708 phosphosite-specific antibody AB-PN539#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN539#Signal transducer and activator of transcription 3 (A702-T708, human) pY705+pT708 phosphopeptide - Powder PE-04ADO95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADO95
Site 57
T714
K
T
K
F
I
C
V
T
P
T
T
C
S
N
T
Site 58
T717
F
I
C
V
T
P
T
T
C
S
N
T
I
D
L
Site 59
S719
C
V
T
P
T
T
C
S
N
T
I
D
L
P
M
Site 60
T721
T
P
T
T
C
S
N
T
I
D
L
P
M
S
P
Site 61
S727
N
T
I
D
L
P
M
S
P
R
T
L
D
S
L
Site 62
T730
D
L
P
M
S
P
R
T
L
D
S
L
M
Q
F
Site 63
S733
M
S
P
R
T
L
D
S
L
M
Q
F
G
N
N
Site 64
S747
N
G
E
G
A
E
P
S
A
G
G
Q
F
E
S
Site 65
S754
S
A
G
G
Q
F
E
S
L
T
F
D
M
E
L
Site 66
T756
G
G
Q
F
E
S
L
T
F
D
M
E
L
T
S
Site 67
S763
T
F
D
M
E
L
T
S
E
C
A
T
S
P
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation