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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CUTL1
Full Name:
Homeobox protein cut-like 1
Alias:
CASP; CCAAT displacement protein; CDP; CDP/Cut; CDP/Cux; CDP1; Clox; CUT; Cut-like 1; Cut-like homeobox 1; CUX; Cux/CDP; Golgi integral membrane protein 6; GOLIM6
Type:
Transcription protein
Mass (Da):
164273
Number AA:
1505
UniProt ID:
P39880
International Prot ID:
IPI00026673
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0000122
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
L
K
R
E
L
D
A
T
A
T
V
L
A
N
R
Site 2
T18
R
E
L
D
A
T
A
T
V
L
A
N
R
Q
D
Site 3
S30
R
Q
D
E
S
E
Q
S
R
K
R
L
I
E
Q
Site 4
S38
R
K
R
L
I
E
Q
S
R
E
F
K
K
N
T
Site 5
T45
S
R
E
F
K
K
N
T
P
E
D
L
R
K
Q
Site 6
S59
Q
V
A
P
L
L
K
S
F
Q
G
E
I
D
A
Site 7
S68
Q
G
E
I
D
A
L
S
K
R
S
K
E
A
E
Site 8
T113
Q
R
L
H
D
I
E
T
E
N
Q
K
L
R
E
Site 9
T121
E
N
Q
K
L
R
E
T
L
E
E
Y
N
K
E
Site 10
Y149
L
K
E
K
I
R
E
Y
E
Q
T
L
K
N
Q
Site 11
T152
K
I
R
E
Y
E
Q
T
L
K
N
Q
A
E
T
Site 12
T182
K
E
R
K
L
Q
E
T
Q
M
S
T
T
S
K
Site 13
S185
K
L
Q
E
T
Q
M
S
T
T
S
K
L
E
E
Site 14
T209
T
A
L
E
K
T
R
T
E
L
F
D
L
K
T
Site 15
T216
T
E
L
F
D
L
K
T
K
Y
D
E
E
T
T
Site 16
Y218
L
F
D
L
K
T
K
Y
D
E
E
T
T
A
K
Site 17
T234
D
E
I
E
M
I
M
T
D
L
E
R
A
N
Q
Site 18
T252
V
A
Q
R
E
A
E
T
L
R
E
Q
L
S
S
Site 19
S258
E
T
L
R
E
Q
L
S
S
A
N
H
S
L
Q
Site 20
S259
T
L
R
E
Q
L
S
S
A
N
H
S
L
Q
L
Site 21
S263
Q
L
S
S
A
N
H
S
L
Q
L
A
S
Q
I
Site 22
S312
D
V
Q
R
L
Q
A
S
L
T
K
L
R
E
N
Site 23
T314
Q
R
L
Q
A
S
L
T
K
L
R
E
N
S
A
Site 24
S320
L
T
K
L
R
E
N
S
A
S
Q
I
S
Q
L
Site 25
S322
K
L
R
E
N
S
A
S
Q
I
S
Q
L
E
Q
Site 26
S332
S
Q
L
E
Q
Q
L
S
A
K
N
S
T
L
K
Site 27
S336
Q
Q
L
S
A
K
N
S
T
L
K
Q
L
E
E
Site 28
Y351
K
L
K
G
Q
A
D
Y
E
E
V
K
K
E
L
Site 29
S363
K
E
L
N
I
L
K
S
M
E
F
A
P
S
E
Site 30
S369
K
S
M
E
F
A
P
S
E
G
A
G
T
Q
D
Site 31
T374
A
P
S
E
G
A
G
T
Q
D
A
A
K
P
L
Site 32
S391
L
L
L
E
K
N
R
S
L
Q
S
E
N
A
A
Site 33
S402
E
N
A
A
L
R
I
S
N
S
D
L
S
G
S
Site 34
S404
A
A
L
R
I
S
N
S
D
L
S
G
S
A
R
Site 35
S407
R
I
S
N
S
D
L
S
G
S
A
R
R
K
G
Site 36
S409
S
N
S
D
L
S
G
S
A
R
R
K
G
K
D
Site 37
S420
K
G
K
D
Q
P
E
S
R
R
P
G
S
L
P
Site 38
S425
P
E
S
R
R
P
G
S
L
P
A
P
P
P
S
Site 39
S432
S
L
P
A
P
P
P
S
Q
L
P
R
N
P
G
Site 40
S443
R
N
P
G
E
Q
A
S
N
T
N
G
T
H
Q
Site 41
T448
Q
A
S
N
T
N
G
T
H
Q
F
S
P
A
G
Site 42
S452
T
N
G
T
H
Q
F
S
P
A
G
L
S
Q
D
Site 43
S457
Q
F
S
P
A
G
L
S
Q
D
F
F
S
S
S
Site 44
S462
G
L
S
Q
D
F
F
S
S
S
L
A
S
P
S
Site 45
S464
S
Q
D
F
F
S
S
S
L
A
S
P
S
L
P
Site 46
S467
F
F
S
S
S
L
A
S
P
S
L
P
L
A
S
Site 47
S482
T
G
K
F
A
L
N
S
L
L
Q
R
Q
L
M
Site 48
S491
L
Q
R
Q
L
M
Q
S
F
Y
S
K
A
M
Q
Site 49
S504
M
Q
E
A
G
S
T
S
M
I
F
S
T
G
P
Site 50
S508
G
S
T
S
M
I
F
S
T
G
P
Y
S
T
N
Site 51
T509
S
T
S
M
I
F
S
T
G
P
Y
S
T
N
S
Site 52
Y512
M
I
F
S
T
G
P
Y
S
T
N
S
I
S
S
Site 53
S513
I
F
S
T
G
P
Y
S
T
N
S
I
S
S
Q
Site 54
T514
F
S
T
G
P
Y
S
T
N
S
I
S
S
Q
S
Site 55
S516
T
G
P
Y
S
T
N
S
I
S
S
Q
S
P
L
Site 56
S518
P
Y
S
T
N
S
I
S
S
Q
S
P
L
Q
Q
Site 57
S519
Y
S
T
N
S
I
S
S
Q
S
P
L
Q
Q
S
Site 58
S521
T
N
S
I
S
S
Q
S
P
L
Q
Q
S
P
D
Site 59
S526
S
Q
S
P
L
Q
Q
S
P
D
V
N
G
M
A
Site 60
S535
D
V
N
G
M
A
P
S
P
S
Q
S
E
S
A
Site 61
S537
N
G
M
A
P
S
P
S
Q
S
E
S
A
G
S
Site 62
S539
M
A
P
S
P
S
Q
S
E
S
A
G
S
V
S
Site 63
S541
P
S
P
S
Q
S
E
S
A
G
S
V
S
E
G
Site 64
S544
S
Q
S
E
S
A
G
S
V
S
E
G
E
E
M
Site 65
S546
S
E
S
A
G
S
V
S
E
G
E
E
M
D
T
Site 66
T553
S
E
G
E
E
M
D
T
A
E
I
A
R
Q
V
Site 67
Y577
G
Q
R
I
F
G
H
Y
V
L
G
L
S
Q
G
Site 68
S585
V
L
G
L
S
Q
G
S
V
S
E
I
L
A
R
Site 69
S587
G
L
S
Q
G
S
V
S
E
I
L
A
R
P
K
Site 70
T600
P
K
P
W
N
K
L
T
V
R
G
K
E
P
F
Site 71
S615
H
K
M
K
Q
F
L
S
D
E
Q
N
I
L
A
Site 72
S652
V
P
K
R
R
N
G
S
E
G
N
I
T
T
R
Site 73
T657
N
G
S
E
G
N
I
T
T
R
I
R
A
S
E
Site 74
S663
I
T
T
R
I
R
A
S
E
T
G
S
D
E
A
Site 75
T665
T
R
I
R
A
S
E
T
G
S
D
E
A
I
K
Site 76
S667
I
R
A
S
E
T
G
S
D
E
A
I
K
S
I
Site 77
S673
G
S
D
E
A
I
K
S
I
L
E
Q
A
K
R
Site 78
T687
R
E
L
Q
V
Q
K
T
A
E
P
A
Q
P
S
Site 79
S694
T
A
E
P
A
Q
P
S
S
A
S
G
S
G
N
Site 80
S695
A
E
P
A
Q
P
S
S
A
S
G
S
G
N
S
Site 81
S697
P
A
Q
P
S
S
A
S
G
S
G
N
S
D
D
Site 82
S699
Q
P
S
S
A
S
G
S
G
N
S
D
D
A
I
Site 83
S702
S
A
S
G
S
G
N
S
D
D
A
I
R
S
I
Site 84
S734
A
L
K
Q
A
P
L
S
Q
S
D
I
T
I
L
Site 85
T739
P
L
S
Q
S
D
I
T
I
L
T
P
K
L
L
Site 86
T742
Q
S
D
I
T
I
L
T
P
K
L
L
S
T
S
Site 87
S749
T
P
K
L
L
S
T
S
P
M
P
T
V
S
S
Site 88
T753
L
S
T
S
P
M
P
T
V
S
S
Y
P
P
L
Site 89
S763
S
Y
P
P
L
A
I
S
L
K
K
P
S
A
A
Site 90
S768
A
I
S
L
K
K
P
S
A
A
P
E
A
G
A
Site 91
S776
A
A
P
E
A
G
A
S
A
L
P
N
P
P
A
Site 92
S837
P
E
R
R
N
A
A
S
S
E
E
A
K
A
E
Site 93
S838
E
R
R
N
A
A
S
S
E
E
A
K
A
E
E
Site 94
S854
G
G
G
K
E
K
G
S
G
G
S
G
G
G
S
Site 95
S857
K
E
K
G
S
G
G
S
G
G
G
S
Q
P
R
Site 96
S861
S
G
G
S
G
G
G
S
Q
P
R
A
E
R
S
Site 97
S868
S
Q
P
R
A
E
R
S
Q
L
Q
G
P
S
S
Site 98
S874
R
S
Q
L
Q
G
P
S
S
S
E
Y
W
K
E
Site 99
S875
S
Q
L
Q
G
P
S
S
S
E
Y
W
K
E
W
Site 100
S876
Q
L
Q
G
P
S
S
S
E
Y
W
K
E
W
P
Site 101
Y878
Q
G
P
S
S
S
E
Y
W
K
E
W
P
S
A
Site 102
S884
E
Y
W
K
E
W
P
S
A
E
S
P
Y
S
Q
Site 103
S887
K
E
W
P
S
A
E
S
P
Y
S
Q
S
S
E
Site 104
Y889
W
P
S
A
E
S
P
Y
S
Q
S
S
E
L
S
Site 105
S890
P
S
A
E
S
P
Y
S
Q
S
S
E
L
S
L
Site 106
S892
A
E
S
P
Y
S
Q
S
S
E
L
S
L
T
G
Site 107
S893
E
S
P
Y
S
Q
S
S
E
L
S
L
T
G
A
Site 108
S896
Y
S
Q
S
S
E
L
S
L
T
G
A
S
R
S
Site 109
T898
Q
S
S
E
L
S
L
T
G
A
S
R
S
E
T
Site 110
S903
S
L
T
G
A
S
R
S
E
T
P
Q
N
S
P
Site 111
T905
T
G
A
S
R
S
E
T
P
Q
N
S
P
L
P
Site 112
S909
R
S
E
T
P
Q
N
S
P
L
P
S
S
P
I
Site 113
S913
P
Q
N
S
P
L
P
S
S
P
I
V
P
M
S
Site 114
S914
Q
N
S
P
L
P
S
S
P
I
V
P
M
S
K
Site 115
S920
S
S
P
I
V
P
M
S
K
P
T
K
P
S
V
Site 116
S926
M
S
K
P
T
K
P
S
V
P
P
L
T
P
E
Site 117
T931
K
P
S
V
P
P
L
T
P
E
Q
Y
E
V
Y
Site 118
Y935
P
P
L
T
P
E
Q
Y
E
V
Y
M
Y
Q
E
Site 119
Y940
E
Q
Y
E
V
Y
M
Y
Q
E
V
D
T
I
E
Site 120
S974
G
E
K
V
L
G
L
S
Q
G
S
V
S
D
M
Site 121
S977
V
L
G
L
S
Q
G
S
V
S
D
M
L
S
R
Site 122
S979
G
L
S
Q
G
S
V
S
D
M
L
S
R
P
K
Site 123
S983
G
S
V
S
D
M
L
S
R
P
K
P
W
S
K
Site 124
S989
L
S
R
P
K
P
W
S
K
L
T
Q
K
G
R
Site 125
S1028
Q
Q
G
P
V
L
H
S
V
T
S
L
Q
D
P
Site 126
S1031
P
V
L
H
S
V
T
S
L
Q
D
P
L
Q
Q
Site 127
S1043
L
Q
Q
G
C
V
S
S
E
S
T
P
K
T
S
Site 128
S1045
Q
G
C
V
S
S
E
S
T
P
K
T
S
A
S
Site 129
T1046
G
C
V
S
S
E
S
T
P
K
T
S
A
S
C
Site 130
T1049
S
S
E
S
T
P
K
T
S
A
S
C
S
P
A
Site 131
S1050
S
E
S
T
P
K
T
S
A
S
C
S
P
A
P
Site 132
S1052
S
T
P
K
T
S
A
S
C
S
P
A
P
E
S
Site 133
S1054
P
K
T
S
A
S
C
S
P
A
P
E
S
P
M
Site 134
S1059
S
C
S
P
A
P
E
S
P
M
S
S
S
E
S
Site 135
S1062
P
A
P
E
S
P
M
S
S
S
E
S
V
K
S
Site 136
S1063
A
P
E
S
P
M
S
S
S
E
S
V
K
S
L
Site 137
S1064
P
E
S
P
M
S
S
S
E
S
V
K
S
L
T
Site 138
S1066
S
P
M
S
S
S
E
S
V
K
S
L
T
E
L
Site 139
S1069
S
S
S
E
S
V
K
S
L
T
E
L
V
Q
Q
Site 140
T1071
S
E
S
V
K
S
L
T
E
L
V
Q
Q
P
C
Site 141
S1084
P
C
P
P
I
E
A
S
K
D
S
K
P
P
E
Site 142
S1087
P
I
E
A
S
K
D
S
K
P
P
E
P
S
D
Site 143
S1093
D
S
K
P
P
E
P
S
D
P
P
A
S
D
S
Site 144
S1098
E
P
S
D
P
P
A
S
D
S
Q
P
T
T
P
Site 145
S1100
S
D
P
P
A
S
D
S
Q
P
T
T
P
L
P
Site 146
T1103
P
A
S
D
S
Q
P
T
T
P
L
P
L
S
G
Site 147
T1104
A
S
D
S
Q
P
T
T
P
L
P
L
S
G
H
Site 148
S1123
I
Q
E
L
V
A
M
S
P
E
L
D
T
Y
G
Site 149
Y1129
M
S
P
E
L
D
T
Y
G
I
T
K
R
V
K
Site 150
T1140
K
R
V
K
E
V
L
T
D
N
N
L
G
Q
R
Site 151
T1157
G
E
T
I
L
G
L
T
Q
G
S
V
S
D
L
Site 152
S1160
I
L
G
L
T
Q
G
S
V
S
D
L
L
A
R
Site 153
S1162
G
L
T
Q
G
S
V
S
D
L
L
A
R
P
K
Site 154
S1175
P
K
P
W
H
K
L
S
L
K
G
R
E
P
F
Site 155
Y1209
K
R
M
E
K
K
A
Y
M
K
R
R
H
S
S
Site 156
S1215
A
Y
M
K
R
R
H
S
S
V
S
D
S
Q
P
Site 157
S1216
Y
M
K
R
R
H
S
S
V
S
D
S
Q
P
C
Site 158
S1218
K
R
R
H
S
S
V
S
D
S
Q
P
C
E
P
Site 159
S1220
R
H
S
S
V
S
D
S
Q
P
C
E
P
P
S
Site 160
S1227
S
Q
P
C
E
P
P
S
V
G
T
E
Y
S
Q
Site 161
T1230
C
E
P
P
S
V
G
T
E
Y
S
Q
G
A
S
Site 162
Y1232
P
P
S
V
G
T
E
Y
S
Q
G
A
S
P
Q
Site 163
S1233
P
S
V
G
T
E
Y
S
Q
G
A
S
P
Q
P
Site 164
S1237
T
E
Y
S
Q
G
A
S
P
Q
P
Q
H
Q
L
Site 165
Y1263
K
E
A
L
K
R
A
Y
Q
Q
K
P
Y
P
S
Site 166
Y1268
R
A
Y
Q
Q
K
P
Y
P
S
P
K
T
I
E
Site 167
S1270
Y
Q
Q
K
P
Y
P
S
P
K
T
I
E
D
L
Site 168
T1273
K
P
Y
P
S
P
K
T
I
E
D
L
A
T
Q
Site 169
T1279
K
T
I
E
D
L
A
T
Q
L
N
L
K
T
S
Site 170
Y1295
V
I
N
W
F
H
N
Y
R
S
R
I
R
R
E
Site 171
S1312
I
E
E
I
Q
A
G
S
Q
G
Q
A
G
A
S
Site 172
S1319
S
Q
G
Q
A
G
A
S
D
S
P
S
A
R
S
Site 173
S1321
G
Q
A
G
A
S
D
S
P
S
A
R
S
G
R
Site 174
S1323
A
G
A
S
D
S
P
S
A
R
S
G
R
A
A
Site 175
S1326
S
D
S
P
S
A
R
S
G
R
A
A
P
S
S
Site 176
S1332
R
S
G
R
A
A
P
S
S
E
G
D
S
C
D
Site 177
S1333
S
G
R
A
A
P
S
S
E
G
D
S
C
D
G
Site 178
S1337
A
P
S
S
E
G
D
S
C
D
G
V
E
A
T
Site 179
T1344
S
C
D
G
V
E
A
T
E
G
P
G
S
A
D
Site 180
S1349
E
A
T
E
G
P
G
S
A
D
T
E
E
P
K
Site 181
T1352
E
G
P
G
S
A
D
T
E
E
P
K
S
Q
G
Site 182
S1357
A
D
T
E
E
P
K
S
Q
G
E
A
E
R
E
Site 183
T1373
V
P
R
P
A
E
Q
T
E
P
P
P
S
G
T
Site 184
S1378
E
Q
T
E
P
P
P
S
G
T
P
G
P
D
D
Site 185
T1380
T
E
P
P
P
S
G
T
P
G
P
D
D
A
R
Site 186
S1404
E
G
P
G
P
L
P
S
P
A
S
A
T
A
T
Site 187
T1411
S
P
A
S
A
T
A
T
A
A
P
A
A
P
E
Site 188
S1436
G
E
G
P
A
A
P
S
S
A
P
P
P
S
N
Site 189
S1437
E
G
P
A
A
P
S
S
A
P
P
P
S
N
S
Site 190
S1442
P
S
S
A
P
P
P
S
N
S
S
S
S
S
A
Site 191
S1444
S
A
P
P
P
S
N
S
S
S
S
S
A
P
R
Site 192
S1445
A
P
P
P
S
N
S
S
S
S
S
A
P
R
R
Site 193
S1446
P
P
P
S
N
S
S
S
S
S
A
P
R
R
P
Site 194
S1447
P
P
S
N
S
S
S
S
S
A
P
R
R
P
S
Site 195
S1448
P
S
N
S
S
S
S
S
A
P
R
R
P
S
S
Site 196
S1454
S
S
A
P
R
R
P
S
S
L
Q
S
L
F
G
Site 197
S1455
S
A
P
R
R
P
S
S
L
Q
S
L
F
G
L
Site 198
S1458
R
R
P
S
S
L
Q
S
L
F
G
L
P
E
A
Site 199
S1471
E
A
A
G
A
R
D
S
R
D
N
P
L
R
K
Site 200
S1496
H
R
L
E
K
A
A
S
R
E
E
P
I
E
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation