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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FEN1
Full Name:
Flap endonuclease 1
Alias:
DNase IV; EC 3.1.-.-; FEN-1; Flap endonuclease-1; Flap structure-specific endonuclease 1; Maturation factor 1; Maturation factor-1; MF1; RAD2
Type:
Enzyme - Endonuclease
Mass (Da):
42593
Number AA:
380
UniProt ID:
P39748
International Prot ID:
IPI00026215
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008409
GO:0017108
GO:0003684
PhosphoSite+
KinaseNET
Biological Process:
GO:0043137
GO:0009650
GO:0006302
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
I
R
E
N
D
I
K
S
Y
F
G
R
K
V
A
Site 2
Y26
R
E
N
D
I
K
S
Y
F
G
R
K
V
A
I
Site 3
T60
L
Q
N
E
E
G
E
T
T
S
H
L
M
G
M
Site 4
T61
Q
N
E
E
G
E
T
T
S
H
L
M
G
M
F
Site 5
Y69
S
H
L
M
G
M
F
Y
R
T
I
R
M
M
E
Site 6
Y83
E
N
G
I
K
P
V
Y
V
F
D
G
K
P
P
Site 7
S94
G
K
P
P
Q
L
K
S
G
E
L
A
K
R
S
Site 8
S101
S
G
E
L
A
K
R
S
E
R
R
A
E
A
E
Site 9
S187
M
D
C
L
T
F
G
S
P
V
L
M
R
H
L
Site 10
T195
P
V
L
M
R
H
L
T
A
S
E
A
K
K
L
Site 11
S197
L
M
R
H
L
T
A
S
E
A
K
K
L
P
I
Site 12
S210
P
I
Q
E
F
H
L
S
R
I
L
Q
E
L
G
Site 13
Y234
C
I
L
L
G
S
D
Y
C
E
S
I
R
G
I
Site 14
S237
L
G
S
D
Y
C
E
S
I
R
G
I
G
P
K
Site 15
S255
D
L
I
Q
K
H
K
S
I
E
E
I
V
R
R
Site 16
Y268
R
R
L
D
P
N
K
Y
P
V
P
E
N
W
L
Site 17
S293
P
E
V
L
D
P
E
S
V
E
L
K
W
S
E
Site 18
S299
E
S
V
E
L
K
W
S
E
P
N
E
E
E
L
Site 19
S317
M
C
G
E
K
Q
F
S
E
E
R
I
R
S
G
Site 20
S323
F
S
E
E
R
I
R
S
G
V
K
R
L
S
K
Site 21
S329
R
S
G
V
K
R
L
S
K
S
R
Q
G
S
T
Site 22
S331
G
V
K
R
L
S
K
S
R
Q
G
S
T
Q
G
Site 23
S335
L
S
K
S
R
Q
G
S
T
Q
G
R
L
D
D
Site 24
T347
L
D
D
F
F
K
V
T
G
S
L
S
S
A
K
Site 25
S349
D
F
F
K
V
T
G
S
L
S
S
A
K
R
K
Site 26
S351
F
K
V
T
G
S
L
S
S
A
K
R
K
E
P
Site 27
S363
K
E
P
E
P
K
G
S
T
K
K
K
A
K
T
Site 28
T364
E
P
E
P
K
G
S
T
K
K
K
A
K
T
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation