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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPPM1A
Full Name:
Protein phosphatase 1A
Alias:
EC 3.1.3.16; IA; P2CA; PP2CA; PP2C-alpha; PPM1A
Type:
Protein-serine phosphatase
Mass (Da):
42448
Number AA:
382
UniProt ID:
P35813
International Prot ID:
IPI00020950
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008287
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0030145
GO:0004722
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0043123
GO:0030177
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
G
Q
G
N
G
L
R
Y
G
L
S
S
M
Q
G
Site 2
S27
N
G
L
R
Y
G
L
S
S
M
Q
G
W
R
V
Site 3
S28
G
L
R
Y
G
L
S
S
M
Q
G
W
R
V
E
Site 4
S54
P
S
G
L
E
S
W
S
F
F
A
V
Y
D
G
Site 5
Y59
S
W
S
F
F
A
V
Y
D
G
H
A
G
S
Q
Site 6
Y70
A
G
S
Q
V
A
K
Y
C
C
E
H
L
L
D
Site 7
T80
E
H
L
L
D
H
I
T
N
N
Q
D
F
K
G
Site 8
S93
K
G
S
A
G
A
P
S
V
E
N
V
K
N
G
Site 9
S116
D
E
H
M
R
V
M
S
E
K
K
H
G
A
D
Site 10
S125
K
K
H
G
A
D
R
S
G
S
T
A
V
G
V
Site 11
Y140
L
I
S
P
Q
H
T
Y
F
I
N
C
G
D
S
Site 12
T161
N
R
K
V
H
F
F
T
Q
D
H
K
P
S
N
Site 13
Y202
R
A
L
G
D
F
D
Y
K
C
V
H
G
K
G
Site 14
S216
G
P
T
E
Q
L
V
S
P
E
P
E
V
H
D
Site 15
T274
V
C
N
E
V
V
D
T
C
L
Y
K
G
S
R
Site 16
Y277
E
V
V
D
T
C
L
Y
K
G
S
R
D
N
M
Site 17
S285
K
G
S
R
D
N
M
S
V
I
L
I
C
F
P
Site 18
S298
F
P
N
A
P
K
V
S
P
E
A
V
K
K
E
Site 19
Y311
K
E
A
E
L
D
K
Y
L
E
C
R
V
E
E
Site 20
S344
L
A
S
E
N
I
P
S
L
P
P
G
G
E
L
Site 21
S353
P
P
G
G
E
L
A
S
K
R
N
V
I
E
A
Site 22
Y362
R
N
V
I
E
A
V
Y
N
R
L
N
P
Y
K
Site 23
T373
N
P
Y
K
N
D
D
T
D
S
T
S
T
D
D
Site 24
S375
Y
K
N
D
D
T
D
S
T
S
T
D
D
M
W
Site 25
S377
N
D
D
T
D
S
T
S
T
D
D
M
W
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation