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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH9
Full Name:
Myosin-9
Alias:
Cellular myosin heavy chain, type A; DFNA17; EPSTS; FTNS; MHA; Myosin, heavy chain 9, non-muscle; Myosin, heavy polypeptide 9, non-muscle; NMHC-II-A; NMMHCA; NMMHC-A; Nonmuscle myosin heavy chain II-A; Nonmuscle myosin heavy chain-A
Type:
Motor protein
Mass (Da):
226532
Number AA:
1960
UniProt ID:
P35579
International Prot ID:
IPI00019502
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005826
GO:0032154
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0043531
GO:0005524
GO:0051015
PhosphoSite+
KinaseNET
Biological Process:
GO:0031532
GO:0030048
GO:0001525
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
Q
Q
A
A
D
K
Y
L
Y
V
D
K
N
F
Site 2
Y11
Q
A
A
D
K
Y
L
Y
V
D
K
N
F
I
N
Site 3
S36
K
K
L
V
W
V
P
S
D
K
S
G
F
E
P
Site 4
S39
V
W
V
P
S
D
K
S
G
F
E
P
A
S
L
Site 5
S45
K
S
G
F
E
P
A
S
L
K
E
E
V
G
E
Site 6
Y105
L
H
N
L
K
E
R
Y
Y
S
G
L
I
Y
T
Site 7
Y106
H
N
L
K
E
R
Y
Y
S
G
L
I
Y
T
Y
Site 8
S107
N
L
K
E
R
Y
Y
S
G
L
I
Y
T
Y
S
Site 9
Y130
P
Y
K
N
L
P
I
Y
S
E
E
I
V
E
M
Site 10
Y138
S
E
E
I
V
E
M
Y
K
G
K
K
R
H
E
Site 11
Y151
H
E
M
P
P
H
I
Y
A
I
T
D
T
A
Y
Site 12
Y158
Y
A
I
T
D
T
A
Y
R
S
M
M
Q
D
R
Site 13
S169
M
Q
D
R
E
D
Q
S
I
L
C
T
G
E
S
Site 14
T173
E
D
Q
S
I
L
C
T
G
E
S
G
A
G
K
Site 15
S176
S
I
L
C
T
G
E
S
G
A
G
K
T
E
N
Site 16
T181
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Site 17
T184
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
Site 18
Y190
N
T
K
K
V
I
Q
Y
L
A
Y
V
A
S
S
Site 19
Y193
K
V
I
Q
Y
L
A
Y
V
A
S
S
H
K
S
Site 20
S196
Q
Y
L
A
Y
V
A
S
S
H
K
S
K
K
D
Site 21
S200
Y
V
A
S
S
H
K
S
K
K
D
Q
G
E
L
Site 22
T226
E
A
F
G
N
A
K
T
V
K
N
D
N
S
S
Site 23
S232
K
T
V
K
N
D
N
S
S
R
F
G
K
F
I
Site 24
S233
T
V
K
N
D
N
S
S
R
F
G
K
F
I
R
Site 25
Y257
V
G
A
N
I
E
T
Y
L
L
E
K
S
R
A
Site 26
S262
E
T
Y
L
L
E
K
S
R
A
I
R
Q
A
K
Site 27
T273
R
Q
A
K
E
E
R
T
F
H
I
F
Y
Y
L
Site 28
Y278
E
R
T
F
H
I
F
Y
Y
L
L
S
G
A
G
Site 29
T290
G
A
G
E
H
L
K
T
D
L
L
L
E
P
Y
Site 30
Y300
L
L
E
P
Y
N
K
Y
R
F
L
S
N
G
H
Site 31
S344
M
G
L
L
R
V
I
S
G
V
L
Q
L
G
N
Site 32
T360
V
F
K
K
E
R
N
T
D
Q
A
S
M
P
D
Site 33
S364
E
R
N
T
D
Q
A
S
M
P
D
N
T
A
A
Site 34
T383
H
L
L
G
I
N
V
T
D
F
T
R
G
I
L
Site 35
T386
G
I
N
V
T
D
F
T
R
G
I
L
T
P
R
Site 36
T391
D
F
T
R
G
I
L
T
P
R
I
K
V
G
R
Site 37
Y400
R
I
K
V
G
R
D
Y
V
Q
K
A
Q
T
K
Site 38
Y422
E
A
L
A
K
A
T
Y
E
R
M
F
R
W
L
Site 39
T440
I
N
K
A
L
D
K
T
K
R
Q
G
A
S
F
Site 40
S446
K
T
K
R
Q
G
A
S
F
I
G
I
L
D
I
Site 41
T472
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
L
Site 42
Y492
F
I
L
E
Q
E
E
Y
Q
R
E
G
I
E
W
Site 43
S541
F
P
K
A
T
D
K
S
F
V
E
K
V
M
Q
Site 44
Y579
H
Y
A
G
K
V
D
Y
K
A
D
E
W
L
M
Site 45
S604
A
T
L
L
H
Q
S
S
D
K
F
V
S
E
L
Site 46
T638
A
L
P
G
A
F
K
T
R
K
G
M
F
R
T
Site 47
T645
T
R
K
G
M
F
R
T
V
G
Q
L
Y
K
E
Site 48
T660
Q
L
A
K
L
M
A
T
L
R
N
T
N
P
N
Site 49
T664
L
M
A
T
L
R
N
T
N
P
N
F
V
R
C
Site 50
Y721
F
Q
E
F
R
Q
R
Y
E
I
L
T
P
N
S
Site 51
T725
R
Q
R
Y
E
I
L
T
P
N
S
I
P
K
G
Site 52
S728
Y
E
I
L
T
P
N
S
I
P
K
G
F
M
D
Site 53
Y754
L
E
L
D
S
N
L
Y
R
I
G
Q
S
K
V
Site 54
S759
N
L
Y
R
I
G
Q
S
K
V
F
F
R
A
G
Site 55
T780
E
E
R
D
L
K
I
T
D
V
I
I
G
F
Q
Site 56
T807
A
K
R
Q
Q
Q
L
T
A
M
K
V
L
Q
R
Site 57
Y819
L
Q
R
N
C
A
A
Y
L
K
L
R
N
W
Q
Site 58
T869
L
A
A
E
N
R
L
T
E
M
E
T
L
Q
S
Site 59
S876
T
E
M
E
T
L
Q
S
Q
L
M
A
E
K
L
Site 60
T907
E
E
L
R
A
R
L
T
A
K
K
Q
E
L
E
Site 61
S957
E
Q
L
E
E
E
E
S
A
R
Q
K
L
Q
L
Site 62
T969
L
Q
L
E
K
V
T
T
E
A
K
L
K
K
L
Site 63
T1005
E
D
R
I
A
E
F
T
T
N
L
T
E
E
E
Site 64
S1015
L
T
E
E
E
E
K
S
K
S
L
A
K
L
K
Site 65
S1017
E
E
E
E
K
S
K
S
L
A
K
L
K
N
K
Site 66
T1030
N
K
H
E
A
M
I
T
D
L
E
E
R
L
R
Site 67
T1049
Q
R
Q
E
L
E
K
T
R
R
K
L
E
G
D
Site 68
S1057
R
R
K
L
E
G
D
S
T
D
L
S
D
Q
I
Site 69
T1058
R
K
L
E
G
D
S
T
D
L
S
D
Q
I
A
Site 70
S1061
E
G
D
S
T
D
L
S
D
Q
I
A
E
L
Q
Site 71
S1111
K
K
I
R
E
L
E
S
Q
I
S
E
L
Q
E
Site 72
S1114
R
E
L
E
S
Q
I
S
E
L
Q
E
D
L
E
Site 73
S1122
E
L
Q
E
D
L
E
S
E
R
A
S
R
N
K
Site 74
S1126
D
L
E
S
E
R
A
S
R
N
K
A
E
K
Q
Site 75
T1146
E
E
L
E
A
L
K
T
E
L
E
D
T
L
D
Site 76
T1151
L
K
T
E
L
E
D
T
L
D
S
T
A
A
Q
Site 77
S1154
E
L
E
D
T
L
D
S
T
A
A
Q
Q
E
L
Site 78
T1155
L
E
D
T
L
D
S
T
A
A
Q
Q
E
L
R
Site 79
S1163
A
A
Q
Q
E
L
R
S
K
R
E
Q
E
V
N
Site 80
T1182
T
L
E
E
E
A
K
T
H
E
A
Q
I
Q
E
Site 81
S1195
Q
E
M
R
Q
K
H
S
Q
A
V
E
E
L
A
Site 82
S1243
L
L
Q
G
K
G
D
S
E
H
K
R
K
K
V
Site 83
T1269
N
E
G
E
R
V
R
T
E
L
A
D
K
V
T
Site 84
T1286
Q
V
E
L
D
N
V
T
G
L
L
S
Q
S
D
Site 85
S1290
D
N
V
T
G
L
L
S
Q
S
D
S
K
S
S
Site 86
S1292
V
T
G
L
L
S
Q
S
D
S
K
S
S
K
L
Site 87
S1294
G
L
L
S
Q
S
D
S
K
S
S
K
L
T
K
Site 88
S1296
L
S
Q
S
D
S
K
S
S
K
L
T
K
D
F
Site 89
T1300
D
S
K
S
S
K
L
T
K
D
F
S
A
L
E
Site 90
S1304
S
K
L
T
K
D
F
S
A
L
E
S
Q
L
Q
Site 91
S1308
K
D
F
S
A
L
E
S
Q
L
Q
D
T
Q
E
Site 92
S1326
E
E
N
R
Q
K
L
S
L
S
T
K
L
K
Q
Site 93
S1328
N
R
Q
K
L
S
L
S
T
K
L
K
Q
V
E
Site 94
T1329
R
Q
K
L
S
L
S
T
K
L
K
Q
V
E
D
Site 95
S1340
Q
V
E
D
E
K
N
S
F
R
E
Q
L
E
E
Site 96
S1376
M
K
K
K
M
E
D
S
V
G
C
L
E
T
A
Site 97
T1382
D
S
V
G
C
L
E
T
A
E
E
V
K
R
K
Site 98
S1398
Q
K
D
L
E
G
L
S
Q
R
H
E
E
K
V
Site 99
Y1408
H
E
E
K
V
A
A
Y
D
K
L
E
K
T
K
Site 100
T1414
A
Y
D
K
L
E
K
T
K
T
R
L
Q
Q
E
Site 101
T1416
D
K
L
E
K
T
K
T
R
L
Q
Q
E
L
D
Site 102
S1435
D
L
D
H
Q
R
Q
S
A
C
N
L
E
K
K
Site 103
S1457
L
A
E
E
K
T
I
S
A
K
Y
A
E
E
R
Site 104
Y1460
E
K
T
I
S
A
K
Y
A
E
E
R
D
R
A
Site 105
S1480
E
K
E
T
K
A
L
S
L
A
R
A
L
E
E
Site 106
S1511
T
E
M
E
D
L
M
S
S
K
D
D
V
G
K
Site 107
S1519
S
K
D
D
V
G
K
S
V
H
E
L
E
K
S
Site 108
S1526
S
V
H
E
L
E
K
S
K
R
A
L
E
Q
Q
Site 109
T1539
Q
Q
V
E
E
M
K
T
Q
L
E
E
L
E
D
Site 110
T1551
L
E
D
E
L
Q
A
T
E
D
A
K
L
R
L
Site 111
S1580
L
Q
G
R
D
E
Q
S
E
E
K
K
K
Q
L
Site 112
S1628
D
L
E
A
H
I
D
S
A
N
K
N
R
D
E
Site 113
T1657
C
M
R
E
L
D
D
T
R
A
S
R
E
E
I
Site 114
S1660
E
L
D
D
T
R
A
S
R
E
E
I
L
A
Q
Site 115
S1677
E
N
E
K
K
L
K
S
M
E
A
E
M
I
Q
Site 116
S1713
L
A
D
E
I
A
N
S
S
G
K
G
A
L
A
Site 117
S1714
A
D
E
I
A
N
S
S
G
K
G
A
L
A
L
Site 118
T1745
L
E
E
E
Q
G
N
T
E
L
I
N
D
R
L
Site 119
S1771
T
D
L
N
L
E
R
S
H
A
Q
K
N
E
N
Site 120
T1800
K
L
Q
E
M
E
G
T
V
K
S
K
Y
K
A
Site 121
S1803
E
M
E
G
T
V
K
S
K
Y
K
A
S
I
T
Site 122
Y1805
E
G
T
V
K
S
K
Y
K
A
S
I
T
A
L
Site 123
S1808
V
K
S
K
Y
K
A
S
I
T
A
L
E
A
K
Site 124
T1810
S
K
Y
K
A
S
I
T
A
L
E
A
K
I
A
Site 125
T1840
A
C
K
Q
V
R
R
T
E
K
K
L
K
D
V
Site 126
Y1861
E
R
R
N
A
E
Q
Y
K
D
Q
A
D
K
A
Site 127
S1869
K
D
Q
A
D
K
A
S
T
R
L
K
Q
L
K
Site 128
S1892
E
A
Q
R
A
N
A
S
R
R
K
L
Q
R
E
Site 129
T1906
E
L
E
D
A
T
E
T
A
D
A
M
N
R
E
Site 130
S1915
D
A
M
N
R
E
V
S
S
L
K
N
K
L
R
Site 131
S1916
A
M
N
R
E
V
S
S
L
K
N
K
L
R
R
Site 132
S1943
R
K
G
A
G
D
G
S
D
E
E
V
D
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation