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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOS2
Full Name:
Nitric oxide synthase, inducible
Alias:
EC 1.14.13.39; Hepatocyte NOS; HEP-NOS; Inducible; Inducible NOS; Nitric oxide synthase 2, inducible; NOS; NOS type II; NOS2A
Type:
Oxidoreductase, Amino Acid Metabolism group, Arginine and proline metabolism family
Mass (Da):
131117
Number AA:
1153
UniProt ID:
P35228
International Prot ID:
IPI00017304
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0010181
GO:0050661
PhosphoSite+
KinaseNET
Biological Process:
GO:0006527
GO:0050829
GO:0002227
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
F
K
T
K
F
H
Q
Y
A
M
N
G
E
K
D
Site 2
S37
K
A
P
C
A
T
S
S
P
V
T
Q
D
D
L
Site 3
T40
C
A
T
S
S
P
V
T
Q
D
D
L
Q
Y
H
Site 4
Y46
V
T
Q
D
D
L
Q
Y
H
N
L
S
K
Q
Q
Site 5
S50
D
L
Q
Y
H
N
L
S
K
Q
Q
N
E
S
P
Site 6
S56
L
S
K
Q
Q
N
E
S
P
Q
P
L
V
E
T
Site 7
T63
S
P
Q
P
L
V
E
T
G
K
K
S
P
E
S
Site 8
S67
L
V
E
T
G
K
K
S
P
E
S
L
V
K
L
Site 9
S70
T
G
K
K
S
P
E
S
L
V
K
L
D
A
T
Site 10
T77
S
L
V
K
L
D
A
T
P
L
S
S
P
R
H
Site 11
S80
K
L
D
A
T
P
L
S
S
P
R
H
V
R
I
Site 12
S81
L
D
A
T
P
L
S
S
P
R
H
V
R
I
K
Site 13
T99
S
G
M
T
F
Q
D
T
L
H
H
K
A
K
G
Site 14
T109
H
K
A
K
G
I
L
T
C
R
S
K
S
C
L
Site 15
S118
R
S
K
S
C
L
G
S
I
M
T
P
K
S
L
Site 16
T121
S
C
L
G
S
I
M
T
P
K
S
L
T
R
G
Site 17
S124
G
S
I
M
T
P
K
S
L
T
R
G
P
R
D
Site 18
T134
R
G
P
R
D
K
P
T
P
P
D
E
L
L
P
Site 19
Y150
A
I
E
F
V
N
Q
Y
Y
G
S
F
K
E
A
Site 20
Y151
I
E
F
V
N
Q
Y
Y
G
S
F
K
E
A
K
Site 21
S153
F
V
N
Q
Y
Y
G
S
F
K
E
A
K
I
E
Site 22
T170
L
A
R
V
E
A
V
T
K
E
I
E
T
T
G
Site 23
T176
V
T
K
E
I
E
T
T
G
T
Y
Q
L
T
G
Site 24
T178
K
E
I
E
T
T
G
T
Y
Q
L
T
G
D
E
Site 25
S218
V
F
D
A
R
S
C
S
T
A
R
E
M
F
E
Site 26
T235
C
R
H
V
R
Y
S
T
N
N
G
N
I
R
S
Site 27
T245
G
N
I
R
S
A
I
T
V
F
P
Q
R
S
D
Site 28
Y267
W
N
A
Q
L
I
R
Y
A
G
Y
Q
M
P
D
Site 29
Y270
Q
L
I
R
Y
A
G
Y
Q
M
P
D
G
S
I
Site 30
S276
G
Y
Q
M
P
D
G
S
I
R
G
D
P
A
N
Site 31
Y299
D
L
G
W
K
P
K
Y
G
R
F
D
V
V
P
Site 32
Y336
V
A
M
E
H
P
K
Y
E
W
F
R
E
L
E
Site 33
Y347
R
E
L
E
L
K
W
Y
A
L
P
A
V
A
N
Site 34
T403
G
R
R
M
G
L
E
T
H
K
L
A
S
L
W
Site 35
Y446
A
A
E
S
F
M
K
Y
M
Q
N
E
Y
R
S
Site 36
Y451
M
K
Y
M
Q
N
E
Y
R
S
R
G
G
C
P
Site 37
S453
Y
M
Q
N
E
Y
R
S
R
G
G
C
P
A
D
Site 38
T473
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
Site 39
Y483
F
H
Q
E
M
L
N
Y
V
L
S
P
F
Y
Y
Site 40
Y489
N
Y
V
L
S
P
F
Y
Y
Y
Q
V
E
A
W
Site 41
Y490
Y
V
L
S
P
F
Y
Y
Y
Q
V
E
A
W
K
Site 42
S550
F
A
T
E
T
G
K
S
E
A
L
A
W
D
L
Site 43
Y575
K
V
V
C
M
D
K
Y
R
L
S
C
L
E
E
Site 44
S578
C
M
D
K
Y
R
L
S
C
L
E
E
E
R
L
Site 45
S608
N
G
E
K
L
K
K
S
L
F
M
L
K
E
L
Site 46
Y621
E
L
N
N
K
F
R
Y
A
V
F
G
L
G
S
Site 47
S646
H
D
I
D
Q
K
L
S
H
L
G
A
S
Q
L
Site 48
T654
H
L
G
A
S
Q
L
T
P
M
G
E
G
D
E
Site 49
S663
M
G
E
G
D
E
L
S
G
Q
E
D
A
F
R
Site 50
T683
T
F
K
A
A
C
E
T
F
D
V
R
G
K
Q
Site 51
Y698
H
I
Q
I
P
K
L
Y
T
S
N
V
T
W
D
Site 52
S715
H
Y
R
L
V
Q
D
S
Q
P
L
D
L
S
K
Site 53
S721
D
S
Q
P
L
D
L
S
K
A
L
S
S
M
H
Site 54
S725
L
D
L
S
K
A
L
S
S
M
H
A
K
N
V
Site 55
S739
V
F
T
M
R
L
K
S
R
Q
N
L
Q
S
P
Site 56
S745
K
S
R
Q
N
L
Q
S
P
T
S
S
R
A
T
Site 57
S748
Q
N
L
Q
S
P
T
S
S
R
A
T
I
L
V
Site 58
S749
N
L
Q
S
P
T
S
S
R
A
T
I
L
V
E
Site 59
Y767
E
D
G
Q
G
L
N
Y
L
P
G
E
H
L
G
Site 60
T796
E
R
V
V
D
G
P
T
P
H
Q
T
V
R
L
Site 61
T800
D
G
P
T
P
H
Q
T
V
R
L
E
A
L
D
Site 62
S809
R
L
E
A
L
D
E
S
G
S
Y
W
V
S
D
Site 63
S811
E
A
L
D
E
S
G
S
Y
W
V
S
D
K
R
Site 64
Y812
A
L
D
E
S
G
S
Y
W
V
S
D
K
R
L
Site 65
S815
E
S
G
S
Y
W
V
S
D
K
R
L
P
P
C
Site 66
S823
D
K
R
L
P
P
C
S
L
S
Q
A
L
T
Y
Site 67
T851
Q
K
L
A
Q
V
A
T
E
E
P
E
R
Q
R
Site 68
Y868
A
L
C
Q
P
S
E
Y
S
K
W
K
F
T
N
Site 69
S876
S
K
W
K
F
T
N
S
P
T
F
L
E
V
L
Site 70
T878
W
K
F
T
N
S
P
T
F
L
E
V
L
E
E
Site 71
S892
E
F
P
S
L
R
V
S
A
G
F
L
L
S
Q
Site 72
S898
V
S
A
G
F
L
L
S
Q
L
P
I
L
K
P
Site 73
Y908
P
I
L
K
P
R
F
Y
S
I
S
S
S
R
D
Site 74
S909
I
L
K
P
R
F
Y
S
I
S
S
S
R
D
H
Site 75
S911
K
P
R
F
Y
S
I
S
S
S
R
D
H
T
P
Site 76
S912
P
R
F
Y
S
I
S
S
S
R
D
H
T
P
T
Site 77
S913
R
F
Y
S
I
S
S
S
R
D
H
T
P
T
E
Site 78
T917
I
S
S
S
R
D
H
T
P
T
E
I
H
L
T
Site 79
T919
S
S
R
D
H
T
P
T
E
I
H
L
T
V
A
Site 80
Y930
L
T
V
A
V
V
T
Y
H
T
R
D
G
Q
G
Site 81
T946
L
H
H
G
V
C
S
T
W
L
N
S
L
K
P
Site 82
S965
P
C
F
V
R
N
A
S
G
F
H
L
P
E
D
Site 83
S1000
W
Q
Q
R
L
H
D
S
Q
H
K
G
V
R
G
Site 84
T1011
G
V
R
G
G
R
M
T
L
V
F
G
C
R
R
Site 85
Y1025
R
P
D
E
D
H
I
Y
Q
E
E
M
L
E
M
Site 86
Y1045
L
H
A
V
H
T
A
Y
S
R
L
P
G
K
P
Site 87
Y1055
L
P
G
K
P
K
V
Y
V
Q
D
I
L
R
Q
Site 88
Y1080
H
K
E
P
G
H
L
Y
V
C
G
D
V
R
M
Site 89
Y1113
N
E
E
Q
V
E
D
Y
F
F
Q
L
K
S
Q
Site 90
Y1123
Q
L
K
S
Q
K
R
Y
H
E
D
I
F
G
A
Site 91
Y1134
I
F
G
A
V
F
P
Y
E
A
K
K
D
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation