KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GRK5
Full Name:
G protein-coupled receptor kinase 5
Alias:
EC 2.7.11.16; GPRK5; G-protein-coupled receptor kinase 5; Kinase GRK5
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.16; AGC group; GRK family; GRK subfamily
Mass (Da):
67787
Number AA:
590
UniProt ID:
P34947
International Prot ID:
IPI00414058
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004703
GO:0005543
PhosphoSite+
KinaseNET
Biological Process:
GO:0007188
GO:0006468
GO:0008277
Phosida
TranscriptoNet
STRING
Kinexus Products
G protein-coupled receptor kinase 5 pan-specific antibody AB-NK067-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK067-2#GRKtide KinSub - GRK protein kinase substrate peptide - Powder PE-01ACS95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACS95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
G
G
K
R
K
G
K
S
K
K
W
K
E
I
L
Site 2
S40
I
L
K
F
P
H
I
S
Q
C
E
D
L
R
R
Site 3
T48
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
Site 4
Y53
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
Q
Site 5
T73
L
F
R
Q
F
C
E
T
R
P
G
L
E
C
Y
Site 6
Y90
F
L
D
S
V
A
E
Y
E
V
T
P
D
E
K
Site 7
T93
S
V
A
E
Y
E
V
T
P
D
E
K
L
G
E
Site 8
Y109
G
K
E
I
M
T
K
Y
L
T
P
K
S
P
V
Site 9
S127
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Site 10
Y152
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
Site 11
Y161
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
Site 12
T185
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
Site 13
Y189
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
Site 14
Y212
V
R
A
T
G
K
M
Y
A
C
K
R
L
E
K
Site 15
Y253
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
Site 16
Y276
G
D
L
K
F
H
I
Y
N
M
G
N
P
G
F
Site 17
T307
E
D
L
H
R
E
N
T
V
Y
R
D
L
K
P
Site 18
Y309
L
H
R
E
N
T
V
Y
R
D
L
K
P
E
N
Site 19
Y322
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
Site 20
S328
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
Site 21
Y362
E
V
L
N
N
Q
R
Y
G
L
S
P
D
Y
W
Site 22
S365
N
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
Site 23
S383
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
Site 24
T404
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
Site 25
Y408
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
Site 26
S409
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
Site 27
S413
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
Site 28
S418
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
Site 29
T425
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
Site 30
S484
V
L
D
I
E
Q
F
S
T
V
K
G
V
N
L
Site 31
T485
L
D
I
E
Q
F
S
T
V
K
G
V
N
L
D
Site 32
T494
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
Site 33
Y499
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
Site 34
S500
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
Site 35
S503
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
Site 36
T504
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Site 37
S506
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
Site 38
S508
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
Site 39
T532
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
Site 40
S563
K
R
Q
H
Q
N
N
S
K
S
S
P
S
S
K
Site 41
S565
Q
H
Q
N
N
S
K
S
S
P
S
S
K
T
S
Site 42
S566
H
Q
N
N
S
K
S
S
P
S
S
K
T
S
F
Site 43
S568
N
N
S
K
S
S
P
S
S
K
T
S
F
N
H
Site 44
S569
N
S
K
S
S
P
S
S
K
T
S
F
N
H
H
Site 45
S572
S
S
P
S
S
K
T
S
F
N
H
H
I
N
S
Site 46
S579
S
F
N
H
H
I
N
S
N
H
V
S
S
N
S
Site 47
S583
H
I
N
S
N
H
V
S
S
N
S
T
G
S
S
Site 48
S584
I
N
S
N
H
V
S
S
N
S
T
G
S
S
_
Site 49
S586
S
N
H
V
S
S
N
S
T
G
S
S
_
_
_
Site 50
S589
V
S
S
N
S
T
G
S
S
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation