KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TTK
Full Name:
Dual specificity protein kinase TTK
Alias:
Cancer/testis antigen 96; CT96; EC 2.7.12.1; Esk1; Mps1; MPS1L1; Phosphotyrosine picked threonine-protein kinase; PYT; TTK protein kinase
Type:
Protein kinase, dual-specificity; EC 2.7.12.1; Other group; TTK family
Mass (Da):
97072
Number AA:
857
UniProt ID:
P33981
International Prot ID:
IPI00151170
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005819
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007094
GO:0007052
GO:0008284
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity protein kinase TTK T676 phosphosite-specific antibody AB-PK842#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK842#Dual specificity protein kinase TTK Y833+Y836 phosphosite-specific antibody AB-PK843#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK843#TTKSubtide - TTK protein kinase substrate peptide - Powder PE-01BJR90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BJR90#Dual specificity protein kinase TTK (D674-K680, human) pT676 phosphopeptide - Powder PE-04AQF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQF99#Dual specificity protein kinase TTK (K830-G839, human) pY833+pY836 phosphopeptide - Powder PE-04AQH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQH99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
E
S
E
D
L
S
G
R
E
Site 2
S7
_
M
E
S
E
D
L
S
G
R
E
L
T
I
D
Site 3
T12
D
L
S
G
R
E
L
T
I
D
S
I
M
N
K
Site 4
S15
G
R
E
L
T
I
D
S
I
M
N
K
V
R
D
Site 5
T33
K
F
K
N
E
D
L
T
D
E
L
S
L
N
K
Site 6
S37
E
D
L
T
D
E
L
S
L
N
K
I
S
A
D
Site 7
T45
L
N
K
I
S
A
D
T
T
D
N
S
G
T
V
Site 8
T46
N
K
I
S
A
D
T
T
D
N
S
G
T
V
N
Site 9
S49
S
A
D
T
T
D
N
S
G
T
V
N
Q
I
M
Site 10
S67
N
N
P
E
D
W
L
S
L
L
L
K
L
E
K
Site 11
S80
E
K
N
S
V
P
L
S
D
A
L
L
N
K
L
Site 12
S92
N
K
L
I
G
R
Y
S
Q
A
I
E
A
L
P
Site 13
Y103
E
A
L
P
P
D
K
Y
G
Q
N
E
S
F
A
Site 14
S108
D
K
Y
G
Q
N
E
S
F
A
R
I
Q
V
R
Site 15
Y131
E
P
D
D
A
R
D
Y
F
Q
M
A
R
A
N
Site 16
S155
S
F
A
Q
F
E
L
S
Q
G
N
V
K
K
S
Site 17
S162
S
Q
G
N
V
K
K
S
K
Q
L
L
Q
K
A
Site 18
S196
L
Q
K
K
Q
L
L
S
E
E
E
K
K
N
L
Site 19
S204
E
E
E
K
K
N
L
S
A
S
T
V
L
T
A
Site 20
S206
E
K
K
N
L
S
A
S
T
V
L
T
A
Q
E
Site 21
S214
T
V
L
T
A
Q
E
S
F
S
G
S
L
G
H
Site 22
S216
L
T
A
Q
E
S
F
S
G
S
L
G
H
L
Q
Site 23
S218
A
Q
E
S
F
S
G
S
L
G
H
L
Q
N
R
Site 24
S228
H
L
Q
N
R
N
N
S
C
D
S
R
G
Q
T
Site 25
T235
S
C
D
S
R
G
Q
T
T
K
A
R
F
L
Y
Site 26
T236
C
D
S
R
G
Q
T
T
K
A
R
F
L
Y
G
Site 27
Y242
T
T
K
A
R
F
L
Y
G
E
N
M
P
P
Q
Site 28
Y255
P
Q
D
A
E
I
G
Y
R
N
S
L
R
Q
T
Site 29
S258
A
E
I
G
Y
R
N
S
L
R
Q
T
N
K
T
Site 30
T262
Y
R
N
S
L
R
Q
T
N
K
T
K
Q
S
C
Site 31
T265
S
L
R
Q
T
N
K
T
K
Q
S
C
P
F
G
Site 32
S268
Q
T
N
K
T
K
Q
S
C
P
F
G
R
V
P
Site 33
S281
V
P
V
N
L
L
N
S
P
D
C
D
V
K
T
Site 34
T288
S
P
D
C
D
V
K
T
D
D
S
V
V
P
C
Site 35
T301
P
C
F
M
K
R
Q
T
S
R
S
E
C
R
D
Site 36
S302
C
F
M
K
R
Q
T
S
R
S
E
C
R
D
L
Site 37
S304
M
K
R
Q
T
S
R
S
E
C
R
D
L
V
V
Site 38
S314
R
D
L
V
V
P
G
S
K
P
S
G
N
D
S
Site 39
S317
V
V
P
G
S
K
P
S
G
N
D
S
C
E
L
Site 40
S321
S
K
P
S
G
N
D
S
C
E
L
R
N
L
K
Site 41
S329
C
E
L
R
N
L
K
S
V
Q
N
S
H
F
K
Site 42
S333
N
L
K
S
V
Q
N
S
H
F
K
E
P
L
V
Site 43
S341
H
F
K
E
P
L
V
S
D
E
K
S
S
E
L
Site 44
S345
P
L
V
S
D
E
K
S
S
E
L
I
I
T
D
Site 45
T351
K
S
S
E
L
I
I
T
D
S
I
T
L
K
N
Site 46
S353
S
E
L
I
I
T
D
S
I
T
L
K
N
K
T
Site 47
T355
L
I
I
T
D
S
I
T
L
K
N
K
T
E
S
Site 48
T360
S
I
T
L
K
N
K
T
E
S
S
L
L
A
K
Site 49
S362
T
L
K
N
K
T
E
S
S
L
L
A
K
L
E
Site 50
S363
L
K
N
K
T
E
S
S
L
L
A
K
L
E
E
Site 51
T371
L
L
A
K
L
E
E
T
K
E
Y
Q
E
P
E
Site 52
Y374
K
L
E
E
T
K
E
Y
Q
E
P
E
V
P
E
Site 53
S382
Q
E
P
E
V
P
E
S
N
Q
K
Q
W
Q
S
Site 54
S393
Q
W
Q
S
K
R
K
S
E
C
I
N
Q
N
P
Site 55
T423
V
N
T
E
Q
K
H
T
T
F
E
Q
P
V
F
Site 56
T424
N
T
E
Q
K
H
T
T
F
E
Q
P
V
F
S
Site 57
S431
T
F
E
Q
P
V
F
S
V
S
K
Q
S
P
P
Site 58
S433
E
Q
P
V
F
S
V
S
K
Q
S
P
P
I
S
Site 59
S436
V
F
S
V
S
K
Q
S
P
P
I
S
T
S
K
Site 60
S440
S
K
Q
S
P
P
I
S
T
S
K
W
F
D
P
Site 61
S442
Q
S
P
P
I
S
T
S
K
W
F
D
P
K
S
Site 62
S449
S
K
W
F
D
P
K
S
I
C
K
T
P
S
S
Site 63
T453
D
P
K
S
I
C
K
T
P
S
S
N
T
L
D
Site 64
S455
K
S
I
C
K
T
P
S
S
N
T
L
D
D
Y
Site 65
S456
S
I
C
K
T
P
S
S
N
T
L
D
D
Y
M
Site 66
Y462
S
S
N
T
L
D
D
Y
M
S
C
F
R
T
P
Site 67
T468
D
Y
M
S
C
F
R
T
P
V
V
K
N
D
F
Site 68
S482
F
P
P
A
C
Q
L
S
T
P
Y
G
Q
P
A
Site 69
T483
P
P
A
C
Q
L
S
T
P
Y
G
Q
P
A
C
Site 70
Y485
A
C
Q
L
S
T
P
Y
G
Q
P
A
C
F
Q
Site 71
T501
Q
Q
H
Q
I
L
A
T
P
L
Q
N
L
Q
V
Site 72
S511
Q
N
L
Q
V
L
A
S
S
S
A
N
E
C
I
Site 73
S519
S
S
A
N
E
C
I
S
V
K
G
R
I
Y
S
Site 74
S526
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
Site 75
S537
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Site 76
Y554
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
Site 77
T564
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
Site 78
S567
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
Site 79
Y568
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
Site 80
Y574
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
Site 81
S582
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
Site 82
Y589
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Site 83
Y591
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Site 84
Y599
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
Site 85
S611
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
Site 86
S618
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
Site 87
Y627
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
Site 88
T675
A
N
Q
M
Q
P
D
T
T
S
V
V
K
D
S
Site 89
T676
N
Q
M
Q
P
D
T
T
S
V
V
K
D
S
Q
Dual specificity protein kinase TTK T676 phosphosite-specific antibody AB-PK842#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK842#Dual specificity protein kinase TTK (D674-K680, human) pT676 phosphopeptide - Powder PE-04AQF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQF99
Site 90
S677
Q
M
Q
P
D
T
T
S
V
V
K
D
S
Q
V
Site 91
S682
T
T
S
V
V
K
D
S
Q
V
G
T
V
N
Y
Site 92
T686
V
K
D
S
Q
V
G
T
V
N
Y
M
P
P
E
Site 93
Y689
S
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
Site 94
S699
P
E
A
I
K
D
M
S
S
S
R
E
N
G
K
Site 95
S700
E
A
I
K
D
M
S
S
S
R
E
N
G
K
S
Site 96
S701
A
I
K
D
M
S
S
S
R
E
N
G
K
S
K
Site 97
S707
S
S
R
E
N
G
K
S
K
S
K
I
S
P
K
Site 98
S709
R
E
N
G
K
S
K
S
K
I
S
P
K
S
D
Site 99
S712
G
K
S
K
S
K
I
S
P
K
S
D
V
W
S
Site 100
S715
K
S
K
I
S
P
K
S
D
V
W
S
L
G
C
Site 101
S742
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
Site 102
S781
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
Site 103
Y790
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
H
P
Site 104
T795
H
P
Y
V
Q
I
Q
T
H
P
V
N
Q
M
A
Site 105
T805
V
N
Q
M
A
K
G
T
T
E
E
M
K
Y
V
Site 106
T806
N
Q
M
A
K
G
T
T
E
E
M
K
Y
V
L
Site 107
Y811
G
T
T
E
E
M
K
Y
V
L
G
Q
L
V
G
Site 108
S821
G
Q
L
V
G
L
N
S
P
N
S
I
L
K
A
Site 109
S824
V
G
L
N
S
P
N
S
I
L
K
A
A
K
T
Site 110
T831
S
I
L
K
A
A
K
T
L
Y
E
H
Y
S
G
Site 111
Y833
L
K
A
A
K
T
L
Y
E
H
Y
S
G
G
E
Dual specificity protein kinase TTK Y833+Y836 phosphosite-specific antibody AB-PK843#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK843#Dual specificity protein kinase TTK (K830-G839, human) pY833+pY836 phosphopeptide - Powder PE-04AQH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQH99
Site 112
Y836
A
K
T
L
Y
E
H
Y
S
G
G
E
S
H
N
Dual specificity protein kinase TTK Y833+Y836 phosphosite-specific antibody AB-PK843#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK843#Dual specificity protein kinase TTK (K830-G839, human) pY833+pY836 phosphopeptide - Powder PE-04AQH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQH99
Site 113
S837
K
T
L
Y
E
H
Y
S
G
G
E
S
H
N
S
Site 114
S841
E
H
Y
S
G
G
E
S
H
N
S
S
S
S
K
Site 115
S844
S
G
G
E
S
H
N
S
S
S
S
K
T
F
E
Site 116
S845
G
G
E
S
H
N
S
S
S
S
K
T
F
E
K
Site 117
S847
E
S
H
N
S
S
S
S
K
T
F
E
K
K
R
Site 118
T849
H
N
S
S
S
S
K
T
F
E
K
K
R
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation