PhosphoNET

           
Protein Info 
   
Short Name:  HIBADH
Full Name:  3-hydroxyisobutyrate dehydrogenase, mitochondrial
Alias:  3HIDH; 3-hydroxyisobutyrate dehydrogenase; EC 1.1.1.31; NS5ATP1
Type:  Oxidoreductase; EC 1.1.1.31; Amino Acid Metabolism - valine, leucine and isoleucine degradation
Mass (Da):  35329
Number AA:  336
UniProt ID:  P31937
International Prot ID:  IPI00013860
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005739     Uniprot OncoNet
Molecular Function:  GO:0008442  GO:0051287  GO:0004616 PhosphoSite+ KinaseNET
Biological Process:  GO:0055114  GO:0006098  GO:0006573 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S12LRLLGAASGLRYWSR
Site 2Y16GAASGLRYWSRRLRP
Site 3S18ASGLRYWSRRLRPAA
Site 4Y63KNLMKHGYPLIIYDV
Site 5S87DAGEQVVSSPADVAE
Site 6S88AGEQVVSSPADVAEK
Site 7T101EKADRIITMLPTSIN
Site 8S127LKKVKKGSLLIDSST
Site 9S132KGSLLIDSSTIDPAV
Site 10S160VFMDAPVSGGVGAAR
Site 11S248AKILNMSSGRCWSSD
Site 12S253MSSGRCWSSDTYNPV
Site 13S254SSGRCWSSDTYNPVP
Site 14T256GRCWSSDTYNPVPGV
Site 15Y257RCWSSDTYNPVPGVM
Site 16S269GVMDGVPSANNYQGG
Site 17Y273GVPSANNYQGGFGTT
Site 18S292DLGLAQDSATSTKSP
Site 19T294GLAQDSATSTKSPIL
Site 20T296AQDSATSTKSPILLG
Site 21S298DSATSTKSPILLGSL
Site 22S304KSPILLGSLAHQIYR
Site 23S325YSKKDFSSVFQFLRE
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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