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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RRM2
Full Name:
Ribonucleoside-diphosphate reductase subunit M2
Alias:
EC 1.17.4.1; Ribonucleotide reductase small subunit; RIR2; RR2
Type:
Other Amino Acids Metabolism - glutathione; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Oxidoreductase; EC 1.17.4.1
Mass (Da):
44878
Number AA:
389
UniProt ID:
P31350
International Prot ID:
IPI00011118
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0004748
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0009186
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
R
V
P
L
A
P
I
T
D
P
Q
Q
L
Q
L
Site 2
S20
D
P
Q
Q
L
Q
L
S
P
L
K
G
L
S
L
Site 3
S26
L
S
P
L
K
G
L
S
L
V
D
K
E
N
T
Site 4
T33
S
L
V
D
K
E
N
T
P
P
A
L
S
G
T
Site 5
S38
E
N
T
P
P
A
L
S
G
T
R
V
L
A
S
Site 6
S45
S
G
T
R
V
L
A
S
K
T
A
R
R
I
F
Site 7
T47
T
R
V
L
A
S
K
T
A
R
R
I
F
Q
E
Site 8
T60
Q
E
P
T
E
P
K
T
K
A
A
A
P
G
V
Site 9
S100
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
Site 10
S110
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
Site 11
Y125
S
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
Site 12
S150
E
N
L
V
E
R
F
S
Q
E
V
Q
I
T
E
Site 13
Y183
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
R
Site 14
Y221
I
G
D
K
E
A
T
Y
G
E
R
V
V
A
F
Site 15
S258
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
Site 16
S263
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
Site 17
S285
K
H
L
V
H
K
P
S
E
E
R
V
R
E
I
Site 18
T318
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
Site 19
Y369
F
E
K
R
V
G
E
Y
Q
R
M
G
V
M
S
Site 20
S376
Y
Q
R
M
G
V
M
S
S
P
T
E
N
S
F
Site 21
S377
Q
R
M
G
V
M
S
S
P
T
E
N
S
F
T
Site 22
T379
M
G
V
M
S
S
P
T
E
N
S
F
T
L
D
Site 23
S382
M
S
S
P
T
E
N
S
F
T
L
D
A
D
F
Site 24
T384
S
P
T
E
N
S
F
T
L
D
A
D
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation