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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLIP1
Full Name:
CAP-Gly domain-containing linker protein 1
Alias:
CAP-GLY domain containing linker protein 1; CLIP; CLIP170; CLIP-170; CYLN1; Cytoplasmic linker protein-170 alpha-2; Reed- Sternberg intermediate filament associated protein; REST; Restin; RSN
Type:
Cytoskeletal protein
Mass (Da):
162246
Number AA:
1438
UniProt ID:
P30622
International Prot ID:
IPI00027172
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005768
GO:0005882
GO:0000776
Uniprot
OncoNet
Molecular Function:
GO:0008017
GO:0003676
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
M
L
K
P
S
G
L
K
A
P
T
K
Site 2
S20
T
K
I
L
K
P
G
S
T
A
L
K
T
P
T
Site 3
T25
P
G
S
T
A
L
K
T
P
T
A
V
V
A
P
Site 4
S38
A
P
V
E
K
T
I
S
S
E
K
A
S
S
T
Site 5
S39
P
V
E
K
T
I
S
S
E
K
A
S
S
T
P
Site 6
S43
T
I
S
S
E
K
A
S
S
T
P
S
S
E
T
Site 7
S44
I
S
S
E
K
A
S
S
T
P
S
S
E
T
Q
Site 8
T45
S
S
E
K
A
S
S
T
P
S
S
E
T
Q
E
Site 9
S47
E
K
A
S
S
T
P
S
S
E
T
Q
E
E
F
Site 10
S48
K
A
S
S
T
P
S
S
E
T
Q
E
E
F
V
Site 11
S102
P
I
G
K
N
D
G
S
V
A
G
V
R
Y
F
Site 12
Y108
G
S
V
A
G
V
R
Y
F
Q
C
E
P
L
K
Site 13
T119
E
P
L
K
G
I
F
T
R
P
S
K
L
T
R
Site 14
S122
K
G
I
F
T
R
P
S
K
L
T
R
K
V
Q
Site 15
T125
F
T
R
P
S
K
L
T
R
K
V
Q
A
E
D
Site 16
T140
E
A
N
G
L
Q
T
T
P
A
S
R
A
T
S
Site 17
S143
G
L
Q
T
T
P
A
S
R
A
T
S
P
L
C
Site 18
T146
T
T
P
A
S
R
A
T
S
P
L
C
T
S
T
Site 19
S147
T
P
A
S
R
A
T
S
P
L
C
T
S
T
A
Site 20
T153
T
S
P
L
C
T
S
T
A
S
M
V
S
S
S
Site 21
S155
P
L
C
T
S
T
A
S
M
V
S
S
S
P
S
Site 22
S158
T
S
T
A
S
M
V
S
S
S
P
S
T
P
S
Site 23
S159
S
T
A
S
M
V
S
S
S
P
S
T
P
S
N
Site 24
S160
T
A
S
M
V
S
S
S
P
S
T
P
S
N
I
Site 25
S162
S
M
V
S
S
S
P
S
T
P
S
N
I
P
Q
Site 26
T163
M
V
S
S
S
P
S
T
P
S
N
I
P
Q
K
Site 27
S165
S
S
S
P
S
T
P
S
N
I
P
Q
K
P
S
Site 28
S172
S
N
I
P
Q
K
P
S
Q
P
A
A
K
E
P
Site 29
S180
Q
P
A
A
K
E
P
S
A
T
P
P
I
S
N
Site 30
T182
A
A
K
E
P
S
A
T
P
P
I
S
N
L
T
Site 31
S186
P
S
A
T
P
P
I
S
N
L
T
K
T
A
S
Site 32
T189
T
P
P
I
S
N
L
T
K
T
A
S
E
S
I
Site 33
T191
P
I
S
N
L
T
K
T
A
S
E
S
I
S
N
Site 34
S193
S
N
L
T
K
T
A
S
E
S
I
S
N
L
S
Site 35
S195
L
T
K
T
A
S
E
S
I
S
N
L
S
E
A
Site 36
S197
K
T
A
S
E
S
I
S
N
L
S
E
A
G
S
Site 37
S200
S
E
S
I
S
N
L
S
E
A
G
S
I
K
K
Site 38
S204
S
N
L
S
E
A
G
S
I
K
K
G
E
R
E
Site 39
T234
V
V
R
F
L
G
E
T
D
F
A
K
G
E
W
Site 40
Y262
G
A
V
A
G
T
R
Y
F
Q
C
Q
P
K
Y
Site 41
Y269
Y
F
Q
C
Q
P
K
Y
G
L
F
A
P
V
H
Site 42
T279
F
A
P
V
H
K
V
T
K
I
G
F
P
S
T
Site 43
S285
V
T
K
I
G
F
P
S
T
T
P
A
K
A
K
Site 44
T286
T
K
I
G
F
P
S
T
T
P
A
K
A
K
A
Site 45
T287
K
I
G
F
P
S
T
T
P
A
K
A
K
A
N
Site 46
T302
A
V
R
R
V
M
A
T
T
S
A
S
L
K
R
Site 47
T303
V
R
R
V
M
A
T
T
S
A
S
L
K
R
S
Site 48
S304
R
R
V
M
A
T
T
S
A
S
L
K
R
S
P
Site 49
S306
V
M
A
T
T
S
A
S
L
K
R
S
P
S
A
Site 50
S310
T
S
A
S
L
K
R
S
P
S
A
S
S
L
S
Site 51
S312
A
S
L
K
R
S
P
S
A
S
S
L
S
S
M
Site 52
S314
L
K
R
S
P
S
A
S
S
L
S
S
M
S
S
Site 53
S315
K
R
S
P
S
A
S
S
L
S
S
M
S
S
V
Site 54
S317
S
P
S
A
S
S
L
S
S
M
S
S
V
A
S
Site 55
S318
P
S
A
S
S
L
S
S
M
S
S
V
A
S
S
Site 56
S320
A
S
S
L
S
S
M
S
S
V
A
S
S
V
S
Site 57
S321
S
S
L
S
S
M
S
S
V
A
S
S
V
S
S
Site 58
S324
S
S
M
S
S
V
A
S
S
V
S
S
R
P
S
Site 59
S325
S
M
S
S
V
A
S
S
V
S
S
R
P
S
R
Site 60
S327
S
S
V
A
S
S
V
S
S
R
P
S
R
T
G
Site 61
S328
S
V
A
S
S
V
S
S
R
P
S
R
T
G
L
Site 62
S331
S
S
V
S
S
R
P
S
R
T
G
L
L
T
E
Site 63
T333
V
S
S
R
P
S
R
T
G
L
L
T
E
T
S
Site 64
T337
P
S
R
T
G
L
L
T
E
T
S
S
R
Y
A
Site 65
S340
T
G
L
L
T
E
T
S
S
R
Y
A
R
K
I
Site 66
S341
G
L
L
T
E
T
S
S
R
Y
A
R
K
I
S
Site 67
Y343
L
T
E
T
S
S
R
Y
A
R
K
I
S
G
T
Site 68
S348
S
R
Y
A
R
K
I
S
G
T
T
A
L
Q
E
Site 69
T350
Y
A
R
K
I
S
G
T
T
A
L
Q
E
A
L
Site 70
T351
A
R
K
I
S
G
T
T
A
L
Q
E
A
L
K
Site 71
T415
A
K
M
D
Q
L
R
T
M
V
E
A
A
D
R
Site 72
S449
Q
F
R
V
E
E
E
S
I
T
K
G
D
L
E
Site 73
T451
R
V
E
E
E
S
I
T
K
G
D
L
E
Q
K
Site 74
S459
K
G
D
L
E
Q
K
S
Q
I
S
E
D
P
E
Site 75
T470
E
D
P
E
N
T
Q
T
K
L
E
H
A
R
I
Site 76
S483
R
I
K
E
L
E
Q
S
L
L
F
E
K
T
K
Site 77
T489
Q
S
L
L
F
E
K
T
K
A
D
K
L
Q
R
Site 78
T501
L
Q
R
E
L
E
D
T
R
V
A
T
V
S
E
Site 79
T505
L
E
D
T
R
V
A
T
V
S
E
K
S
R
I
Site 80
S507
D
T
R
V
A
T
V
S
E
K
S
R
I
M
E
Site 81
S510
V
A
T
V
S
E
K
S
R
I
M
E
L
E
K
Site 82
S535
E
L
R
R
R
L
E
S
N
K
P
A
G
D
V
Site 83
S554
S
L
L
Q
E
I
S
S
L
Q
E
K
L
E
V
Site 84
T564
E
K
L
E
V
T
R
T
D
H
Q
R
E
I
T
Site 85
T571
T
D
H
Q
R
E
I
T
S
L
K
E
H
F
G
Site 86
T583
H
F
G
A
R
E
E
T
H
Q
K
E
I
K
A
Site 87
Y592
Q
K
E
I
K
A
L
Y
T
A
T
E
K
L
S
Site 88
S599
Y
T
A
T
E
K
L
S
K
E
N
E
S
L
K
Site 89
S604
K
L
S
K
E
N
E
S
L
K
S
K
L
E
H
Site 90
S607
K
E
N
E
S
L
K
S
K
L
E
H
A
N
K
Site 91
S617
E
H
A
N
K
E
N
S
D
V
I
A
L
W
K
Site 92
T629
L
W
K
S
K
L
E
T
A
I
A
S
H
Q
Q
Site 93
S644
A
M
E
E
L
K
V
S
F
S
K
G
L
G
T
Site 94
S646
E
E
L
K
V
S
F
S
K
G
L
G
T
E
T
Site 95
Y670
I
E
K
M
R
L
D
Y
Q
H
E
I
E
N
L
Site 96
S683
N
L
Q
N
Q
Q
D
S
E
R
A
A
H
A
K
Site 97
S709
V
I
K
E
K
E
N
S
L
E
A
I
R
S
K
Site 98
S715
N
S
L
E
A
I
R
S
K
L
D
K
A
E
D
Site 99
T731
H
L
V
E
M
E
D
T
L
N
K
L
Q
E
A
Site 100
S764
K
V
I
D
N
F
T
S
Q
L
K
A
T
E
E
Site 101
S783
L
D
A
L
R
K
A
S
S
E
G
K
S
E
M
Site 102
S784
D
A
L
R
K
A
S
S
E
G
K
S
E
M
K
Site 103
S788
K
A
S
S
E
G
K
S
E
M
K
K
L
R
Q
Site 104
S815
E
I
E
K
N
A
E
S
S
K
A
S
S
I
T
Site 105
S819
N
A
E
S
S
K
A
S
S
I
T
R
E
L
Q
Site 106
S820
A
E
S
S
K
A
S
S
I
T
R
E
L
Q
G
Site 107
T822
Q
G
R
E
L
K
L
T
N
L
Q
E
N
L
S
Site 108
T833
Q
G
R
E
L
K
L
T
N
L
Q
E
N
L
S
Site 109
S840
T
N
L
Q
E
N
L
S
E
V
S
Q
V
K
E
Site 110
S864
K
E
K
F
A
E
A
S
E
E
A
V
S
V
Q
Site 111
S869
E
A
S
E
E
A
V
S
V
Q
R
S
M
Q
E
Site 112
S873
E
A
V
S
V
Q
R
S
M
Q
E
T
V
N
K
Site 113
T877
V
Q
R
S
M
Q
E
T
V
N
K
L
H
Q
K
Site 114
S893
E
Q
F
N
M
L
S
S
D
L
E
K
L
R
E
Site 115
S937
I
A
E
I
M
K
M
S
G
D
N
S
S
Q
L
Site 116
S941
M
K
M
S
G
D
N
S
S
Q
L
T
K
M
N
Site 117
S942
K
M
S
G
D
N
S
S
Q
L
T
K
M
N
D
Site 118
T945
G
D
N
S
S
Q
L
T
K
M
N
D
E
L
R
Site 119
T966
E
E
L
Q
L
K
L
T
K
A
N
E
N
A
S
Site 120
S973
T
K
A
N
E
N
A
S
F
L
Q
K
S
I
E
Site 121
S978
N
A
S
F
L
Q
K
S
I
E
D
M
T
V
K
Site 122
T983
Q
K
S
I
E
D
M
T
V
K
A
E
Q
S
Q
Site 123
S1009
K
E
L
E
R
K
L
S
D
L
E
K
K
M
E
Site 124
Y1029
C
Q
E
L
K
A
R
Y
E
R
A
T
S
E
T
Site 125
T1033
K
A
R
Y
E
R
A
T
S
E
T
K
T
K
H
Site 126
S1034
A
R
Y
E
R
A
T
S
E
T
K
T
K
H
E
Site 127
T1038
R
A
T
S
E
T
K
T
K
H
E
E
I
L
Q
Site 128
S1066
K
G
A
R
E
E
N
S
G
L
L
Q
E
L
E
Site 129
T1105
M
T
K
E
K
T
E
T
L
A
S
L
E
D
T
Site 130
S1108
E
K
T
E
T
L
A
S
L
E
D
T
K
Q
T
Site 131
T1112
T
L
A
S
L
E
D
T
K
Q
T
N
A
K
L
Site 132
T1125
K
L
Q
N
E
L
D
T
L
K
E
N
N
L
K
Site 133
S1140
N
V
E
E
L
N
K
S
K
E
L
L
T
V
E
Site 134
T1145
N
K
S
K
E
L
L
T
V
E
N
Q
K
M
E
Site 135
T1160
E
F
R
K
E
I
E
T
L
K
Q
A
A
A
Q
Site 136
S1169
K
Q
A
A
A
Q
K
S
Q
Q
L
S
A
L
Q
Site 137
S1173
A
Q
K
S
Q
Q
L
S
A
L
Q
E
E
N
V
Site 138
S1189
L
A
E
E
L
G
R
S
R
D
E
V
T
S
H
Site 139
S1195
R
S
R
D
E
V
T
S
H
Q
K
L
E
E
E
Site 140
S1204
Q
K
L
E
E
E
R
S
V
L
N
N
Q
L
L
Site 141
S1218
L
E
M
K
K
R
E
S
K
F
I
K
D
A
D
Site 142
S1230
D
A
D
E
E
K
A
S
L
Q
K
S
I
S
I
Site 143
S1234
E
K
A
S
L
Q
K
S
I
S
I
T
S
A
L
Site 144
S1236
A
S
L
Q
K
S
I
S
I
T
S
A
L
L
T
Site 145
T1243
S
I
T
S
A
L
L
T
E
K
D
A
E
L
E
Site 146
T1257
E
K
L
R
N
E
V
T
V
L
R
G
E
N
A
Site 147
S1265
V
L
R
G
E
N
A
S
A
K
S
L
H
S
V
Site 148
S1268
G
E
N
A
S
A
K
S
L
H
S
V
V
Q
T
Site 149
S1271
A
S
A
K
S
L
H
S
V
V
Q
T
L
E
S
Site 150
T1275
S
L
H
S
V
V
Q
T
L
E
S
D
K
V
K
Site 151
S1278
S
V
V
Q
T
L
E
S
D
K
V
K
L
E
L
Site 152
S1302
K
E
N
K
R
Q
L
S
S
S
S
G
N
T
D
Site 153
S1303
E
N
K
R
Q
L
S
S
S
S
G
N
T
D
T
Site 154
S1304
N
K
R
Q
L
S
S
S
S
G
N
T
D
T
Q
Site 155
S1305
K
R
Q
L
S
S
S
S
G
N
T
D
T
Q
A
Site 156
T1308
L
S
S
S
S
G
N
T
D
T
Q
A
D
E
D
Site 157
T1310
S
S
S
G
N
T
D
T
Q
A
D
E
D
E
R
Site 158
S1321
E
D
E
R
A
Q
E
S
Q
I
D
F
L
N
S
Site 159
Y1362
N
G
D
D
L
N
N
Y
D
S
D
D
Q
E
K
Site 160
S1364
D
D
L
N
N
Y
D
S
D
D
Q
E
K
Q
S
Site 161
T1395
H
D
T
E
D
C
P
T
Q
A
Q
M
S
E
D
Site 162
S1400
C
P
T
Q
A
Q
M
S
E
D
P
P
H
S
T
Site 163
S1406
M
S
E
D
P
P
H
S
T
H
H
G
S
R
G
Site 164
T1407
S
E
D
P
P
H
S
T
H
H
G
S
R
G
E
Site 165
Y1418
S
R
G
E
E
R
P
Y
C
E
I
C
E
M
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation