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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDHA2
Full Name:
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Alias:
ODPAT; PDH2; PDHAL; PDHE1-A type II; pyruvate dehydrogenase (lipoamide) alpha 2; Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor
Type:
Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.4.1; Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle
Mass (Da):
42933
Number AA:
388
UniProt ID:
P29803
International Prot ID:
IPI00024087
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0005759
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0004739
GO:0004738
GO:0004739
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
GO:0055114
GO:0006006
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
R
R
V
A
Q
K
S
A
R
R
V
L
V
A
Site 2
S25
A
R
R
V
L
V
A
S
R
N
S
S
N
D
A
Site 3
S28
V
L
V
A
S
R
N
S
S
N
D
A
T
F
E
Site 4
S29
L
V
A
S
R
N
S
S
N
D
A
T
F
E
I
Site 5
T33
R
N
S
S
N
D
A
T
F
E
I
K
K
C
D
Site 6
Y42
E
I
K
K
C
D
L
Y
L
L
E
E
G
P
P
Site 7
Y62
T
R
A
E
G
L
K
Y
Y
R
M
M
L
T
V
Site 8
Y63
R
A
E
G
L
K
Y
Y
R
M
M
L
T
V
R
Site 9
T68
K
Y
Y
R
M
M
L
T
V
R
R
M
E
L
K
Site 10
Y80
E
L
K
A
D
Q
L
Y
K
Q
K
F
I
R
G
Site 11
S109
L
E
A
G
I
N
P
S
D
H
V
I
T
S
Y
Site 12
Y116
S
D
H
V
I
T
S
Y
R
A
H
G
V
C
Y
Site 13
Y123
Y
R
A
H
G
V
C
Y
T
R
G
L
S
V
R
Site 14
T137
R
S
I
L
A
E
L
T
G
R
R
G
G
C
A
Site 15
Y154
K
G
G
S
M
H
M
Y
T
K
N
F
Y
G
G
Site 16
Y192
D
E
I
C
L
T
L
Y
G
D
G
A
A
N
Q
Site 17
Y225
F
I
C
E
N
N
L
Y
G
M
G
T
S
T
E
Site 18
S230
N
L
Y
G
M
G
T
S
T
E
R
A
A
A
S
Site 19
T231
L
Y
G
M
G
T
S
T
E
R
A
A
A
S
P
Site 20
S237
S
T
E
R
A
A
A
S
P
D
Y
Y
K
R
G
Site 21
Y240
R
A
A
A
S
P
D
Y
Y
K
R
G
N
F
I
Site 22
Y241
A
A
A
S
P
D
Y
Y
K
R
G
N
F
I
P
Site 23
Y270
A
T
K
F
A
A
N
Y
C
R
S
G
K
G
P
Site 24
Y285
I
L
M
E
L
Q
T
Y
R
Y
H
G
H
S
M
Site 25
Y287
M
E
L
Q
T
Y
R
Y
H
G
H
S
M
S
D
Site 26
S291
T
Y
R
Y
H
G
H
S
M
S
D
P
G
V
S
Site 27
S293
R
Y
H
G
H
S
M
S
D
P
G
V
S
Y
R
Site 28
S298
S
M
S
D
P
G
V
S
Y
R
T
R
E
E
I
Site 29
Y299
M
S
D
P
G
V
S
Y
R
T
R
E
E
I
Q
Site 30
T301
D
P
G
V
S
Y
R
T
R
E
E
I
Q
E
V
Site 31
S310
E
E
I
Q
E
V
R
S
K
R
D
P
I
I
I
Site 32
T329
M
V
N
S
K
L
A
T
V
E
E
L
K
E
I
Site 33
T352
D
D
A
A
Q
F
A
T
T
D
P
E
P
H
L
Site 34
Y367
E
E
L
G
H
H
I
Y
S
S
D
S
S
F
E
Site 35
S368
E
L
G
H
H
I
Y
S
S
D
S
S
F
E
V
Site 36
S369
L
G
H
H
I
Y
S
S
D
S
S
F
E
V
R
Site 37
S372
H
I
Y
S
S
D
S
S
F
E
V
R
G
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation