|
|
|
|
|
|
|
|
|
|
|
|
Protein Info
|
|
|
|
|
|
Short Name:
|
Tyk2
|
|
Full Name:
|
Non-receptor tyrosine-protein kinase TYK2
|
|
Alias:
|
EC 2.7.10.2; JTK1; Kinase Tyk2; Tyrosine kinase 2
|
|
Type:
|
EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; JakA family
|
|
Mass (Da):
|
133650
|
|
Number AA:
|
1187
|
|
UniProt ID:
|
P29597
|
|
International Prot ID:
|
IPI00022353
|
|
Sequence:
|
Retrieve full protein sequence
|
|
|
|
|
GO Terms
|
|
External Links
|
Internal Links
|
|
|
|
|
|
Cellular Component:
|
GO:0005737
GO:0005856
GO:0016020
|
Uniprot
|
OncoNet
|
|
Molecular Function:
|
GO:0005524
GO:0004718
GO:0005131
|
PhosphoSite+
|
KinaseNET
|
|
|
Biological Process:
|
GO:0018108
GO:0007243
|
Phosida
|
TranscriptoNet
|
|
|
|
|
STRING
|
Kinexus Products
Protein-tyrosine kinase 2 (Jak-related) pan-specific antibody AB-NK181-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK181-3#Protein-tyrosine kinase 2 (Jak-related) pan-specific antibody AB-NK181-5#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK181-5#Protein-tyrosine kinase 2 (Jak-related) Y1054+Y1055 phosphosite-specific antibody AB-PK845#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK845#Protein-tyrosine kinase 2 (Jak-related) (S858-H872, human) peptide - Powder PE-01AVJ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AVJ95#Protein-tyrosine kinase 2 (Jak-related) (A886-I900, human) peptide - Powder PE-01AVK99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AVK99#Protein-tyrosine kinase 2 (Jak-related) (C1151-I1166, human) peptide - Powder PE-01AVL80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AVL80#Protein-tyrosine kinase 2 (Jak-related) (G1051-R1058, human) pY1054+pY1055 phosphopeptide - Powder PE-04AHX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHX99#Protein-tyrosine kinase 2 (Jak-related) (E289-D295, human) pY292 phosphopeptide - Powder PE-04AQJ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQJ99#Protein-tyrosine kinase 2 (Jak-related) (G1051-F1066, human) pY1054+pY1055+pS1063 phosphopeptide - Powder PE-04AXH80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AXH80#Protein-tyrosine kinase 2 (Jak-related) (G1051-V1057, human) pY1054 phosphopeptide - Powder PE-04BBJ00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04BBJ00
|
|
|
|
|
Info Box
|
|
A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
|
| Phosphosites | |
| |
| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| | Site 1 | S12 | H | W | G | M | A | R | G | S | K | P | V | G | D | G | A | |  |  | | | | | |  | | |
| | Site 2 | T45 | G | G | G | E | P | W | V | T | F | S | E | S | S | L | T | | | | | | | | | | | |
| | Site 3 | S47 | G | E | P | W | V | T | F | S | E | S | S | L | T | A | E | | | | | | | | | | | |
| | Site 4 | T52 | T | F | S | E | S | S | L | T | A | E | E | V | C | I | H | | | | | | | | | | | |
| | Site 5 | Y123 | N | P | R | E | P | A | V | Y | R | C | G | P | P | G | T | | | | | | | | | | | |
| | Site 6 | T130 | Y | R | C | G | P | P | G | T | E | A | S | S | D | Q | T | | | | | | | | | | | |
| | Site 7 | T137 | T | E | A | S | S | D | Q | T | A | Q | G | M | Q | L | L | | | | | | | | | | | |
| | Site 8 | S148 | M | Q | L | L | D | P | A | S | F | E | Y | L | F | E | Q | | | | | | | | | | | |
| | Site 9 | Y151 | L | D | P | A | S | F | E | Y | L | F | E | Q | G | K | H | | | | | | | | | | | |
| | Site 10 | S166 | E | F | V | N | D | V | A | S | L | W | E | L | S | T | E | | | | | | | | | | | |
| | Site 11 | S171 | V | A | S | L | W | E | L | S | T | E | E | E | I | H | H | | | | | | | | | | | |
| | Site 12 | T172 | A | S | L | W | E | L | S | T | E | E | E | I | H | H | F | | | | | | | | | | | |
| | Site 13 | S210 | E | E | V | A | K | K | T | S | F | K | D | C | I | P | R | | | | | | | | | | | |
| | Site 14 | S227 | R | R | H | I | R | Q | H | S | A | L | T | R | L | R | L | | | | | | | | | | | |
| | Site 15 | S251 | D | F | Q | P | G | R | L | S | Q | Q | M | V | M | V | K | | | | | | | | | | | |
| | Site 16 | T272 | R | L | A | P | R | F | G | T | E | R | V | P | V | C | H | | | | | | | | | | | |
| | Site 17 | Y292 | Q | A | E | G | E | P | C | Y | I | R | D | S | G | V | A | |  | | | |  Protein-tyrosine kinase 2 (Jak-related) (E289-D295, human) pY292 phosphopeptide - Powder PE-04AQJ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQJ99 | | | | | |
| | Site 18 | S296 | E | P | C | Y | I | R | D | S | G | V | A | P | T | D | P | | | | | | | | | | | |
| | Site 19 | S307 | P | T | D | P | G | P | E | S | A | A | G | P | P | T | H | | | | | | | | | | | |
| | Site 20 | T313 | E | S | A | A | G | P | P | T | H | E | V | L | V | T | G | | | | | | | | | | | |
| | Site 21 | S339 | E | V | N | K | E | E | G | S | S | G | S | S | G | R | N | | | | | | | | | | | |
| | Site 22 | S340 | V | N | K | E | E | G | S | S | G | S | S | G | R | N | P | | | | | | | | | | | |
| | Site 23 | S342 | K | E | E | G | S | S | G | S | S | G | R | N | P | Q | A | | | | | | | | | | | |
| | Site 24 | S343 | E | E | G | S | S | G | S | S | G | R | N | P | Q | A | S | | | | | | | | | | | |
| | Site 25 | S350 | S | G | R | N | P | Q | A | S | L | F | G | K | K | A | K | | | | | | | | | | | |
| | Site 26 | Y376 | P | R | E | P | L | W | A | Y | F | C | D | F | R | D | I | | | | | | | | | | | |
| | Site 27 | S406 | D | N | K | C | L | E | L | S | L | P | S | R | A | A | A | | | | | | | | | | | |
| | Site 28 | T427 | V | D | G | Y | F | R | L | T | A | D | S | S | H | Y | L | | | | | | | | | | | |
| | Site 29 | S431 | F | R | L | T | A | D | S | S | H | Y | L | C | H | E | V | | | | | | | | | | | |
| | Site 30 | Y433 | L | T | A | D | S | S | H | Y | L | C | H | E | V | A | P | | | | | | | | | | | |
| | Site 31 | S446 | A | P | P | R | L | V | M | S | I | R | D | G | I | H | G | | | | | | | | | | | |
| | Site 32 | Y471 | L | R | P | E | D | G | L | Y | L | I | H | W | S | T | S | | | | | | | | | | | |
| | Site 33 | T486 | H | P | Y | R | L | I | L | T | V | A | Q | R | S | Q | A | | | | | | | | | | | |
| | Site 34 | S491 | I | L | T | V | A | Q | R | S | Q | A | P | D | G | M | Q | | | | | | | | | | | |
| | Site 35 | S499 | Q | A | P | D | G | M | Q | S | L | R | L | R | K | F | P | | | | | | | | | | | |
| | Site 36 | S522 | V | L | E | G | W | G | R | S | F | P | S | V | R | E | L | | | | | | | | | | | |
| | Site 37 | S525 | G | W | G | R | S | F | P | S | V | R | E | L | G | A | A | | | | | | | | | | | |
| | Site 38 | S546 | R | A | G | D | D | C | F | S | L | R | R | C | C | L | P | | | | | | | | | | | |
| | Site 39 | S570 | I | M | R | G | A | R | A | S | P | R | T | L | N | L | S | | | | | | | | | | | |
| | Site 40 | T573 | G | A | R | A | S | P | R | T | L | N | L | S | Q | L | S | | | | | | | | | | | |
| | Site 41 | S577 | S | P | R | T | L | N | L | S | Q | L | S | F | H | R | V | | | | | | | | | | | |
| | Site 42 | S580 | T | L | N | L | S | Q | L | S | F | H | R | V | D | Q | K | | | | | | | | | | | |
| | Site 43 | S593 | Q | K | E | I | T | Q | L | S | H | L | G | Q | G | T | R | | | | | | | | | | | |
| | Site 44 | Y604 | Q | G | T | R | T | N | V | Y | E | G | R | L | R | V | E | | | | | | | | | | | |
| | Site 45 | S613 | G | R | L | R | V | E | G | S | G | D | P | E | E | G | K | | | | | | | | | | | |
| | Site 46 | S663 | Y | E | T | A | S | L | M | S | Q | V | S | H | T | H | L | | | | | | | | | | | |
| | Site 47 | Y689 | E | N | I | M | V | T | E | Y | V | E | H | G | P | L | D | | | | | | | | | | | |
| | Site 48 | S768 | G | V | G | L | G | A | L | S | R | E | E | R | V | E | R | | | | | | | | | | | |
| | Site 49 | S790 | C | L | P | G | G | A | N | S | L | S | T | A | M | D | K | | | | | | | | | | | |
| | Site 50 | S792 | P | G | G | A | N | S | L | S | T | A | M | D | K | W | G | | | | | | | | | | | |
| | Site 51 | S817 | D | G | E | A | P | L | Q | S | R | S | P | S | E | K | E | | | | | | | | | | | |
| | Site 52 | S819 | E | A | P | L | Q | S | R | S | P | S | E | K | E | H | F | | | | | | | | | | | |
| | Site 53 | S821 | P | L | Q | S | R | S | P | S | E | K | E | H | F | Y | Q | | | | | | | | | | | |
| | Site 54 | Y827 | P | S | E | K | E | H | F | Y | Q | R | Q | H | R | L | P | | | | | | | | | | | |
| | Site 55 | S837 | Q | H | R | L | P | E | P | S | C | P | Q | L | A | T | L | | | | | | | | | | | |
| | Site 56 | S846 | P | Q | L | A | T | L | T | S | Q | C | L | T | Y | E | P | | | | | | | | | | | |
| | Site 57 | T850 | T | L | T | S | Q | C | L | T | Y | E | P | T | Q | R | P | | | | | | | | | | | |
| | Site 58 | Y851 | L | T | S | Q | C | L | T | Y | E | P | T | Q | R | P | S | | | | | | | | | | | |
| | Site 59 | T854 | Q | C | L | T | Y | E | P | T | Q | R | P | S | F | R | T | | | | | | | | | | | |
| | Site 60 | S858 | Y | E | P | T | Q | R | P | S | F | R | T | I | L | R | D | | | | | | | | | | | |
| | Site 61 | T861 | T | Q | R | P | S | F | R | T | I | L | R | D | L | T | R | | | | | | | | | | | |
| | Site 62 | T867 | R | T | I | L | R | D | L | T | R | L | Q | P | H | N | L | | | | | | | | | | | |
| | Site 63 | T879 | H | N | L | A | D | V | L | T | V | N | P | D | S | P | A | | | | | | | | | | | |
| | Site 64 | S884 | V | L | T | V | N | P | D | S | P | A | S | D | P | T | V | | | | | | | | | | | |
| | Site 65 | S887 | V | N | P | D | S | P | A | S | D | P | T | V | F | H | K | | | | | | | | | | | |
| | Site 66 | T890 | D | S | P | A | S | D | P | T | V | F | H | K | R | Y | L | | | | | | | | | | | |
| | Site 67 | Y896 | P | T | V | F | H | K | R | Y | L | K | K | I | R | D | L | | | | | | | | | | | |
| | Site 68 | Y914 | H | F | G | K | V | S | L | Y | C | Y | D | P | T | N | D | | | | | | | | | | | |
| | Site 69 | Y916 | G | K | V | S | L | Y | C | Y | D | P | T | N | D | G | T | | | | | | | | | | | |
| | Site 70 | Y955 | I | D | I | L | R | T | L | Y | H | E | H | I | I | K | Y | | | | | | | | | | | |
| | Site 71 | Y962 | Y | H | E | H | I | I | K | Y | K | G | C | C | E | D | Q | | | | | | | | | | | |
| | Site 72 | S973 | C | E | D | Q | G | E | K | S | L | Q | L | V | M | E | Y | | | | | | | | | | | |
| | Site 73 | S985 | M | E | Y | V | P | L | G | S | L | R | D | Y | L | P | R | | | | | | | | | | | |
| | Site 74 | Y989 | P | L | G | S | L | R | D | Y | L | P | R | H | S | I | G | | | | | | | | | | | |
| | Site 75 | S994 | R | D | Y | L | P | R | H | S | I | G | L | A | Q | L | L | | | | | | | | | | | |
| | Site 76 | Y1019 | A | Y | L | H | A | Q | H | Y | I | H | R | D | L | A | A | | | | | | | | | | | |
| | Site 77 | Y1054 | A | V | P | E | G | H | E | Y | Y | R | V | R | E | D | G | | | | | | Protein-tyrosine kinase 2 (Jak-related) Y1054+Y1055 phosphosite-specific antibody AB-PK845#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK845#Protein-tyrosine kinase 2 (Jak-related) (G1051-R1058, human) pY1054+pY1055 phosphopeptide - Powder PE-04AHX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHX99#Protein-tyrosine kinase 2 (Jak-related) (G1051-F1066, human) pY1054+pY1055+pS1063 phosphopeptide - Powder PE-04AXH80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AXH80#Protein-tyrosine kinase 2 (Jak-related) (G1051-V1057, human) pY1054 phosphopeptide - Powder PE-04BBJ00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04BBJ00 | | | | | |
| | Site 78 | Y1055 | V | P | E | G | H | E | Y | Y | R | V | R | E | D | G | D | | | | | | Protein-tyrosine kinase 2 (Jak-related) Y1054+Y1055 phosphosite-specific antibody AB-PK845#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK845#Protein-tyrosine kinase 2 (Jak-related) (G1051-R1058, human) pY1054+pY1055 phosphopeptide - Powder PE-04AHX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHX99#Protein-tyrosine kinase 2 (Jak-related) (G1051-F1066, human) pY1054+pY1055+pS1063 phosphopeptide - Powder PE-04AXH80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AXH80 | | | | | |
| | Site 79 | S1063 | R | V | R | E | D | G | D | S | P | V | F | W | Y | A | P | | | | | | Protein-tyrosine kinase 2 (Jak-related) (G1051-F1066, human) pY1054+pY1055+pS1063 phosphopeptide - Powder PE-04AXH80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AXH80 | | | | | |
| | Site 80 | Y1079 | C | L | K | E | Y | K | F | Y | Y | A | S | D | V | W | S | | | | | | | | | | | |
| | Site 81 | Y1080 | L | K | E | Y | K | F | Y | Y | A | S | D | V | W | S | F | | | | | | | | | | | |
| | Site 82 | T1096 | V | T | L | Y | E | L | L | T | H | C | D | S | S | Q | S | | | | | | | | | | | |
| | Site 83 | S1100 | E | L | L | T | H | C | D | S | S | Q | S | P | P | T | K | | | | | | | | | | | |
| | Site 84 | S1101 | L | L | T | H | C | D | S | S | Q | S | P | P | T | K | F | | | | | | | | | | | |
| | Site 85 | S1103 | T | H | C | D | S | S | Q | S | P | P | T | K | F | L | E | | | | | | | | | | | |
| | Site 86 | T1125 | Q | M | T | V | L | R | L | T | E | L | L | E | R | G | E | | | | | | | | | | | |
| | Site 87 | Y1145 | D | K | C | P | C | E | V | Y | H | L | M | K | N | C | W | | | | | | | | | | | |
| | Site 88 | T1161 | T | E | A | S | F | R | P | T | F | E | N | L | I | P | I | | | | | | | | | | | |
| | Site 89 | T1171 | N | L | I | P | I | L | K | T | V | H | E | K | Y | Q | G | | | | | | | | | | | |
| | Site 90 | Y1176 | L | K | T | V | H | E | K | Y | Q | G | Q | A | P | S | V | | | | | | | | | | | |
|
|
|
|
|
|
|
|
Legend
|
|
|
|
Confirmed in mammals
|
|
Confirmed in related proteins or other species
|
|
|
Predicted by Kinexus P-Site Prediction algorithm
|
|
|
No data/link available
|
|
|
Link available
|
|
|
Products available
|
|
|
|
|
|
|
|
|
|
2019 Kinexus Bioinformatics Corporation
|
|