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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PML
Full Name:
Probable transcription factor PML
Alias:
MYL; Promyelocytic leukemia; RNF71; TRIM19; Tripartite motif protein 19; Tripartite motif-containing protein 19
Type:
Transcription factor; Tumor suppressor
Mass (Da):
97551
Number AA:
882
UniProt ID:
P29590
International Prot ID:
IPI00022348
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005737
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0050897
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006977
GO:0042771
GO:0008630
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
P
A
P
A
R
S
P
R
P
Q
Q
D
P
Site 2
T22
P
A
R
P
Q
E
P
T
M
P
P
P
E
T
P
Site 3
T28
P
T
M
P
P
P
E
T
P
S
E
G
R
Q
P
Site 4
S30
M
P
P
P
E
T
P
S
E
G
R
Q
P
S
P
Site 5
S36
P
S
E
G
R
Q
P
S
P
S
P
S
P
T
E
Site 6
S38
E
G
R
Q
P
S
P
S
P
S
P
T
E
R
A
Site 7
S40
R
Q
P
S
P
S
P
S
P
T
E
R
A
P
A
Site 8
T42
P
S
P
S
P
S
P
T
E
R
A
P
A
S
E
Site 9
S48
P
T
E
R
A
P
A
S
E
E
E
F
Q
F
L
Site 10
S111
L
D
N
V
F
F
E
S
L
Q
R
R
L
S
V
Site 11
S117
E
S
L
Q
R
R
L
S
V
Y
R
Q
I
V
D
Site 12
Y119
L
Q
R
R
L
S
V
Y
R
Q
I
V
D
A
Q
Site 13
S173
L
A
E
L
R
N
Q
S
V
R
E
F
L
D
G
Site 14
T184
F
L
D
G
T
R
K
T
N
N
I
F
C
S
N
Site 15
S190
K
T
N
N
I
F
C
S
N
P
N
H
R
T
P
Site 16
T196
C
S
N
P
N
H
R
T
P
T
L
T
S
I
Y
Site 17
T198
N
P
N
H
R
T
P
T
L
T
S
I
Y
C
R
Site 18
T200
N
H
R
T
P
T
L
T
S
I
Y
C
R
G
C
Site 19
Y203
T
P
T
L
T
S
I
Y
C
R
G
C
S
K
P
Site 20
S220
C
S
C
A
L
L
D
S
S
H
S
E
L
K
C
Site 21
S221
S
C
A
L
L
D
S
S
H
S
E
L
K
C
D
Site 22
S223
A
L
L
D
S
S
H
S
E
L
K
C
D
I
S
Site 23
S230
S
E
L
K
C
D
I
S
A
E
I
Q
Q
R
Q
Site 24
S252
Q
A
L
Q
E
Q
D
S
A
F
G
A
V
H
A
Site 25
T275
L
G
R
A
R
A
E
T
E
E
L
I
R
E
R
Site 26
Y305
L
E
A
V
D
A
R
Y
Q
R
D
Y
E
E
M
Site 27
Y309
D
A
R
Y
Q
R
D
Y
E
E
M
A
S
R
L
Site 28
S330
L
Q
R
I
R
T
G
S
A
L
V
Q
R
M
K
Site 29
S366
L
R
Q
E
E
P
Q
S
L
Q
A
A
V
R
T
Site 30
S387
K
V
R
L
Q
D
L
S
S
C
I
T
Q
G
K
Site 31
S388
V
R
L
Q
D
L
S
S
C
I
T
Q
G
K
D
Site 32
T391
Q
D
L
S
S
C
I
T
Q
G
K
D
A
A
V
Site 33
S399
Q
G
K
D
A
A
V
S
K
K
A
S
P
E
A
Site 34
S403
A
A
V
S
K
K
A
S
P
E
A
A
S
T
P
Site 35
S408
K
A
S
P
E
A
A
S
T
P
R
D
P
I
D
Site 36
T409
A
S
P
E
A
A
S
T
P
R
D
P
I
D
V
Site 37
Y464
F
S
I
K
G
P
S
Y
G
E
D
V
S
N
T
Site 38
S469
P
S
Y
G
E
D
V
S
N
T
T
T
A
Q
K
Site 39
T473
E
D
V
S
N
T
T
T
A
Q
K
R
K
C
S
Site 40
S480
T
A
Q
K
R
K
C
S
Q
T
Q
C
P
R
K
Site 41
T482
Q
K
R
K
C
S
Q
T
Q
C
P
R
K
V
I
Site 42
S504
K
E
A
R
L
A
R
S
S
P
E
Q
P
R
P
Site 43
S505
E
A
R
L
A
R
S
S
P
E
Q
P
R
P
S
Site 44
S512
S
P
E
Q
P
R
P
S
T
S
K
A
V
S
P
Site 45
T513
P
E
Q
P
R
P
S
T
S
K
A
V
S
P
P
Site 46
S514
E
Q
P
R
P
S
T
S
K
A
V
S
P
P
H
Site 47
S518
P
S
T
S
K
A
V
S
P
P
H
L
D
G
P
Site 48
S527
P
H
L
D
G
P
P
S
P
R
S
P
V
I
G
Site 49
S530
D
G
P
P
S
P
R
S
P
V
I
G
S
E
V
Site 50
S535
P
R
S
P
V
I
G
S
E
V
F
L
P
N
S
Site 51
S542
S
E
V
F
L
P
N
S
N
H
V
A
S
G
A
Site 52
S547
P
N
S
N
H
V
A
S
G
A
G
E
A
E
E
Site 53
S560
E
E
R
V
V
V
I
S
S
S
E
D
S
D
A
Site 54
S561
E
R
V
V
V
I
S
S
S
E
D
S
D
A
E
Site 55
S562
R
V
V
V
I
S
S
S
E
D
S
D
A
E
N
Site 56
S565
V
I
S
S
S
E
D
S
D
A
E
N
S
S
S
Site 57
S571
D
S
D
A
E
N
S
S
S
R
E
L
D
D
S
Site 58
S572
S
D
A
E
N
S
S
S
R
E
L
D
D
S
S
Site 59
S578
S
S
R
E
L
D
D
S
S
S
E
S
S
D
L
Site 60
S579
S
R
E
L
D
D
S
S
S
E
S
S
D
L
Q
Site 61
S580
R
E
L
D
D
S
S
S
E
S
S
D
L
Q
L
Site 62
S582
L
D
D
S
S
S
E
S
S
D
L
Q
L
E
G
Site 63
S583
D
D
S
S
S
E
S
S
D
L
Q
L
E
G
P
Site 64
T592
L
Q
L
E
G
P
S
T
L
R
V
L
D
E
N
Site 65
T621
D
L
K
I
D
N
E
T
Q
K
I
S
Q
L
A
Site 66
S625
D
N
E
T
Q
K
I
S
Q
L
A
A
V
N
R
Site 67
S722
R
E
R
V
P
G
A
S
S
F
K
L
K
N
L
Site 68
S723
E
R
V
P
G
A
S
S
F
K
L
K
N
L
A
Site 69
Y733
L
K
N
L
A
Q
T
Y
L
A
R
N
M
S
E
Site 70
S739
T
Y
L
A
R
N
M
S
E
R
S
A
M
A
A
Site 71
Y770
P
Q
L
A
Q
H
V
Y
P
F
S
S
L
Q
C
Site 72
S804
L
L
A
L
H
N
V
S
F
M
E
L
L
S
A
Site 73
S810
V
S
F
M
E
L
L
S
A
H
R
R
D
R
Q
Site 74
Y823
R
Q
G
G
L
K
K
Y
S
R
Y
L
S
L
Q
Site 75
S824
Q
G
G
L
K
K
Y
S
R
Y
L
S
L
Q
T
Site 76
Y826
G
L
K
K
Y
S
R
Y
L
S
L
Q
T
T
T
Site 77
S828
K
K
Y
S
R
Y
L
S
L
Q
T
T
T
L
P
Site 78
T832
R
Y
L
S
L
Q
T
T
T
L
P
P
A
Q
P
Site 79
S866
L
A
R
A
E
G
V
S
T
P
L
A
G
R
G
Site 80
T867
A
R
A
E
G
V
S
T
P
L
A
G
R
G
L
Site 81
S879
R
G
L
A
E
R
A
S
Q
Q
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation