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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rb-like 1
Full Name:
Retinoblastoma-like protein 1
Alias:
107 kDa retinoblastoma-associated protein; Cp107; P107; PRB1; RBL1; Retinoblastoma-like 1
Type:
Tumor suppressor; Transcription, coactivator/corepressor
Mass (Da):
120847
Number AA:
1068
UniProt ID:
P28749
International Prot ID:
IPI00005139
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0016568
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
A
E
A
L
D
D
F
T
A
I
R
G
N
Y
S
Site 2
Y49
F
T
A
I
R
G
N
Y
S
L
E
G
E
V
T
Site 3
S50
T
A
I
R
G
N
Y
S
L
E
G
E
V
T
H
Site 4
T88
E
G
N
C
V
S
L
T
R
I
L
R
S
A
K
Site 5
S93
S
L
T
R
I
L
R
S
A
K
L
S
L
I
Q
Site 6
S103
L
S
L
I
Q
F
F
S
K
M
K
K
W
M
D
Site 7
S132
L
E
R
N
F
E
V
S
T
V
I
F
K
K
Y
Site 8
T133
E
R
N
F
E
V
S
T
V
I
F
K
K
Y
E
Site 9
Y151
L
D
I
F
Q
N
P
Y
E
E
P
P
K
L
P
Site 10
S160
E
P
P
K
L
P
R
S
R
K
Q
R
R
I
P
Site 11
S169
K
Q
R
R
I
P
C
S
V
K
D
L
F
N
F
Site 12
S226
R
Q
D
L
L
N
P
S
F
K
G
L
P
S
D
Site 13
T236
G
L
P
S
D
F
H
T
A
D
F
T
A
S
E
Site 14
T240
D
F
H
T
A
D
F
T
A
S
E
E
P
P
C
Site 15
Y270
A
K
G
I
K
E
H
Y
F
K
P
Y
I
S
K
Site 16
Y274
K
E
H
Y
F
K
P
Y
I
S
K
L
F
D
R
Site 17
S293
G
E
C
L
L
D
L
S
S
F
T
D
N
S
K
Site 18
S294
E
C
L
L
D
L
S
S
F
T
D
N
S
K
A
Site 19
S299
L
S
S
F
T
D
N
S
K
A
V
N
K
E
Y
Site 20
Y306
S
K
A
V
N
K
E
Y
E
E
Y
V
L
T
V
Site 21
Y309
V
N
K
E
Y
E
E
Y
V
L
T
V
G
D
F
Site 22
T312
E
Y
E
E
Y
V
L
T
V
G
D
F
D
E
R
Site 23
T332
D
A
E
E
E
I
G
T
P
R
K
F
T
R
D
Site 24
T337
I
G
T
P
R
K
F
T
R
D
T
P
L
G
K
Site 25
T340
P
R
K
F
T
R
D
T
P
L
G
K
L
T
A
Site 26
S364
Q
H
F
E
K
K
R
S
F
A
P
S
T
P
L
Site 27
S368
K
K
R
S
F
A
P
S
T
P
L
T
G
R
R
Site 28
T369
K
R
S
F
A
P
S
T
P
L
T
G
R
R
Y
Site 29
T372
F
A
P
S
T
P
L
T
G
R
R
Y
L
R
E
Site 30
Y376
T
P
L
T
G
R
R
Y
L
R
E
K
E
A
V
Site 31
T385
R
E
K
E
A
V
I
T
P
V
A
S
A
T
Q
Site 32
S393
P
V
A
S
A
T
Q
S
V
S
R
L
Q
S
I
Site 33
S399
Q
S
V
S
R
L
Q
S
I
V
A
G
L
K
N
Site 34
T437
I
L
K
G
I
G
E
T
F
C
Q
H
Y
T
Q
Site 35
S445
F
C
Q
H
Y
T
Q
S
T
D
E
Q
P
G
S
Site 36
S452
S
T
D
E
Q
P
G
S
H
I
D
F
A
V
N
Site 37
T474
L
Y
Y
K
I
L
E
T
V
M
V
Q
E
T
R
Site 38
S489
R
L
H
G
M
D
M
S
V
L
L
E
Q
D
I
Site 39
S543
V
I
E
V
V
I
R
S
E
E
G
L
S
R
D
Site 40
S548
I
R
S
E
E
G
L
S
R
D
M
V
K
H
L
Site 41
S557
D
M
V
K
H
L
N
S
I
E
E
Q
I
L
E
Site 42
S565
I
E
E
Q
I
L
E
S
L
A
W
S
H
D
S
Site 43
S569
I
L
E
S
L
A
W
S
H
D
S
A
L
W
E
Site 44
S615
H
L
P
L
M
P
M
S
P
L
M
H
P
R
V
Site 45
T627
P
R
V
K
E
V
R
T
D
S
G
S
L
R
R
Site 46
S629
V
K
E
V
R
T
D
S
G
S
L
R
R
D
M
Site 47
S631
E
V
R
T
D
S
G
S
L
R
R
D
M
Q
P
Site 48
S640
R
R
D
M
Q
P
L
S
P
I
S
V
H
E
R
Site 49
S643
M
Q
P
L
S
P
I
S
V
H
E
R
Y
S
S
Site 50
Y648
P
I
S
V
H
E
R
Y
S
S
P
T
A
G
S
Site 51
S649
I
S
V
H
E
R
Y
S
S
P
T
A
G
S
A
Site 52
S650
S
V
H
E
R
Y
S
S
P
T
A
G
S
A
K
Site 53
T652
H
E
R
Y
S
S
P
T
A
G
S
A
K
R
R
Site 54
S655
Y
S
S
P
T
A
G
S
A
K
R
R
L
F
G
Site 55
S686
T
K
L
K
I
A
P
S
S
S
I
T
A
E
N
Site 56
S738
E
I
T
L
I
P
L
S
M
N
T
N
Q
E
S
Site 57
S745
S
M
N
T
N
Q
E
S
K
V
K
S
P
V
S
Site 58
S749
N
Q
E
S
K
V
K
S
P
V
S
L
T
A
H
Site 59
S757
P
V
S
L
T
A
H
S
L
I
G
A
S
P
K
Site 60
S762
A
H
S
L
I
G
A
S
P
K
Q
T
N
L
T
Site 61
T766
I
G
A
S
P
K
Q
T
N
L
T
K
A
Q
E
Site 62
T769
S
P
K
Q
T
N
L
T
K
A
Q
E
V
H
S
Site 63
T777
K
A
Q
E
V
H
S
T
G
I
N
R
P
K
R
Site 64
S787
N
R
P
K
R
T
G
S
L
A
L
F
Y
R
K
Site 65
Y796
A
L
F
Y
R
K
V
Y
H
L
A
S
V
R
L
Site 66
S800
R
K
V
Y
H
L
A
S
V
R
L
R
D
L
C
Site 67
S813
L
C
L
K
L
D
V
S
N
E
L
R
R
K
I
Site 68
T860
K
V
T
K
E
E
R
T
F
Q
E
I
M
K
S
Site 69
S876
R
N
Q
P
Q
A
N
S
H
V
Y
R
S
V
L
Site 70
Y879
P
Q
A
N
S
H
V
Y
R
S
V
L
L
K
S
Site 71
S881
A
N
S
H
V
Y
R
S
V
L
L
K
S
I
P
Site 72
Y894
I
P
R
E
V
V
A
Y
N
K
N
I
N
D
D
Site 73
T913
D
C
D
L
E
D
A
T
K
T
P
D
C
S
S
Site 74
T915
D
L
E
D
A
T
K
T
P
D
C
S
S
G
P
Site 75
S919
A
T
K
T
P
D
C
S
S
G
P
V
K
E
E
Site 76
S920
T
K
T
P
D
C
S
S
G
P
V
K
E
E
R
Site 77
Y934
R
G
D
L
I
K
F
Y
N
T
I
Y
V
G
R
Site 78
Y938
I
K
F
Y
N
T
I
Y
V
G
R
V
K
S
F
Site 79
Y949
V
K
S
F
A
L
K
Y
D
L
A
N
Q
D
H
Site 80
S964
M
M
D
A
P
P
L
S
P
F
P
H
I
K
Q
Site 81
S975
H
I
K
Q
Q
P
G
S
P
R
R
I
S
Q
Q
Site 82
S980
P
G
S
P
R
R
I
S
Q
Q
H
S
I
Y
I
Site 83
S984
R
R
I
S
Q
Q
H
S
I
Y
I
S
P
H
K
Site 84
Y986
I
S
Q
Q
H
S
I
Y
I
S
P
H
K
N
G
Site 85
S988
Q
Q
H
S
I
Y
I
S
P
H
K
N
G
S
G
Site 86
S994
I
S
P
H
K
N
G
S
G
L
T
P
R
S
A
Site 87
T997
H
K
N
G
S
G
L
T
P
R
S
A
L
L
Y
Site 88
S1000
G
S
G
L
T
P
R
S
A
L
L
Y
K
F
N
Site 89
Y1004
T
P
R
S
A
L
L
Y
K
F
N
G
S
P
S
Site 90
S1009
L
L
Y
K
F
N
G
S
P
S
K
S
L
K
D
Site 91
S1011
Y
K
F
N
G
S
P
S
K
S
L
K
D
I
N
Site 92
S1013
F
N
G
S
P
S
K
S
L
K
D
I
N
N
M
Site 93
S1037
K
R
V
I
A
I
D
S
D
A
E
S
P
A
K
Site 94
S1041
A
I
D
S
D
A
E
S
P
A
K
R
V
C
Q
Site 95
S1063
K
R
L
Q
D
V
V
S
E
R
A
N
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation