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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ChAT
Full Name:
Choline O-acetyltransferase
Alias:
CHAT; CHOACTase; Choline acetylase; choline acetyltransferase; CLAT
Type:
Lipid Metabolism - glycerophospholipid; EC 2.3.1.6; Acetyltransferase
Mass (Da):
82568
Number AA:
748
UniProt ID:
P28329
International Prot ID:
IPI00305227
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004102
PhosphoSite+
KinaseNET
Biological Process:
GO:0042136
Phosida
TranscriptoNet
STRING
Kinexus Products
Choline O-acetyltransferase pan-specific antibody AB-NN233-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN233-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
K
R
E
E
G
G
G
T
R
G
R
R
E
V
R
Site 2
S39
R
P
A
C
F
L
Q
S
G
G
R
G
D
P
G
Site 3
S58
P
A
G
N
P
G
C
S
P
H
P
R
A
A
T
Site 4
T65
S
P
H
P
R
A
A
T
R
P
P
P
L
P
A
Site 5
T74
P
P
P
L
P
A
H
T
P
A
H
T
P
E
W
Site 6
T78
P
A
H
T
P
A
H
T
P
E
W
C
G
A
A
Site 7
T109
P
A
P
G
L
T
K
T
P
I
L
E
K
V
P
Site 8
T123
P
R
K
M
A
A
K
T
P
S
S
E
E
S
G
Site 9
S125
K
M
A
A
K
T
P
S
S
E
E
S
G
L
P
Site 10
S126
M
A
A
K
T
P
S
S
E
E
S
G
L
P
K
Site 11
S129
K
T
P
S
S
E
E
S
G
L
P
K
L
P
V
Site 12
Y146
L
Q
Q
T
L
A
T
Y
L
Q
C
M
R
H
L
Site 13
S155
Q
C
M
R
H
L
V
S
E
E
Q
F
R
K
S
Site 14
S162
S
E
E
Q
F
R
K
S
Q
A
I
V
Q
Q
F
Site 15
T190
L
L
E
R
Q
E
K
T
A
N
W
V
S
E
Y
Site 16
Y203
E
Y
W
L
N
D
M
Y
L
N
N
R
L
A
L
Site 17
S251
S
Y
K
A
L
L
D
S
H
S
I
P
T
D
C
Site 18
S253
K
A
L
L
D
S
H
S
I
P
T
D
C
A
K
Site 19
S264
D
C
A
K
G
Q
L
S
G
Q
P
L
C
M
K
Site 20
Y273
Q
P
L
C
M
K
Q
Y
Y
G
L
F
S
S
Y
Site 21
Y274
P
L
C
M
K
Q
Y
Y
G
L
F
S
S
Y
R
Site 22
S278
K
Q
Y
Y
G
L
F
S
S
Y
R
L
P
G
H
Site 23
S279
Q
Y
Y
G
L
F
S
S
Y
R
L
P
G
H
T
Site 24
Y280
Y
Y
G
L
F
S
S
Y
R
L
P
G
H
T
Q
Site 25
T286
S
Y
R
L
P
G
H
T
Q
D
T
L
V
A
Q
Site 26
T289
L
P
G
H
T
Q
D
T
L
V
A
Q
N
S
S
Site 27
S325
V
I
N
F
R
R
L
S
E
G
D
L
F
T
Q
Site 28
T331
L
S
E
G
D
L
F
T
Q
L
R
K
I
V
K
Site 29
S341
R
K
I
V
K
M
A
S
N
E
D
E
R
L
P
Site 30
T354
L
P
P
I
G
L
L
T
S
D
G
R
S
E
W
Site 31
S355
P
P
I
G
L
L
T
S
D
G
R
S
E
W
A
Site 32
S359
L
L
T
S
D
G
R
S
E
W
A
E
A
R
T
Site 33
S372
R
T
V
L
V
K
D
S
T
N
R
D
S
L
D
Site 34
T373
T
V
L
V
K
D
S
T
N
R
D
S
L
D
M
Site 35
S377
K
D
S
T
N
R
D
S
L
D
M
I
E
R
C
Site 36
S399
A
P
G
G
V
E
L
S
D
T
H
R
A
L
Q
Site 37
T401
G
G
V
E
L
S
D
T
H
R
A
L
Q
L
L
Site 38
Y413
Q
L
L
H
G
G
G
Y
S
K
N
G
A
N
R
Site 39
S414
L
L
H
G
G
G
Y
S
K
N
G
A
N
R
W
Site 40
Y422
K
N
G
A
N
R
W
Y
D
K
S
L
Q
F
V
Site 41
T462
E
H
L
L
K
H
M
T
Q
S
S
R
K
L
I
Site 42
S464
L
L
K
H
M
T
Q
S
S
R
K
L
I
R
A
Site 43
S465
L
K
H
M
T
Q
S
S
R
K
L
I
R
A
D
Site 44
S473
R
K
L
I
R
A
D
S
V
S
E
L
P
A
P
Site 45
S475
L
I
R
A
D
S
V
S
E
L
P
A
P
R
R
Site 46
S488
R
R
L
R
W
K
C
S
P
E
I
Q
G
H
L
Site 47
S497
E
I
Q
G
H
L
A
S
S
A
E
K
L
Q
R
Site 48
Y514
K
N
L
D
F
I
V
Y
K
F
D
N
Y
G
K
Site 49
Y519
I
V
Y
K
F
D
N
Y
G
K
T
F
I
K
K
Site 50
T522
K
F
D
N
Y
G
K
T
F
I
K
K
Q
K
C
Site 51
S530
F
I
K
K
Q
K
C
S
P
D
A
F
I
Q
V
Site 52
T553
L
H
R
R
L
V
P
T
Y
E
S
A
S
I
R
Site 53
Y554
H
R
R
L
V
P
T
Y
E
S
A
S
I
R
R
Site 54
S558
V
P
T
Y
E
S
A
S
I
R
R
F
Q
E
G
Site 55
T574
V
D
N
I
R
S
A
T
P
E
A
L
A
F
V
Site 56
S594
H
K
A
A
V
P
A
S
E
K
L
L
L
L
K
Site 57
Y647
E
M
F
M
D
E
T
Y
L
M
S
N
R
F
V
Site 58
S650
M
D
E
T
Y
L
M
S
N
R
F
V
L
S
T
Site 59
S656
M
S
N
R
F
V
L
S
T
S
Q
V
P
T
T
Site 60
T657
S
N
R
F
V
L
S
T
S
Q
V
P
T
T
T
Site 61
S658
N
R
F
V
L
S
T
S
Q
V
P
T
T
T
E
Site 62
T663
S
T
S
Q
V
P
T
T
T
E
M
F
C
C
Y
Site 63
Y682
P
N
G
Y
G
A
C
Y
N
P
Q
P
E
T
I
Site 64
S698
F
C
I
S
S
F
H
S
C
K
E
T
S
S
S
Site 65
T702
S
F
H
S
C
K
E
T
S
S
S
K
F
A
K
Site 66
S705
S
C
K
E
T
S
S
S
K
F
A
K
A
V
E
Site 67
S723
I
D
M
R
D
L
C
S
L
L
P
P
T
E
S
Site 68
S743
K
E
K
A
T
R
P
S
Q
G
H
Q
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation