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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
5-HT(2A)
Full Name:
5-hydroxytryptamine receptor 2A
Alias:
5H2A; 5-HT-2; 5HT2A; 5-HT-2A; HTR2; HTR2A; Serotonin receptor
Type:
Receptor - G protein-coupled; Plasma membrane, iIntegral plasma membrane protein; cytoplasm, dendrite protein
Mass (Da):
52603
Number AA:
471
UniProt ID:
P28223
International Prot ID:
IPI00002185
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0051378
GO:0004993
PhosphoSite+
KinaseNET
Biological Process:
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
I
L
C
E
E
N
T
S
L
S
S
T
T
N
S
Site 2
S12
C
E
E
N
T
S
L
S
S
T
T
N
S
L
M
Site 3
S13
E
E
N
T
S
L
S
S
T
T
N
S
L
M
Q
Site 4
T14
E
N
T
S
L
S
S
T
T
N
S
L
M
Q
L
Site 5
S17
S
L
S
S
T
T
N
S
L
M
Q
L
N
D
D
Site 6
T25
L
M
Q
L
N
D
D
T
R
L
Y
S
N
D
F
Site 7
Y28
L
N
D
D
T
R
L
Y
S
N
D
F
N
S
G
Site 8
S29
N
D
D
T
R
L
Y
S
N
D
F
N
S
G
E
Site 9
S34
L
Y
S
N
D
F
N
S
G
E
A
N
T
S
D
Site 10
S40
N
S
G
E
A
N
T
S
D
A
F
N
W
T
V
Site 11
S49
A
F
N
W
T
V
D
S
E
N
R
T
N
L
S
Site 12
T53
T
V
D
S
E
N
R
T
N
L
S
C
E
G
C
Site 13
S56
S
E
N
R
T
N
L
S
C
E
G
C
L
S
P
Site 14
Y139
M
L
T
I
L
Y
G
Y
R
W
P
L
P
S
K
Site 15
S184
I
Q
N
P
I
H
H
S
R
F
N
S
R
T
K
Site 16
S188
I
H
H
S
R
F
N
S
R
T
K
A
F
L
K
Site 17
T190
H
S
R
F
N
S
R
T
K
A
F
L
K
I
I
Site 18
S219
V
F
G
L
Q
D
D
S
K
V
F
K
E
G
S
Site 19
T266
K
S
L
Q
K
E
A
T
L
C
V
S
D
L
G
Site 20
S280
G
T
R
A
K
L
A
S
F
S
F
L
P
Q
S
Site 21
S287
S
F
S
F
L
P
Q
S
S
L
S
S
E
K
L
Site 22
S288
F
S
F
L
P
Q
S
S
L
S
S
E
K
L
F
Site 23
S290
F
L
P
Q
S
S
L
S
S
E
K
L
F
Q
R
Site 24
S291
L
P
Q
S
S
L
S
S
E
K
L
F
Q
R
S
Site 25
S298
S
E
K
L
F
Q
R
S
I
H
R
E
P
G
S
Site 26
S305
S
I
H
R
E
P
G
S
Y
T
G
R
R
T
M
Site 27
Y306
I
H
R
E
P
G
S
Y
T
G
R
R
T
M
Q
Site 28
T307
H
R
E
P
G
S
Y
T
G
R
R
T
M
Q
S
Site 29
T311
G
S
Y
T
G
R
R
T
M
Q
S
I
S
N
E
Site 30
S314
T
G
R
R
T
M
Q
S
I
S
N
E
Q
K
A
Site 31
S316
R
R
T
M
Q
S
I
S
N
E
Q
K
A
C
K
Site 32
T381
A
V
N
P
L
V
Y
T
L
F
N
K
T
Y
R
Site 33
T386
V
Y
T
L
F
N
K
T
Y
R
S
A
F
S
R
Site 34
Y387
Y
T
L
F
N
K
T
Y
R
S
A
F
S
R
Y
Site 35
S389
L
F
N
K
T
Y
R
S
A
F
S
R
Y
I
Q
Site 36
Y399
S
R
Y
I
Q
C
Q
Y
K
E
N
K
K
P
L
Site 37
S422
P
A
L
A
Y
K
S
S
Q
L
Q
M
G
Q
K
Site 38
T438
N
S
K
Q
D
A
K
T
T
D
N
D
C
S
M
Site 39
T439
S
K
Q
D
A
K
T
T
D
N
D
C
S
M
V
Site 40
S453
V
A
L
G
K
Q
H
S
E
E
A
S
K
D
N
Site 41
S457
K
Q
H
S
E
E
A
S
K
D
N
S
D
G
V
Site 42
S461
E
E
A
S
K
D
N
S
D
G
V
N
E
K
V
Site 43
S469
D
G
V
N
E
K
V
S
C
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation