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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAD
Full Name:
CAD protein
Alias:
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; PYR1
Type:
EC 6.3.5.5; EC 2.1.3.2; Ligase; Nucleotide Metabolism - pyrimidine; EC 3.5.2.3; Transferase; Hydrolase; Amino Acid Metabolism - alanine, aspartate and glutamate
Mass (Da):
242984
Number AA:
2225
UniProt ID:
P27708
International Prot ID:
IPI00301263
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0070335
GO:0004070
PhosphoSite+
KinaseNET
Biological Process:
GO:0006207
GO:0006541
GO:0018107
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
L
V
L
E
D
G
S
V
L
R
G
Q
P
F
Site 2
Y36
F
Q
T
G
M
V
G
Y
P
E
A
L
T
D
P
Site 3
T41
V
G
Y
P
E
A
L
T
D
P
S
Y
K
A
Q
Site 4
Y60
T
Y
P
L
I
G
N
Y
G
I
P
P
D
E
M
Site 5
T94
V
V
G
E
C
C
P
T
P
S
H
W
S
A
T
Site 6
S99
C
P
T
P
S
H
W
S
A
T
R
T
L
H
E
Site 7
T121
P
G
L
Q
G
V
D
T
R
E
L
T
K
K
L
Site 8
T125
G
V
D
T
R
E
L
T
K
K
L
R
E
Q
G
Site 9
S133
K
K
L
R
E
Q
G
S
L
L
G
K
L
V
Q
Site 10
T143
G
K
L
V
Q
N
G
T
E
P
S
S
L
P
F
Site 11
S146
V
Q
N
G
T
E
P
S
S
L
P
F
L
D
P
Site 12
S147
Q
N
G
T
E
P
S
S
L
P
F
L
D
P
N
Site 13
T166
V
P
E
V
S
I
K
T
P
R
V
F
N
T
G
Site 14
T172
K
T
P
R
V
F
N
T
G
G
A
P
R
I
L
Site 15
S211
P
W
D
H
A
L
D
S
Q
E
Y
E
G
L
F
Site 16
Y214
H
A
L
D
S
Q
E
Y
E
G
L
F
L
S
N
Site 17
S220
E
Y
E
G
L
F
L
S
N
G
P
G
D
P
A
Site 18
S228
N
G
P
G
D
P
A
S
Y
P
S
V
V
S
T
Site 19
Y229
G
P
G
D
P
A
S
Y
P
S
V
V
S
T
L
Site 20
S231
G
D
P
A
S
Y
P
S
V
V
S
T
L
S
R
Site 21
S237
P
S
V
V
S
T
L
S
R
V
L
S
E
P
N
Site 22
S241
S
T
L
S
R
V
L
S
E
P
N
P
R
P
V
Site 23
Y267
L
A
I
G
A
K
T
Y
K
M
R
Y
G
N
R
Site 24
Y271
A
K
T
Y
K
M
R
Y
G
N
R
G
H
N
Q
Site 25
T291
G
S
G
R
C
F
L
T
S
Q
N
H
G
F
A
Site 26
S292
S
G
R
C
F
L
T
S
Q
N
H
G
F
A
V
Site 27
S303
G
F
A
V
E
T
D
S
L
P
A
D
W
A
P
Site 28
S327
N
E
G
I
V
H
N
S
L
P
F
F
S
V
Q
Site 29
S344
P
E
H
Q
A
G
P
S
D
M
E
L
L
F
D
Site 30
T369
A
G
N
P
G
G
Q
T
V
R
E
R
L
T
E
Site 31
T375
Q
T
V
R
E
R
L
T
E
R
L
C
P
P
G
Site 32
S388
P
G
I
P
T
P
G
S
G
L
P
P
P
R
K
Site 33
Y414
G
Q
A
G
E
F
D
Y
S
G
S
Q
A
I
K
Site 34
S415
Q
A
G
E
F
D
Y
S
G
S
Q
A
I
K
A
Site 35
S417
G
E
F
D
Y
S
G
S
Q
A
I
K
A
L
K
Site 36
T430
L
K
E
E
N
I
Q
T
L
L
I
N
P
N
I
Site 37
T456
K
V
Y
F
L
P
I
T
P
H
Y
V
T
Q
V
Site 38
T475
R
P
D
G
V
L
L
T
F
G
G
Q
T
A
L
Site 39
T504
Y
G
V
R
V
L
G
T
P
V
E
T
I
E
L
Site 40
S537
A
P
S
E
A
A
N
S
L
E
Q
A
Q
A
A
Site 41
S565
F
A
L
G
G
L
G
S
G
F
A
S
N
R
E
Site 42
S569
G
L
G
S
G
F
A
S
N
R
E
E
L
S
A
Site 43
S593
S
Q
V
L
V
D
K
S
L
K
G
W
K
E
I
Site 44
Y602
K
G
W
K
E
I
E
Y
E
V
V
R
D
A
Y
Site 45
Y645
Q
T
L
N
D
R
E
Y
Q
L
L
R
Q
T
A
Site 46
T651
E
Y
Q
L
L
R
Q
T
A
I
K
V
T
Q
H
Site 47
Y669
V
G
E
C
N
V
Q
Y
A
L
N
P
E
S
E
Site 48
Y678
L
N
P
E
S
E
Q
Y
Y
I
I
E
V
N
A
Site 49
Y679
N
P
E
S
E
Q
Y
Y
I
I
E
V
N
A
R
Site 50
S688
I
E
V
N
A
R
L
S
R
S
S
A
L
A
S
Site 51
S690
V
N
A
R
L
S
R
S
S
A
L
A
S
K
A
Site 52
S691
N
A
R
L
S
R
S
S
A
L
A
S
K
A
T
Site 53
S695
S
R
S
S
A
L
A
S
K
A
T
G
Y
P
L
Site 54
S721
P
L
P
E
L
R
N
S
V
T
G
G
T
A
A
Site 55
Y735
A
F
E
P
S
V
D
Y
C
V
V
K
I
P
R
Site 56
S746
K
I
P
R
W
D
L
S
K
F
L
R
V
S
T
Site 57
T753
S
K
F
L
R
V
S
T
K
I
G
S
C
M
K
Site 58
S757
R
V
S
T
K
I
G
S
C
M
K
S
V
G
E
Site 59
S761
K
I
G
S
C
M
K
S
V
G
E
V
M
G
I
Site 60
S771
E
V
M
G
I
G
R
S
F
E
E
A
F
Q
K
Site 61
T793
N
C
V
G
F
D
H
T
V
K
P
V
S
D
M
Site 62
S798
D
H
T
V
K
P
V
S
D
M
E
L
E
T
P
Site 63
T804
V
S
D
M
E
L
E
T
P
T
D
K
R
I
F
Site 64
Y827
G
Y
S
V
D
R
L
Y
E
L
T
R
I
D
R
Site 65
T830
V
D
R
L
Y
E
L
T
R
I
D
R
W
F
L
Site 66
T883
I
A
L
A
V
L
S
T
E
L
A
V
R
K
L
Site 67
Y916
E
W
P
A
Q
T
N
Y
L
Y
L
T
Y
W
G
Site 68
Y918
P
A
Q
T
N
Y
L
Y
L
T
Y
W
G
T
T
Site 69
T929
W
G
T
T
H
D
L
T
F
R
T
P
H
V
L
Site 70
S947
S
G
V
Y
R
I
G
S
S
V
E
F
D
W
C
Site 71
Y967
Q
Q
L
R
K
M
G
Y
K
T
I
M
V
N
Y
Site 72
T978
M
V
N
Y
N
P
E
T
V
S
T
D
Y
D
M
Site 73
Y983
P
E
T
V
S
T
D
Y
D
M
C
D
R
L
Y
Site 74
Y990
Y
D
M
C
D
R
L
Y
F
D
E
I
S
F
E
Site 75
Y1003
F
E
V
V
M
D
I
Y
E
L
E
N
P
E
G
Site 76
S1014
N
P
E
G
V
I
L
S
M
G
G
Q
L
P
N
Site 77
T1037
Q
Q
C
R
V
L
G
T
S
P
E
A
I
D
S
Site 78
S1038
Q
C
R
V
L
G
T
S
P
E
A
I
D
S
A
Site 79
S1044
T
S
P
E
A
I
D
S
A
E
N
R
F
K
F
Site 80
T1057
K
F
S
R
L
L
D
T
I
G
I
S
Q
P
Q
Site 81
S1061
L
L
D
T
I
G
I
S
Q
P
Q
W
R
E
L
Site 82
S1069
Q
P
Q
W
R
E
L
S
D
L
E
S
A
R
Q
Site 83
S1073
R
E
L
S
D
L
E
S
A
R
Q
F
C
Q
T
Site 84
S1112
G
D
L
E
R
F
L
S
S
A
A
A
V
S
K
Site 85
T1166
G
V
H
S
G
D
A
T
L
V
T
P
P
Q
D
Site 86
T1169
S
G
D
A
T
L
V
T
P
P
Q
D
I
T
A
Site 87
T1178
P
Q
D
I
T
A
K
T
L
E
R
I
K
A
I
Site 88
S1220
I
E
C
N
V
R
V
S
R
S
F
P
F
V
S
Site 89
S1222
C
N
V
R
V
S
R
S
F
P
F
V
S
K
T
Site 90
S1267
G
V
K
V
P
Q
F
S
F
S
R
L
A
G
A
Site 91
Y1299
G
E
S
R
C
E
A
Y
L
K
A
M
L
S
T
Site 92
T1318
P
K
K
N
I
L
L
T
I
G
S
Y
K
N
K
Site 93
S1321
N
I
L
L
T
I
G
S
Y
K
N
K
S
E
L
Site 94
S1326
I
G
S
Y
K
N
K
S
E
L
L
P
T
V
R
Site 95
T1331
N
K
S
E
L
L
P
T
V
R
L
L
E
S
L
Site 96
Y1343
E
S
L
G
Y
S
L
Y
A
S
L
G
T
A
D
Site 97
Y1352
S
L
G
T
A
D
F
Y
T
E
H
G
V
K
V
Site 98
T1353
L
G
T
A
D
F
Y
T
E
H
G
V
K
V
T
Site 99
S1406
G
A
G
G
R
R
L
S
S
F
V
T
K
G
Y
Site 100
S1407
A
G
G
R
R
L
S
S
F
V
T
K
G
Y
R
Site 101
T1410
R
R
L
S
S
F
V
T
K
G
Y
R
T
R
R
Site 102
S1423
R
R
L
A
A
D
F
S
V
P
L
I
I
D
I
Site 103
T1480
H
L
R
E
P
G
G
T
H
K
E
D
F
A
S
Site 104
S1487
T
H
K
E
D
F
A
S
G
T
A
A
A
L
A
Site 105
T1544
A
S
S
E
N
A
G
T
L
G
T
V
A
G
S
Site 106
Y1558
S
A
A
G
L
K
L
Y
L
N
E
T
F
S
E
Site 107
T1562
L
K
L
Y
L
N
E
T
F
S
E
L
R
L
D
Site 108
S1564
L
Y
L
N
E
T
F
S
E
L
R
L
D
S
V
Site 109
S1570
F
S
E
L
R
L
D
S
V
V
Q
W
M
E
H
Site 110
T1635
K
A
R
G
L
P
V
T
C
E
V
A
P
H
H
Site 111
S1646
A
P
H
H
L
F
L
S
H
D
D
L
E
R
L
Site 112
S1666
E
V
R
P
E
L
G
S
R
Q
D
V
E
A
L
Site 113
T1691
A
S
D
H
A
P
H
T
L
E
E
K
C
G
S
Site 114
S1698
T
L
E
E
K
C
G
S
R
P
P
P
G
F
P
Site 115
S1724
A
V
S
E
G
R
L
S
L
D
D
L
L
Q
R
Site 116
T1748
H
L
P
P
Q
E
D
T
Y
V
E
V
D
L
E
Site 117
Y1749
L
P
P
Q
E
D
T
Y
V
E
V
D
L
E
H
Site 118
T1772
P
F
S
K
A
H
W
T
P
F
E
G
Q
K
V
Site 119
T1782
E
G
Q
K
V
K
G
T
V
R
R
V
V
L
R
Site 120
Y1794
V
L
R
G
E
V
A
Y
I
D
G
Q
V
L
V
Site 121
Y1805
Q
V
L
V
P
P
G
Y
G
Q
D
V
R
K
W
Site 122
S1823
A
V
P
Q
L
P
P
S
A
P
A
T
S
E
M
Site 123
T1827
L
P
P
S
A
P
A
T
S
E
M
T
T
T
P
Site 124
S1828
P
P
S
A
P
A
T
S
E
M
T
T
T
P
E
Site 125
T1831
A
P
A
T
S
E
M
T
T
T
P
E
R
P
R
Site 126
T1832
P
A
T
S
E
M
T
T
T
P
E
R
P
R
R
Site 127
T1833
A
T
S
E
M
T
T
T
P
E
R
P
R
R
G
Site 128
S1859
P
P
R
I
H
R
A
S
D
P
G
L
P
A
E
Site 129
S1872
A
E
E
P
K
E
K
S
S
R
K
V
A
E
P
Site 130
T1884
A
E
P
E
L
M
G
T
P
D
G
T
C
Y
P
Site 131
T1888
L
M
G
T
P
D
G
T
C
Y
P
P
P
P
V
Site 132
Y1890
G
T
P
D
G
T
C
Y
P
P
P
P
V
P
R
Site 133
S1900
P
P
V
P
R
Q
A
S
P
Q
N
L
G
T
P
Site 134
T1906
A
S
P
Q
N
L
G
T
P
G
L
L
H
P
Q
Site 135
T1914
P
G
L
L
H
P
Q
T
S
P
L
L
H
S
L
Site 136
S1920
Q
T
S
P
L
L
H
S
L
V
G
Q
H
I
L
Site 137
S1928
L
V
G
Q
H
I
L
S
V
Q
Q
F
T
K
D
Site 138
T1933
I
L
S
V
Q
Q
F
T
K
D
Q
M
S
H
L
Site 139
S1938
Q
F
T
K
D
Q
M
S
H
L
F
N
V
A
H
Site 140
S1973
A
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
Site 141
T1974
S
M
F
Y
E
V
S
T
R
T
S
S
S
F
A
Site 142
S1977
Y
E
V
S
T
R
T
S
S
S
F
A
A
A
M
Site 143
S1978
E
V
S
T
R
T
S
S
S
F
A
A
A
M
A
Site 144
S1979
V
S
T
R
T
S
S
S
F
A
A
A
M
A
R
Site 145
S1999
L
S
F
S
E
A
T
S
S
V
Q
K
G
E
S
Site 146
S2000
S
F
S
E
A
T
S
S
V
Q
K
G
E
S
L
Site 147
S2006
S
S
V
Q
K
G
E
S
L
A
D
S
V
Q
T
Site 148
S2010
K
G
E
S
L
A
D
S
V
Q
T
M
S
C
Y
Site 149
S2015
A
D
S
V
Q
T
M
S
C
Y
A
D
V
V
V
Site 150
T2069
T
I
R
E
E
L
G
T
V
N
G
M
T
I
T
Site 151
T2086
G
D
L
K
H
G
R
T
V
H
S
L
A
C
L
Site 152
S2089
K
H
G
R
T
V
H
S
L
A
C
L
L
T
Q
Site 153
Y2103
Q
Y
R
V
S
L
R
Y
V
A
P
P
S
L
R
Site 154
S2121
T
V
R
A
F
V
A
S
R
G
T
K
Q
E
E
Site 155
T2124
A
F
V
A
S
R
G
T
K
Q
E
E
F
E
S
Site 156
S2131
T
K
Q
E
E
F
E
S
I
E
E
A
L
P
D
Site 157
T2139
I
E
E
A
L
P
D
T
D
V
L
Y
M
T
R
Site 158
Y2143
L
P
D
T
D
V
L
Y
M
T
R
I
Q
K
E
Site 159
S2154
I
Q
K
E
R
F
G
S
T
Q
E
Y
E
A
C
Site 160
T2155
Q
K
E
R
F
G
S
T
Q
E
Y
E
A
C
F
Site 161
Y2158
R
F
G
S
T
Q
E
Y
E
A
C
F
G
Q
F
Site 162
S2192
M
P
R
V
N
E
I
S
V
E
V
D
S
D
P
Site 163
S2197
E
I
S
V
E
V
D
S
D
P
R
A
A
Y
F
Site 164
Y2203
D
S
D
P
R
A
A
Y
F
R
Q
A
E
N
G
Site 165
Y2212
R
Q
A
E
N
G
M
Y
I
R
M
A
L
L
A
Site 166
T2220
I
R
M
A
L
L
A
T
V
L
G
R
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation