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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
YWHAQ
Full Name:
14-3-3 protein theta
Alias:
14-3-3 protein tau; 14-3-3 protein T-cell; 1433T; 143T; HS1 protein
Type:
Adapter/scaffold protein, 14-3-3 family
Mass (Da):
27764
Number AA:
245
UniProt ID:
P27348
International Prot ID:
IPI00018146
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005737
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0047485
GO:0019904
GO:0019904
PhosphoSite+
KinaseNET
Biological Process:
GO:0045892
GO:0009892
GO:0010468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
L
A
E
Q
A
E
R
Y
D
D
M
A
T
C
M
Site 2
S37
T
E
Q
G
A
E
L
S
N
E
E
R
N
L
L
Site 3
S45
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Site 4
Y48
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
R
Site 5
S57
N
V
V
G
G
R
R
S
A
W
R
V
I
S
S
Site 6
S63
R
S
A
W
R
V
I
S
S
I
E
Q
K
T
D
Site 7
S64
S
A
W
R
V
I
S
S
I
E
Q
K
T
D
T
Site 8
T71
S
I
E
Q
K
T
D
T
S
D
K
K
L
Q
L
Site 9
S72
I
E
Q
K
T
D
T
S
D
K
K
L
Q
L
I
Site 10
Y82
K
L
Q
L
I
K
D
Y
R
E
K
V
E
S
E
Site 11
S88
D
Y
R
E
K
V
E
S
E
L
R
S
I
C
T
Site 12
S92
K
V
E
S
E
L
R
S
I
C
T
T
V
L
E
Site 13
T95
S
E
L
R
S
I
C
T
T
V
L
E
L
L
D
Site 14
T96
E
L
R
S
I
C
T
T
V
L
E
L
L
D
K
Site 15
T110
K
Y
L
I
A
N
A
T
N
P
E
S
K
V
F
Site 16
S114
A
N
A
T
N
P
E
S
K
V
F
Y
L
K
M
Site 17
Y118
N
P
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Site 18
Y125
Y
L
K
M
K
G
D
Y
F
R
Y
L
A
E
V
Site 19
Y128
M
K
G
D
Y
F
R
Y
L
A
E
V
A
C
G
Site 20
T141
C
G
D
D
R
K
Q
T
I
D
N
S
Q
G
A
Site 21
S145
R
K
Q
T
I
D
N
S
Q
G
A
Y
Q
E
A
Site 22
Y149
I
D
N
S
Q
G
A
Y
Q
E
A
F
D
I
S
Site 23
S156
Y
Q
E
A
F
D
I
S
K
K
E
M
Q
P
T
Site 24
T163
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
Site 25
Y179
L
N
F
S
V
F
Y
Y
E
I
L
N
N
P
E
Site 26
T190
N
N
P
E
L
A
C
T
L
A
K
T
A
F
D
Site 27
T205
E
A
I
A
E
L
D
T
L
N
E
D
S
Y
K
Site 28
S210
L
D
T
L
N
E
D
S
Y
K
D
S
T
L
I
Site 29
Y211
D
T
L
N
E
D
S
Y
K
D
S
T
L
I
M
Site 30
S214
N
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
Site 31
T215
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
Site 32
T226
Q
L
L
R
D
N
L
T
L
W
T
S
D
S
A
Site 33
T229
R
D
N
L
T
L
W
T
S
D
S
A
G
E
E
Site 34
S230
D
N
L
T
L
W
T
S
D
S
A
G
E
E
C
Site 35
S232
L
T
L
W
T
S
D
S
A
G
E
E
C
D
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation