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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VARS
Full Name:
Valyl-tRNA synthetase
Alias:
G7a protein; SYV; Valine tRNA ligase 1, cytoplasmic; Valine-tRNA ligase; ValRS; VARS2
Type:
Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; EC 6.1.1.9; Ligase
Mass (Da):
140476
Number AA:
1264
UniProt ID:
P26640
International Prot ID:
IPI00000873
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004832
PhosphoSite+
KinaseNET
Biological Process:
GO:0006414
GO:0006438
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
T
L
Y
V
S
P
H
P
D
A
F
P
Site 2
Y24
R
A
L
I
A
A
R
Y
G
E
A
G
E
G
P
Site 3
T47
I
C
L
Q
P
P
P
T
S
R
T
P
F
P
P
Site 4
S48
C
L
Q
P
P
P
T
S
R
T
P
F
P
P
P
Site 5
T50
Q
P
P
P
T
S
R
T
P
F
P
P
P
R
L
Site 6
S124
P
A
L
G
L
R
S
S
A
Q
D
P
Q
A
V
Site 7
S140
G
A
L
G
R
A
L
S
P
L
E
E
W
L
R
Site 8
T150
E
E
W
L
R
L
H
T
Y
L
A
G
E
A
P
Site 9
Y151
E
W
L
R
L
H
T
Y
L
A
G
E
A
P
T
Site 10
S217
Y
S
G
A
R
P
L
S
H
Q
P
G
P
E
A
Site 11
T230
E
A
P
A
L
P
K
T
A
A
Q
L
K
K
E
Site 12
T279
K
R
D
P
G
V
I
T
Y
D
L
P
T
P
P
Site 13
Y280
R
D
P
G
V
I
T
Y
D
L
P
T
P
P
G
Site 14
T284
V
I
T
Y
D
L
P
T
P
P
G
E
K
K
D
Site 15
S293
P
G
E
K
K
D
V
S
G
P
M
P
D
S
Y
Site 16
S299
V
S
G
P
M
P
D
S
Y
S
P
R
Y
V
E
Site 17
Y300
S
G
P
M
P
D
S
Y
S
P
R
Y
V
E
A
Site 18
S301
G
P
M
P
D
S
Y
S
P
R
Y
V
E
A
A
Site 19
Y304
P
D
S
Y
S
P
R
Y
V
E
A
A
W
Y
P
Site 20
Y323
Q
G
F
F
K
P
E
Y
G
R
P
N
V
S
A
Site 21
S349
P
P
P
N
V
T
G
S
L
H
L
G
H
A
L
Site 22
S403
L
W
R
E
Q
G
L
S
R
H
Q
L
G
R
E
Site 23
Y428
E
E
K
G
D
R
I
Y
H
Q
L
K
K
L
G
Site 24
S436
H
Q
L
K
K
L
G
S
S
L
D
W
D
R
A
Site 25
S437
Q
L
K
K
L
G
S
S
L
D
W
D
R
A
C
Site 26
Y469
L
H
E
E
G
I
I
Y
R
S
T
R
L
V
N
Site 27
S471
E
E
G
I
I
Y
R
S
T
R
L
V
N
W
S
Site 28
T472
E
G
I
I
Y
R
S
T
R
L
V
N
W
S
C
Site 29
T480
R
L
V
N
W
S
C
T
L
N
S
A
I
S
D
Site 30
T496
E
V
D
K
K
E
L
T
G
R
T
L
L
S
V
Site 31
T499
K
K
E
L
T
G
R
T
L
L
S
V
P
G
Y
Site 32
S502
L
T
G
R
T
L
L
S
V
P
G
Y
K
E
K
Site 33
Y506
T
L
L
S
V
P
G
Y
K
E
K
V
E
F
G
Site 34
S525
F
A
Y
K
V
Q
G
S
D
S
D
E
E
V
V
Site 35
S527
Y
K
V
Q
G
S
D
S
D
E
E
V
V
V
A
Site 36
Y556
V
H
P
K
D
T
R
Y
Q
H
L
K
G
K
N
Site 37
T593
G
T
G
A
V
K
I
T
P
A
H
D
Q
N
D
Site 38
Y601
P
A
H
D
Q
N
D
Y
E
V
G
Q
R
H
G
Site 39
S613
R
H
G
L
E
A
I
S
I
M
D
S
R
G
A
Site 40
Y679
P
L
L
R
P
Q
W
Y
V
R
C
G
E
M
A
Site 41
Y734
W
G
H
R
I
P
A
Y
F
V
T
V
S
D
P
Site 42
T737
R
I
P
A
Y
F
V
T
V
S
D
P
A
V
P
Site 43
Y753
G
E
D
P
D
G
R
Y
W
V
S
G
R
N
E
Site 44
S756
P
D
G
R
Y
W
V
S
G
R
N
E
A
E
A
Site 45
S774
A
A
K
E
F
G
V
S
P
D
K
I
S
L
Q
Site 46
T789
Q
D
E
D
V
L
D
T
W
F
S
S
G
L
F
Site 47
S807
I
L
G
W
P
N
Q
S
E
D
L
S
V
F
Y
Site 48
S811
P
N
Q
S
E
D
L
S
V
F
Y
P
G
T
L
Site 49
Y814
S
E
D
L
S
V
F
Y
P
G
T
L
L
E
T
Site 50
Y850
R
L
P
F
R
E
V
Y
L
H
A
I
V
R
D
Site 51
S864
D
A
H
G
R
K
M
S
K
S
L
G
N
V
I
Site 52
S866
H
G
R
K
M
S
K
S
L
G
N
V
I
D
P
Site 53
Y878
I
D
P
L
D
V
I
Y
G
I
S
L
Q
G
L
Site 54
S881
L
D
V
I
Y
G
I
S
L
Q
G
L
H
N
Q
Site 55
S892
L
H
N
Q
L
L
N
S
N
L
D
P
S
E
V
Site 56
S897
L
N
S
N
L
D
P
S
E
V
E
K
A
K
E
Site 57
S971
L
G
K
G
F
V
P
S
P
T
S
Q
P
G
G
Site 58
T973
K
G
F
V
P
S
P
T
S
Q
P
G
G
H
E
Site 59
S974
G
F
V
P
S
P
T
S
Q
P
G
G
H
E
S
Site 60
S981
S
Q
P
G
G
H
E
S
L
V
D
R
W
I
R
Site 61
T992
R
W
I
R
S
R
L
T
E
A
V
R
L
S
N
Site 62
S998
L
T
E
A
V
R
L
S
N
Q
G
F
Q
A
Y
Site 63
Y1005
S
N
Q
G
F
Q
A
Y
D
F
P
A
V
T
T
Site 64
S1085
R
M
P
Q
A
P
P
S
L
C
V
T
P
Y
P
Site 65
T1089
A
P
P
S
L
C
V
T
P
Y
P
E
P
S
E
Site 66
Y1091
P
S
L
C
V
T
P
Y
P
E
P
S
E
C
S
Site 67
S1095
V
T
P
Y
P
E
P
S
E
C
S
W
K
D
P
Site 68
S1120
S
I
T
R
A
V
R
S
L
R
A
D
Y
N
L
Site 69
Y1125
V
R
S
L
R
A
D
Y
N
L
T
R
I
R
P
Site 70
S1186
A
L
A
S
D
R
C
S
I
H
L
Q
L
Q
G
Site 71
S1225
L
R
E
R
R
A
A
S
G
Y
P
V
K
V
P
Site 72
Y1227
E
R
R
A
A
S
G
Y
P
V
K
V
P
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation