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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
U2AF2
Full Name:
Splicing factor U2AF 65 kDa subunit
Alias:
U2 auxiliary factor 65 kDa subunit
Type:
RNA binding protein
Mass (Da):
53501
Number AA:
475
UniProt ID:
P26368
International Prot ID:
IPI00031556
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
GO:0005681
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0019899
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0000398
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
D
F
D
E
F
E
R
Site 2
S28
E
N
R
H
R
K
R
S
H
S
R
S
R
S
R
Site 3
S30
R
H
R
K
R
S
H
S
R
S
R
S
R
D
R
Site 4
S32
R
K
R
S
H
S
R
S
R
S
R
D
R
K
R
Site 5
S34
R
S
H
S
R
S
R
S
R
D
R
K
R
R
S
Site 6
S41
S
R
D
R
K
R
R
S
R
S
R
D
R
R
N
Site 7
S43
D
R
K
R
R
S
R
S
R
D
R
R
N
R
D
Site 8
S53
R
R
N
R
D
Q
R
S
A
S
R
D
R
R
R
Site 9
S55
N
R
D
Q
R
S
A
S
R
D
R
R
R
R
S
Site 10
S62
S
R
D
R
R
R
R
S
K
P
L
T
R
G
A
Site 11
T66
R
R
R
S
K
P
L
T
R
G
A
K
E
E
H
Site 12
S79
E
H
G
G
L
I
R
S
P
R
H
E
K
K
K
Site 13
Y91
K
K
K
K
V
R
K
Y
W
D
V
P
P
P
G
Site 14
Y107
E
H
I
T
P
M
Q
Y
K
A
M
Q
A
A
G
Site 15
T124
P
A
T
A
L
L
P
T
M
T
P
D
G
L
A
Site 16
S142
T
P
V
P
V
V
G
S
Q
M
T
R
Q
A
R
Site 17
Y152
T
R
Q
A
R
R
L
Y
V
G
N
I
P
F
G
Site 18
T179
Q
M
R
L
G
G
L
T
Q
A
P
G
N
P
V
Site 19
S204
F
A
F
L
E
F
R
S
V
D
E
T
T
Q
A
Site 20
T208
E
F
R
S
V
D
E
T
T
Q
A
M
A
F
D
Site 21
Y232
K
I
R
R
P
H
D
Y
Q
P
L
P
G
M
S
Site 22
S239
Y
Q
P
L
P
G
M
S
E
N
P
S
V
Y
V
Site 23
Y269
F
I
G
G
L
P
N
Y
L
N
D
D
Q
V
K
Site 24
S294
A
F
N
L
V
K
D
S
A
T
G
L
S
K
G
Site 25
Y307
K
G
Y
A
F
C
E
Y
V
D
I
N
V
T
D
Site 26
S336
K
L
L
V
Q
R
A
S
V
G
A
K
N
A
T
Site 27
T343
S
V
G
A
K
N
A
T
L
V
S
P
P
S
T
Site 28
S346
A
K
N
A
T
L
V
S
P
P
S
T
I
N
Q
Site 29
T350
T
L
V
S
P
P
S
T
I
N
Q
T
P
V
T
Site 30
T354
P
P
S
T
I
N
Q
T
P
V
T
L
Q
V
P
Site 31
S366
Q
V
P
G
L
M
S
S
Q
V
Q
M
G
G
H
Site 32
Y395
E
L
L
D
D
E
E
Y
E
E
I
V
E
D
V
Site 33
S407
E
D
V
R
D
E
C
S
K
Y
G
L
V
K
S
Site 34
Y409
V
R
D
E
C
S
K
Y
G
L
V
K
S
I
E
Site 35
S414
S
K
Y
G
L
V
K
S
I
E
I
P
R
P
V
Site 36
T450
Q
K
A
M
Q
G
L
T
G
R
K
F
A
N
R
Site 37
Y463
N
R
V
V
V
T
K
Y
C
D
P
D
S
Y
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation