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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFKBIA
Full Name:
NF-kappa-B inhibitor alpha
Alias:
IkappaBalpha; I-kappa-B-alpha; IKBA; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappaB inhibitor alpha; NFKBI; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; RL/IF-1
Type:
Inhibitor protein
Mass (Da):
35609
Number AA:
317
UniProt ID:
P25963
International Prot ID:
IPI00018330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033256
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051059
GO:0042802
GO:0008139
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0007253
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
L
D
D
R
H
D
S
G
L
D
S
M
K
D
Site 2
S36
R
H
D
S
G
L
D
S
M
K
D
E
E
Y
E
Site 3
Y42
D
S
M
K
D
E
E
Y
E
Q
M
V
K
E
L
Site 4
S63
P
Q
E
V
P
R
G
S
E
P
W
K
Q
Q
L
Site 5
T90
I
H
E
E
K
A
L
T
M
E
V
I
R
Q
V
Site 6
T146
L
R
D
F
R
G
N
T
P
L
H
L
A
C
E
Site 7
Y181
S
I
L
K
A
T
N
Y
N
G
H
T
C
L
H
Site 8
T247
G
A
D
V
N
R
V
T
Y
Q
G
Y
S
P
Y
Site 9
Y248
A
D
V
N
R
V
T
Y
Q
G
Y
S
P
Y
Q
Site 10
Y254
T
Y
Q
G
Y
S
P
Y
Q
L
T
W
G
R
P
Site 11
T257
G
Y
S
P
Y
Q
L
T
W
G
R
P
S
T
R
Site 12
S262
Q
L
T
W
G
R
P
S
T
R
I
Q
Q
Q
L
Site 13
T263
L
T
W
G
R
P
S
T
R
I
Q
Q
Q
L
G
Site 14
T273
Q
Q
Q
L
G
Q
L
T
L
E
N
L
Q
M
L
Site 15
S283
N
L
Q
M
L
P
E
S
E
D
E
E
S
Y
D
Site 16
S288
P
E
S
E
D
E
E
S
Y
D
T
E
S
E
F
Site 17
Y289
E
S
E
D
E
E
S
Y
D
T
E
S
E
F
T
Site 18
T291
E
D
E
E
S
Y
D
T
E
S
E
F
T
E
F
Site 19
S293
E
E
S
Y
D
T
E
S
E
F
T
E
F
T
E
Site 20
T299
E
S
E
F
T
E
F
T
E
D
E
L
P
Y
D
Site 21
Y305
F
T
E
D
E
L
P
Y
D
D
C
V
F
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation