PhosphoNET

           
Protein Info 
   
Short Name:  POLR2A
Full Name:  DNA-directed RNA polymerase II subunit RPB1
Alias:  EC 2.7.7.6; POLR2; POLRA; Polymerase (RNA) II (DNA directed) polypeptide A; RNA pol II largest subunit; RNA polymerase II 220 kd subunit; RPB1
Type:  Transcription initiation complex; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 2.7.7.6; Transferase
Mass (Da):  217176
Number AA:  1970
UniProt ID:  P24928
International Prot ID:  IPI00783837
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005665  GO:0005730   Uniprot OncoNet
Molecular Function:  GO:0003677  GO:0003899  GO:0003968 PhosphoSite+ KinaseNET
Biological Process:  GO:0006368  GO:0000398  GO:0006355 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S8MHGGGPPSGDSACPL
Site 2S11GGPPSGDSACPLRTI
Site 3S27RVQFGVLSPDELKRM
Site 4S35PDELKRMSVTEGGIK
Site 5T37ELKRMSVTEGGIKYP
Site 6Y43VTEGGIKYPETTEGG
Site 7T46GGIKYPETTEGGRPK
Site 8T47GIKYPETTEGGRPKL
Site 9T68RQGVIERTGRCQTCA
Site 10T73ERTGRCQTCAGNMTE
Site 11S121CSKLLVDSNNPKIKD
Site 12S133IKDILAKSKGQPKKR
Site 13T142GQPKKRLTHVYDLCK
Site 14Y145KKRLTHVYDLCKGKN
Site 15T176PEGDEDLTKEKGHGG
Site 16Y187GHGGCGRYQPRIRRS
Site 17S194YQPRIRRSGLELYAE
Site 18Y199RRSGLELYAEWKHVN
Site 19S209WKHVNEDSQEKKILL
Site 20S217QEKKILLSPERVHEI
Site 21S229HEIFKRISDEECFVL
Site 22Y242VLGMEPRYARPEWMI
Site 23S269PAVVMQGSARNQDDL
Site 24T277ARNQDDLTHKLADIV
Site 25S332LPRAMQKSGRPLKSL
Site 26S338KSGRPLKSLKQRLKG
Site 27S362MGKRVDFSARTVITP
Site 28S374ITPDPNLSIDQVGVP
Site 29S411ELVRRGNSQYPGAKY
Site 30Y413VRRGNSQYPGAKYII
Site 31Y418SQYPGAKYIIRDNGD
Site 32T463VIFNRQPTLHKMSMM
Site 33S480RVRILPWSTFRLNLS
Site 34S487STFRLNLSVTTPYNA
Site 35T490RLNLSVTTPYNADFD
Site 36Y492NLSVTTPYNADFDGD
Site 37S508MNLHLPQSLETRAEI
Site 38T527MVPRMIVTPQSNRPV
Site 39S530RMIVTPQSNRPVMGI
Site 40T543GIVQDTLTAVRKFTK
Site 41T549LTAVRKFTKRDVFLE
Site 42T587LKPRPLWTGKQIFSL
Site 43S607INCIRTHSTHPDDED
Site 44S615THPDDEDSGPYKHIS
Site 45Y618DDEDSGPYKHISPGD
Site 46S622SGPYKHISPGDTKVV
Site 47T626KHISPGDTKVVVENG
Site 48S692HTIGIGDSIADSKTY
Site 49S696IGDSIADSKTYQDIQ
Site 50T698DSIADSKTYQDIQNT
Site 51Y699SIADSKTYQDIQNTI
Site 52T728HNNELEPTPGNTLRQ
Site 53T736PGNTLRQTFENQVNR
Site 54T752LNDARDKTGSSAQKS
Site 55S754DARDKTGSSAQKSLS
Site 56S755ARDKTGSSAQKSLSE
Site 57S759TGSSAQKSLSEYNNF
Site 58S761SSAQKSLSEYNNFKS
Site 59Y763AQKSLSEYNNFKSMV
Site 60S768SEYNNFKSMVVSGAK
Site 61S772NFKSMVVSGAKGSKI
Site 62S777VVSGAKGSKINISQV
Site 63T806PFGFKHRTLPHFIKD
Site 64Y815PHFIKDDYGPESRGF
Site 65S819KDDYGPESRGFVENS
Site 66Y827RGFVENSYLAGLTPT
Site 67T850GREGLIDTAVKTAET
Site 68Y859VKTAETGYIQRRLIK
Site 69S867IQRRLIKSMESVMVK
Site 70T878VMVKYDATVRNSINQ
Site 71S882YDATVRNSINQVVQL
Site 72T908VEFQNLATLKPSNKA
Site 73Y924EKKFRFDYTNERALR
Site 74T925KKFRFDYTNERALRR
Site 75T933NERALRRTLQEDLVK
Site 76S944DLVKDVLSNAHIQNE
Site 77S1002HINPRLPSDLHPIKV
Site 78S1030VNGDDPLSRQAQENA
Site 79S1047LFNIHLRSTLCSRRM
Site 80T1048FNIHLRSTLCSRRMA
Site 81S1051HLRSTLCSRRMAEEF
Site 82S1061MAEEFRLSGEAFDWL
Site 83T1100QSLGEPATQMTLNTF
Site 84Y1109MTLNTFHYAGVSAKN
Site 85S1131LKELINISKKPKTPS
Site 86T1136NISKKPKTPSLTVFL
Site 87S1138SKKPKTPSLTVFLLG
Site 88T1140KPKTPSLTVFLLGQS
Site 89T1165LCRLEHTTLRKVTAN
Site 90T1170HTTLRKVTANTAIYY
Site 91Y1176VTANTAIYYDPNPQS
Site 92S1183YYDPNPQSTVVAEDQ
Site 93Y1196DQEWVNVYYEMPDFD
Site 94Y1197QEWVNVYYEMPDFDV
Site 95T1222ELDRKHMTDRKLTME
Site 96T1227HMTDRKLTMEQIAEK
Site 97S1264LRIRIMNSDENKMQE
Site 98T1297SNMLTDMTLQGIEQI
Site 99T1314VYMHLPQTDNKKKII
Site 100T1338LQEWILETDGVSLMR
Site 101T1358DVDPVRTTSNDIVEI
Site 102Y1383KALERELYHVISFDG
Site 103S1387RELYHVISFDGSYVN
Site 104Y1392VISFDGSYVNYRHLA
Site 105T1415RGHLMAITRHGVNRQ
Site 106T1424HGVNRQDTGPLMKCS
Site 107S1431TGPLMKCSFEETVDV
Site 108S1448EAAAHGESDPMKGVS
Site 109Y1482LDAEKCKYGMEIPTN
Site 110T1488KYGMEIPTNIPGLGA
Site 111S1514PSPMGGISPAMTPWN
Site 112T1518GGISPAMTPWNQGAT
Site 113T1525TPWNQGATPAYGAWS
Site 114Y1528NQGATPAYGAWSPSV
Site 115S1532TPAYGAWSPSVGSGM
Site 116S1534AYGAWSPSVGSGMTP
Site 117S1547TPGAAGFSPSAASDA
Site 118S1549GAAGFSPSAASDASG
Site 119S1552GFSPSAASDASGFSP
Site 120S1555PSAASDASGFSPGYS
Site 121S1558ASDASGFSPGYSPAW
Site 122Y1561ASGFSPGYSPAWSPT
Site 123S1562SGFSPGYSPAWSPTP
Site 124S1566PGYSPAWSPTPGSPG
Site 125T1568YSPAWSPTPGSPGSP
Site 126S1571AWSPTPGSPGSPGPS
Site 127S1574PTPGSPGSPGPSSPY
Site 128S1578SPGSPGPSSPYIPSP
Site 129S1579PGSPGPSSPYIPSPG
Site 130Y1581SPGPSSPYIPSPGGA
Site 131S1584PSSPYIPSPGGAMSP
Site 132S1590PSPGGAMSPSYSPTS
Site 133S1592PGGAMSPSYSPTSPA
Site 134Y1593GGAMSPSYSPTSPAY
Site 135S1594GAMSPSYSPTSPAYE
Site 136T1596MSPSYSPTSPAYEPR
Site 137S1597SPSYSPTSPAYEPRS
Site 138Y1600YSPTSPAYEPRSPGG
Site 139S1604SPAYEPRSPGGYTPQ
Site 140Y1608EPRSPGGYTPQSPSY
Site 141T1609PRSPGGYTPQSPSYS
Site 142S1612PGGYTPQSPSYSPTS
Site 143S1614GYTPQSPSYSPTSPS
Site 144Y1615YTPQSPSYSPTSPSY
Site 145S1616TPQSPSYSPTSPSYS
Site 146T1618QSPSYSPTSPSYSPT
Site 147S1619SPSYSPTSPSYSPTS
Site 148S1621SYSPTSPSYSPTSPS
Site 149Y1622YSPTSPSYSPTSPSY
Site 150S1623SPTSPSYSPTSPSYS
Site 151T1625TSPSYSPTSPSYSPT
Site 152S1628SYSPTSPSYSPTSPN
Site 153Y1629YSPTSPSYSPTSPNY
Site 154S1630SPTSPSYSPTSPNYS
Site 155T1632TSPSYSPTSPNYSPT
Site 156S1633SPSYSPTSPNYSPTS
Site 157Y1636YSPTSPNYSPTSPSY
Site 158S1637SPTSPNYSPTSPSYS
Site 159T1639TSPNYSPTSPSYSPT
Site 160S1640SPNYSPTSPSYSPTS
Site 161S1642NYSPTSPSYSPTSPS
Site 162Y1748YSPTSPNYSPTSPNY
Site 163S1749SPTSPNYSPTSPNYT
Site 164S1752SPNYSPTSPNYTPTS
Site 165Y1755YSPTSPNYTPTSPSY
Site 166T1756SPTSPNYTPTSPSYS
Site 167T1758TSPNYTPTSPSYSPT
Site 168S1759SPNYTPTSPSYSPTS
Site 169S1761NYTPTSPSYSPTSPS
Site 170Y1762YTPTSPSYSPTSPSY
Site 171S1763TPTSPSYSPTSPSYS
Site 172S1770SPTSPSYSPTSPNYT
Site 173T1772TSPSYSPTSPNYTPT
Site 174S1773SPSYSPTSPNYTPTS
Site 175Y1776YSPTSPNYTPTSPNY
Site 176T1777SPTSPNYTPTSPNYS
Site 177S1780SPNYTPTSPNYSPTS
Site 178Y1783YTPTSPNYSPTSPSY
Site 179S1784TPTSPNYSPTSPSYS
Site 180T1800TSPSYSPTSPSYSPS
Site 181S1801SPSYSPTSPSYSPSS
Site 182S1803SYSPTSPSYSPSSPR
Site 183Y1804YSPTSPSYSPSSPRY
Site 184S1805SPTSPSYSPSSPRYT
Site 185S1807TSPSYSPSSPRYTPQ
Site 186S1808SPSYSPSSPRYTPQS
Site 187Y1811YSPSSPRYTPQSPTY
Site 188T1812SPSSPRYTPQSPTYT
Site 189S1815SPRYTPQSPTYTPSS
Site 190T1817RYTPQSPTYTPSSPS
Site 191Y1818YTPQSPTYTPSSPSY
Site 192T1819TPQSPTYTPSSPSYS
Site 193S1821QSPTYTPSSPSYSPS
Site 194S1822SPTYTPSSPSYSPSS
Site 195S1824TYTPSSPSYSPSSPS
Site 196Y1825YTPSSPSYSPSSPSY
Site 197S1826TPSSPSYSPSSPSYS
Site 198S1828SSPSYSPSSPSYSPT
Site 199S1829SPSYSPSSPSYSPTS
Site 200S1831SYSPSSPSYSPTSPK
Site 201Y1832YSPSSPSYSPTSPKY
Site 202S1833SPSSPSYSPTSPKYT
Site 203T1835SSPSYSPTSPKYTPT
Site 204S1836SPSYSPTSPKYTPTS
Site 205Y1839YSPTSPKYTPTSPSY
Site 206T1840SPTSPKYTPTSPSYS
Site 207T1842TSPKYTPTSPSYSPS
Site 208S1843SPKYTPTSPSYSPSS
Site 209S1845KYTPTSPSYSPSSPE
Site 210Y1846YTPTSPSYSPSSPEY
Site 211S1847TPTSPSYSPSSPEYT
Site 212S1849TSPSYSPSSPEYTPT
Site 213S1850SPSYSPSSPEYTPTS
Site 214Y1853YSPSSPEYTPTSPKY
Site 215T1854SPSSPEYTPTSPKYS
Site 216T1856SSPEYTPTSPKYSPT
Site 217S1857SPEYTPTSPKYSPTS
Site 218Y1860YTPTSPKYSPTSPKY
Site 219S1861TPTSPKYSPTSPKYS
Site 220T1863TSPKYSPTSPKYSPT
Site 221S1864SPKYSPTSPKYSPTS
Site 222Y1867YSPTSPKYSPTSPKY
Site 223S1868SPTSPKYSPTSPKYS
Site 224Y1874YSPTSPKYSPTSPTY
Site 225S1875SPTSPKYSPTSPTYS
Site 226T1877TSPKYSPTSPTYSPT
Site 227S1878SPKYSPTSPTYSPTT
Site 228T1880KYSPTSPTYSPTTPK
Site 229Y1881YSPTSPTYSPTTPKY
Site 230S1882SPTSPTYSPTTPKYS
Site 231T1884TSPTYSPTTPKYSPT
Site 232T1885SPTYSPTTPKYSPTS
Site 233Y1888YSPTTPKYSPTSPTY
Site 234S1889SPTTPKYSPTSPTYS
Site 235T1891TTPKYSPTSPTYSPT
Site 236S1892TPKYSPTSPTYSPTS
Site 237T1894KYSPTSPTYSPTSPV
Site 238Y1895YSPTSPTYSPTSPVY
Site 239S1896SPTSPTYSPTSPVYT
Site 240T1898TSPTYSPTSPVYTPT
Site 241S1899SPTYSPTSPVYTPTS
Site 242Y1902YSPTSPVYTPTSPKY
Site 243T1903SPTSPVYTPTSPKYS
Site 244T1905TSPVYTPTSPKYSPT
Site 245S1906SPVYTPTSPKYSPTS
Site 246Y1909YTPTSPKYSPTSPTY
Site 247S1910TPTSPKYSPTSPTYS
Site 248S1913SPKYSPTSPTYSPTS
Site 249T1915KYSPTSPTYSPTSPK
Site 250Y1916YSPTSPTYSPTSPKY
Site 251S1917SPTSPTYSPTSPKYS
Site 252T1919TSPTYSPTSPKYSPT
Site 253S1920SPTYSPTSPKYSPTS
Site 254Y1930YSPTSPTYSPTSPKG
Site 255S1931SPTSPTYSPTSPKGS
Site 256T1933TSPTYSPTSPKGSTY
Site 257S1934SPTYSPTSPKGSTYS
Site 258S1938SPTSPKGSTYSPTSP
Site 259T1939PTSPKGSTYSPTSPG
Site 260Y1940TSPKGSTYSPTSPGY
Site 261S1941SPKGSTYSPTSPGYS
Site 262T1943KGSTYSPTSPGYSPT
Site 263S1944GSTYSPTSPGYSPTS
Site 264Y1947YSPTSPGYSPTSPTY
Site 265S1948SPTSPGYSPTSPTYS
Site 266T1950TSPGYSPTSPTYSLT
Site 267S1951SPGYSPTSPTYSLTS
Site 268Y1954YSPTSPTYSLTSPAI
Site 269S1955SPTSPTYSLTSPAIS
Site 270T1957TSPTYSLTSPAISPD
Site 271S1958SPTYSLTSPAISPDD
Site 272S1962SLTSPAISPDDSDEE
Site 273S1966PAISPDDSDEEN___
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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