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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cyclin E1
Full Name:
G1/S-specific cyclin-E1
Alias:
CCNE; CCNE1
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
47077
Number AA:
410
UniProt ID:
P24864
International Prot ID:
IPI00031077
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0030521
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
R
D
A
K
E
R
D
T
M
K
E
D
G
G
A
Site 2
S25
E
D
G
G
A
E
F
S
A
R
S
R
K
R
K
Site 3
T36
R
K
R
K
A
N
V
T
V
F
L
Q
D
P
D
Site 4
T52
E
M
A
K
I
D
R
T
A
R
D
Q
C
G
S
Site 5
S59
T
A
R
D
Q
C
G
S
Q
P
W
D
N
N
A
Site 6
S73
A
V
C
A
D
P
C
S
L
I
P
T
P
D
K
Site 7
T77
D
P
C
S
L
I
P
T
P
D
K
E
D
D
D
Site 8
Y87
K
E
D
D
D
R
V
Y
P
N
S
T
C
K
P
Site 9
S90
D
D
R
V
Y
P
N
S
T
C
K
P
R
I
I
Site 10
S100
K
P
R
I
I
A
P
S
R
G
S
P
L
P
V
Site 11
S103
I
I
A
P
S
R
G
S
P
L
P
V
L
S
W
Site 12
S109
G
S
P
L
P
V
L
S
W
A
N
R
E
E
V
Site 13
T126
I
M
L
N
K
E
K
T
Y
L
R
D
Q
H
F
Site 14
Y127
M
L
N
K
E
K
T
Y
L
R
D
Q
H
F
L
Site 15
T165
V
Y
K
L
H
R
E
T
F
Y
L
A
Q
D
F
Site 16
Y167
K
L
H
R
E
T
F
Y
L
A
Q
D
F
F
D
Site 17
Y176
A
Q
D
F
F
D
R
Y
M
A
T
Q
E
N
V
Site 18
Y206
A
A
K
L
E
E
I
Y
P
P
K
L
H
Q
F
Site 19
Y215
P
K
L
H
Q
F
A
Y
V
T
D
G
A
C
S
Site 20
Y270
H
E
V
L
L
P
Q
Y
P
Q
Q
I
F
I
Q
Site 21
S308
A
S
A
L
Y
H
F
S
S
S
E
L
M
Q
K
Site 22
S309
S
A
L
Y
H
F
S
S
S
E
L
M
Q
K
V
Site 23
S310
A
L
Y
H
F
S
S
S
E
L
M
Q
K
V
S
Site 24
T341
F
A
M
V
I
R
E
T
G
S
S
K
L
K
H
Site 25
S344
V
I
R
E
T
G
S
S
K
L
K
H
F
R
G
Site 26
T362
E
D
A
H
N
I
Q
T
H
R
D
S
L
D
L
Site 27
S366
N
I
Q
T
H
R
D
S
L
D
L
L
D
K
A
Site 28
S381
R
A
K
K
A
M
L
S
E
Q
N
R
A
S
P
Site 29
S387
L
S
E
Q
N
R
A
S
P
L
P
S
G
L
L
Site 30
S391
N
R
A
S
P
L
P
S
G
L
L
T
P
P
Q
Site 31
T395
P
L
P
S
G
L
L
T
P
P
Q
S
G
K
K
Site 32
S399
G
L
L
T
P
P
Q
S
G
K
K
Q
S
S
G
Site 33
S404
P
Q
S
G
K
K
Q
S
S
G
P
E
M
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation