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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGK-A
Full Name:
Diacylglycerol kinase alpha
Alias:
80 kDa diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK- alpha; DGKA; DGK-alpha; Diacylglycerol kinase, alpha; Diacylglycerol kinase, alpha 80kDa; Diglyceride kinase
Type:
Kinase, lipid; Lipid Metabolism - glycerophospholipid; EC 2.7.1.107; Lipid Metabolism - glycerolipid
Mass (Da):
82630
Number AA:
735
UniProt ID:
P23743
International Prot ID:
IPI00333143
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0004143
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
K
E
R
G
L
I
S
P
S
D
F
A
Q
L
Site 2
S11
E
R
G
L
I
S
P
S
D
F
A
Q
L
Q
K
Site 3
Y19
D
F
A
Q
L
Q
K
Y
M
E
Y
S
T
K
K
Site 4
Y22
Q
L
Q
K
Y
M
E
Y
S
T
K
K
V
S
D
Site 5
S23
L
Q
K
Y
M
E
Y
S
T
K
K
V
S
D
V
Site 6
T24
Q
K
Y
M
E
Y
S
T
K
K
V
S
D
V
L
Site 7
S28
E
Y
S
T
K
K
V
S
D
V
L
K
L
F
E
Site 8
Y42
E
D
G
E
M
A
K
Y
V
Q
G
D
A
I
G
Site 9
Y50
V
Q
G
D
A
I
G
Y
E
G
F
Q
Q
F
L
Site 10
S71
D
N
V
P
R
H
L
S
L
A
L
F
Q
S
F
Site 11
S104
N
D
V
S
C
Y
F
S
L
L
E
G
G
R
P
Site 12
T118
P
E
D
K
L
E
F
T
F
K
L
Y
D
T
D
Site 13
Y122
L
E
F
T
F
K
L
Y
D
T
D
R
N
G
I
Site 14
T124
F
T
F
K
L
Y
D
T
D
R
N
G
I
L
D
Site 15
S132
D
R
N
G
I
L
D
S
S
E
V
D
K
I
I
Site 16
S133
R
N
G
I
L
D
S
S
E
V
D
K
I
I
L
Site 17
S154
E
Y
L
D
W
D
V
S
E
L
R
P
I
L
Q
Site 18
Y169
E
M
M
K
E
I
D
Y
D
G
S
G
S
V
S
Site 19
S172
K
E
I
D
Y
D
G
S
G
S
V
S
Q
A
E
Site 20
S174
I
D
Y
D
G
S
G
S
V
S
Q
A
E
W
V
Site 21
S176
Y
D
G
S
G
S
V
S
Q
A
E
W
V
R
A
Site 22
T199
V
L
L
G
L
E
M
T
L
K
D
D
G
Q
H
Site 23
Y218
K
R
F
P
R
P
V
Y
C
N
L
C
E
S
S
Site 24
S234
G
L
G
K
Q
G
L
S
C
N
L
C
K
Y
T
Site 25
S256
K
A
L
P
C
E
V
S
T
Y
A
K
S
R
K
Site 26
T257
A
L
P
C
E
V
S
T
Y
A
K
S
R
K
D
Site 27
Y258
L
P
C
E
V
S
T
Y
A
K
S
R
K
D
I
Site 28
S269
R
K
D
I
G
V
Q
S
H
V
W
V
R
G
G
Site 29
Y292
C
Q
K
K
I
R
I
Y
H
S
L
T
G
L
H
Site 30
S332
R
D
H
I
L
P
P
S
S
I
Y
P
S
V
L
Site 31
Y335
I
L
P
P
S
S
I
Y
P
S
V
L
A
S
G
Site 32
S337
P
P
S
S
I
Y
P
S
V
L
A
S
G
P
D
Site 33
S341
I
Y
P
S
V
L
A
S
G
P
D
R
K
N
S
Site 34
S348
S
G
P
D
R
K
N
S
K
T
S
Q
K
T
M
Site 35
T350
P
D
R
K
N
S
K
T
S
Q
K
T
M
D
D
Site 36
S361
T
M
D
D
L
N
L
S
T
S
E
A
L
R
I
Site 37
S363
D
D
L
N
L
S
T
S
E
A
L
R
I
D
P
Site 38
S385
L
V
F
V
N
P
K
S
G
G
K
Q
G
Q
R
Site 39
Y399
R
V
L
W
K
F
Q
Y
I
L
N
P
R
Q
V
Site 40
Y477
C
L
R
W
G
G
G
Y
E
G
Q
N
L
A
K
Site 41
S513
P
Q
Q
T
E
E
K
S
D
P
V
P
F
Q
I
Site 42
Y524
P
F
Q
I
I
N
N
Y
F
S
I
G
V
D
A
Site 43
Y544
F
H
I
M
R
E
K
Y
P
E
K
F
N
S
R
Site 44
Y558
R
M
K
N
K
L
W
Y
F
E
F
A
T
S
E
Site 45
S569
A
T
S
E
S
I
F
S
T
C
K
K
L
E
E
Site 46
T570
T
S
E
S
I
F
S
T
C
K
K
L
E
E
S
Site 47
S577
T
C
K
K
L
E
E
S
L
T
V
E
I
C
G
Site 48
T579
K
K
L
E
E
S
L
T
V
E
I
C
G
K
P
Site 49
T615
G
S
N
L
W
G
D
T
R
R
P
H
G
D
I
Site 50
Y623
R
R
P
H
G
D
I
Y
G
I
N
Q
A
L
G
Site 51
T637
G
A
T
A
K
V
I
T
D
P
D
I
L
K
T
Site 52
T644
T
D
P
D
I
L
K
T
C
V
P
D
L
S
D
Site 53
S650
K
T
C
V
P
D
L
S
D
K
R
L
E
V
V
Site 54
Y669
A
I
E
M
G
Q
I
Y
T
K
L
K
N
A
G
Site 55
S683
G
R
R
L
A
K
C
S
E
I
T
F
H
T
T
Site 56
T728
M
G
P
P
P
R
S
T
N
F
F
G
F
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation