KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ATP2B4
Full Name:
Plasma membrane calcium-transporting ATPase 4
Alias:
AT2B4; ATB4; ATP2B2; ATPase, Ca++ transporting, plasma membrane 4; Matrix-remodeling-associated protein 1; MXRA1; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4
Type:
Membrane protein, integral; Channel, calcium; Hydrolase; EC 3.6.3.8; Transporter
Mass (Da):
137920
Number AA:
1241
UniProt ID:
P23634
International Prot ID:
IPI00217165
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0005388
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0006816
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
R
V
L
P
A
N
S
M
A
E
S
R
E
G
Site 2
S17
P
A
N
S
M
A
E
S
R
E
G
D
F
G
C
Site 3
S37
R
K
L
M
E
L
R
S
R
D
A
L
T
Q
I
Site 4
T42
L
R
S
R
D
A
L
T
Q
I
N
V
H
Y
G
Site 5
S56
G
G
V
Q
N
L
C
S
R
L
K
T
S
P
V
Site 6
T60
N
L
C
S
R
L
K
T
S
P
V
E
G
L
S
Site 7
S61
L
C
S
R
L
K
T
S
P
V
E
G
L
S
G
Site 8
S67
T
S
P
V
E
G
L
S
G
N
P
A
D
L
E
Site 9
T92
I
P
P
K
K
P
K
T
F
L
E
L
V
W
E
Site 10
Y122
I
S
L
V
L
S
F
Y
R
P
A
G
E
E
N
Site 11
T138
L
C
G
Q
V
A
T
T
P
E
D
E
N
E
A
Site 12
S191
I
E
Q
E
Q
K
F
S
I
I
R
N
G
Q
L
Site 13
Y216
G
D
I
A
Q
V
K
Y
G
D
L
L
P
A
D
Site 14
S237
N
D
L
K
I
D
E
S
S
L
T
G
E
S
D
Site 15
S238
D
L
K
I
D
E
S
S
L
T
G
E
S
D
H
Site 16
T240
K
I
D
E
S
S
L
T
G
E
S
D
H
V
K
Site 17
S243
E
S
S
L
T
G
E
S
D
H
V
K
K
S
L
Site 18
S249
E
S
D
H
V
K
K
S
L
D
K
D
P
M
L
Site 19
S258
D
K
D
P
M
L
L
S
G
T
H
V
M
E
G
Site 20
T260
D
P
M
L
L
S
G
T
H
V
M
E
G
S
G
Site 21
T315
E
N
R
N
K
A
K
T
Q
D
G
V
A
L
E
Site 22
S328
L
E
I
Q
P
L
N
S
Q
E
G
I
D
N
E
Site 23
S350
K
V
P
K
K
E
K
S
V
L
Q
G
K
L
T
Site 24
T415
K
F
F
I
I
G
I
T
V
L
V
V
A
V
P
Site 25
Y435
A
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
Site 26
S436
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
D
Site 27
T467
T
A
I
C
S
D
K
T
G
T
L
T
M
N
R
Site 28
T471
S
D
K
T
G
T
L
T
M
N
R
M
T
V
V
Site 29
S492
I
H
Y
R
Q
I
P
S
P
D
V
F
L
P
K
Site 30
S516
S
I
N
S
A
Y
T
S
K
I
L
P
P
E
K
Site 31
T535
P
R
Q
V
G
N
K
T
E
C
A
L
L
G
F
Site 32
Y550
V
T
D
L
K
Q
D
Y
Q
A
V
R
N
E
V
Site 33
Y563
E
V
P
E
E
K
L
Y
K
V
Y
T
F
N
S
Site 34
Y566
E
E
K
L
Y
K
V
Y
T
F
N
S
V
R
K
Site 35
T567
E
K
L
Y
K
V
Y
T
F
N
S
V
R
K
S
Site 36
S570
Y
K
V
Y
T
F
N
S
V
R
K
S
M
S
T
Site 37
S574
T
F
N
S
V
R
K
S
M
S
T
V
I
R
N
Site 38
T577
S
V
R
K
S
M
S
T
V
I
R
N
P
N
G
Site 39
Y589
P
N
G
G
F
R
M
Y
S
K
G
A
S
E
I
Site 40
S590
N
G
G
F
R
M
Y
S
K
G
A
S
E
I
I
Site 41
S594
R
M
Y
S
K
G
A
S
E
I
I
L
R
K
C
Site 42
T648
A
Y
R
D
F
D
D
T
E
P
S
W
D
N
E
Site 43
S651
D
F
D
D
T
E
P
S
W
D
N
E
N
E
I
Site 44
T691
K
C
K
Q
A
G
I
T
V
R
M
V
T
G
D
Site 45
S756
K
L
R
V
L
A
R
S
S
P
T
D
K
H
T
Site 46
S757
L
R
V
L
A
R
S
S
P
T
D
K
H
T
L
Site 47
T763
S
S
P
T
D
K
H
T
L
V
K
G
I
I
D
Site 48
S771
L
V
K
G
I
I
D
S
T
V
G
E
H
R
Q
Site 49
T772
V
K
G
I
I
D
S
T
V
G
E
H
R
Q
V
Site 50
T819
E
A
S
D
I
I
L
T
D
D
N
F
T
S
I
Site 51
Y837
V
M
W
G
R
N
V
Y
D
S
I
S
K
F
L
Site 52
S841
R
N
V
Y
D
S
I
S
K
F
L
Q
F
Q
L
Site 53
S898
A
T
E
P
P
T
E
S
L
L
K
R
R
P
Y
Site 54
Y905
S
L
L
K
R
R
P
Y
G
R
N
K
P
L
I
Site 55
S946
E
K
F
F
D
I
D
S
G
R
K
A
P
L
H
Site 56
S954
G
R
K
A
P
L
H
S
P
P
S
Q
H
Y
T
Site 57
S957
A
P
L
H
S
P
P
S
Q
H
Y
T
I
V
F
Site 58
Y960
H
S
P
P
S
Q
H
Y
T
I
V
F
N
T
F
Site 59
T961
S
P
P
S
Q
H
Y
T
I
V
F
N
T
F
V
Site 60
S1020
E
F
G
G
K
P
F
S
C
T
S
L
S
L
S
Site 61
T1022
G
G
K
P
F
S
C
T
S
L
S
L
S
Q
W
Site 62
S1023
G
K
P
F
S
C
T
S
L
S
L
S
Q
W
L
Site 63
T1102
R
G
L
N
R
I
Q
T
Q
I
D
V
I
N
T
Site 64
S1115
N
T
F
Q
T
G
A
S
F
K
G
V
L
R
R
Site 65
S1148
K
V
V
K
A
F
H
S
S
L
H
E
S
I
Q
Site 66
S1149
V
V
K
A
F
H
S
S
L
H
E
S
I
Q
K
Site 67
S1153
F
H
S
S
L
H
E
S
I
Q
K
P
Y
N
Q
Site 68
Y1158
H
E
S
I
Q
K
P
Y
N
Q
K
S
I
H
S
Site 69
S1162
Q
K
P
Y
N
Q
K
S
I
H
S
F
M
T
H
Site 70
S1165
Y
N
Q
K
S
I
H
S
F
M
T
H
P
E
F
Site 71
T1168
K
S
I
H
S
F
M
T
H
P
E
F
A
I
E
Site 72
T1181
I
E
E
E
L
P
R
T
P
L
L
D
E
E
E
Site 73
T1200
D
K
A
S
K
F
G
T
R
V
L
L
L
D
G
Site 74
T1210
L
L
L
D
G
E
V
T
P
Y
A
N
T
N
N
Site 75
Y1212
L
D
G
E
V
T
P
Y
A
N
T
N
N
N
A
Site 76
S1230
N
Q
V
Q
L
P
Q
S
D
S
S
L
Q
S
L
Site 77
S1232
V
Q
L
P
Q
S
D
S
S
L
Q
S
L
E
T
Site 78
S1233
Q
L
P
Q
S
D
S
S
L
Q
S
L
E
T
S
Site 79
S1236
Q
S
D
S
S
L
Q
S
L
E
T
S
V
_
_
Site 80
S1240
S
L
Q
S
L
E
T
S
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation