PhosphoNET

           
Protein Info 
   
Short Name:  eIF4B
Full Name:  Eukaryotic translation initiation factor 4B
Alias:  EIF-4B; IF4B
Type:  Protein synthesis protein
Mass (Da):  69151
Number AA:  611
UniProt ID:  P23588
International Prot ID:  IPI00012079
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0016281   Uniprot OncoNet
Molecular Function:  GO:0003723  GO:0000166  GO:0003743 PhosphoSite+ KinaseNET
Biological Process:  GO:0006446  GO:0006412   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T14KKNKKGKTISLTDFL
Site 2S16NKKGKTISLTDFLAE
Site 3T18KGKTISLTDFLAEDG
Site 4T27FLAEDGGTGGGSTYV
Site 5S31DGGTGGGSTYVSKPV
Site 6T32GGTGGGSTYVSKPVS
Site 7Y33GTGGGSTYVSKPVSW
Site 8S35GGGSTYVSKPVSWAD
Site 9S39TYVSKPVSWADETDD
Site 10T44PVSWADETDDLEGDV
Site 11S52DDLEGDVSTTWHSND
Site 12T53DLEGDVSTTWHSNDD
Site 13S57DVSTTWHSNDDDVYR
Site 14Y63HSNDDDVYRAPPIDR
Site 15S71RAPPIDRSILPTAPR
Site 16T75IDRSILPTAPRAARE
Site 17S88REPNIDRSRLPKSPP
Site 18S93DRSRLPKSPPYTAFL
Site 19Y96RLPKSPPYTAFLGNL
Site 20T97LPKSPPYTAFLGNLP
Site 21Y105AFLGNLPYDVTEESI
Site 22T108GNLPYDVTEESIKEF
Site 23S111PYDVTEESIKEFFRG
Site 24S122FFRGLNISAVRLPRE
Site 25S131VRLPREPSNPERLKG
Site 26Y141ERLKGFGYAEFEDLD
Site 27S152EDLDSLLSALSLNEE
Site 28S155DSLLSALSLNEESLG
Site 29S183DKDRDDRSFGRDRNR
Site 30S192GRDRNRDSDKTDTDW
Site 31T195RNRDSDKTDTDWRAR
Site 32T197RDSDKTDTDWRARPA
Site 33T205DWRARPATDSFDDYP
Site 34S207RARPATDSFDDYPPR
Site 35Y211ATDSFDDYPPRRGDD
Site 36S219PPRRGDDSFGDKYRD
Site 37Y224DDSFGDKYRDRYDSD
Site 38Y228GDKYRDRYDSDRYRD
Site 39S230KYRDRYDSDRYRDGY
Site 40Y233DRYDSDRYRDGYRDG
Site 41Y237SDRYRDGYRDGYRDG
Site 42Y241RDGYRDGYRDGPRRD
Site 43Y252PRRDMDRYGGRDRYD
Site 44Y258RYGGRDRYDDRGSRD
Site 45S263DRYDDRGSRDYDRGY
Site 46Y266DDRGSRDYDRGYDSR
Site 47Y270SRDYDRGYDSRIGSG
Site 48S272DYDRGYDSRIGSGRR
Site 49S276GYDSRIGSGRRAFGS
Site 50S283SGRRAFGSGYRRDDD
Site 51Y285RRAFGSGYRRDDDYR
Site 52Y291GYRRDDDYRGGGDRY
Site 53Y298YRGGGDRYEDRYDRR
Site 54Y302GDRYEDRYDRRDDRS
Site 55S309YDRRDDRSWSSRDDY
Site 56S311RRDDRSWSSRDDYSR
Site 57S312RDDRSWSSRDDYSRD
Site 58Y316SWSSRDDYSRDDYRR
Site 59S317WSSRDDYSRDDYRRD
Site 60Y321DDYSRDDYRRDDRGP
Site 61S340KLNLKPRSTPKEDDS
Site 62T341LNLKPRSTPKEDDSS
Site 63S347STPKEDDSSASTSQS
Site 64S348TPKEDDSSASTSQST
Site 65S350KEDDSSASTSQSTRA
Site 66T351EDDSSASTSQSTRAA
Site 67S352DDSSASTSQSTRAAS
Site 68S354SSASTSQSTRAASIF
Site 69S359SQSTRAASIFGGAKP
Site 70T369GGAKPVDTAAREREV
Site 71S406RPRERHPSWRSEETQ
Site 72S409ERHPSWRSEETQERE
Site 73T412PSWRSEETQERERSR
Site 74S418ETQERERSRTGSESS
Site 75T420QERERSRTGSESSQT
Site 76S422RERSRTGSESSQTGT
Site 77S424RSRTGSESSQTGTST
Site 78S425SRTGSESSQTGTSTT
Site 79T427TGSESSQTGTSTTSS
Site 80T429SESSQTGTSTTSSRN
Site 81S430ESSQTGTSTTSSRNA
Site 82T431SSQTGTSTTSSRNAR
Site 83T432SQTGTSTTSSRNARR
Site 84S433QTGTSTTSSRNARRR
Site 85S434TGTSTTSSRNARRRE
Site 86S442RNARRRESEKSLENE
Site 87S445RRRESEKSLENETLN
Site 88T450EKSLENETLNKEEDC
Site 89S459NKEEDCHSPTSKPPK
Site 90T461EEDCHSPTSKPPKPD
Site 91S462EDCHSPTSKPPKPDQ
Site 92S488ENAWVKRSSNPPARS
Site 93S489NAWVKRSSNPPARSQ
Site 94S495SSNPPARSQSSDTEQ
Site 95S497NPPARSQSSDTEQQS
Site 96S498PPARSQSSDTEQQSP
Site 97T500ARSQSSDTEQQSPTS
Site 98S504SSDTEQQSPTSGGGK
Site 99T506DTEQQSPTSGGGKVA
Site 100S507TEQQSPTSGGGKVAP
Site 101S518KVAPAQPSEEGPGRK
Site 102S543PKGQTGNSSRGPGDG
Site 103S544KGQTGNSSRGPGDGG
Site 104S559NRDHWKESDRKDGKK
Site 105S570DGKKDQDSRSAPEPK
Site 106S572KKDQDSRSAPEPKKP
Site 107S585KPEENPASKFSSASK
Site 108S589NPASKFSSASKYAAL
Site 109S591ASKFSSASKYAALSV
Site 110Y593KFSSASKYAALSVDG
Site 111S597ASKYAALSVDGEDEN
Site 112Y609DENEGEDYAE_____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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