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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cbl
Full Name:
E3 ubiquitin-protein ligase CBL
Alias:
Cas-Br-M (murine) ecotropic retroviral transforming; Cas-Br-M (murine) ecotropic retroviral transforming sequence; CBL E3 ubiquitin protein ligase; CBL2; Oncogene CBL2; Proto-oncogene c-CBL; RNF55; Signal transduction protein CBL
Type:
Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Adaptor/scaffold
Mass (Da):
99633
Number AA:
906
UniProt ID:
P22681
International Prot ID:
IPI00027269
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0005509
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007173
GO:0019941
GO:0048260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
G
N
V
K
K
S
S
G
A
G
G
G
S
Site 2
S9
A
G
N
V
K
K
S
S
G
A
G
G
G
S
G
Site 3
S15
S
S
G
A
G
G
G
S
G
S
G
G
S
G
S
Site 4
S17
G
A
G
G
G
S
G
S
G
G
S
G
S
G
G
Site 5
S20
G
G
S
G
S
G
G
S
G
S
G
G
L
I
G
Site 6
T50
L
S
P
H
P
P
G
T
V
D
K
K
M
V
E
Site 7
S80
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
Site 8
Y83
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
Site 9
Y92
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
Site 10
S100
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
Site 11
Y102
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
Site 12
Y114
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
Site 13
T126
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
Site 14
S131
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
Site 15
Y141
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
Site 16
S145
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
Site 17
T152
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
Site 18
T178
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
Site 19
T182
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
Site 20
T198
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
Site 21
S204
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
Site 22
S253
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
Site 23
S260
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Site 24
T273
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
Site 25
Y337
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Site 26
T350
R
N
Q
N
P
D
L
T
G
L
C
E
P
T
P
Site 27
T356
L
T
G
L
C
E
P
T
P
Q
D
H
I
K
V
Site 28
Y368
I
K
V
T
Q
E
Q
Y
E
L
Y
C
E
M
G
Site 29
Y371
T
Q
E
Q
Y
E
L
Y
C
E
M
G
S
T
F
Site 30
S439
D
P
F
D
P
R
G
S
G
S
L
L
R
Q
G
Site 31
S441
F
D
P
R
G
S
G
S
L
L
R
Q
G
A
E
Site 32
S452
Q
G
A
E
G
A
P
S
P
N
Y
D
D
D
D
Site 33
Y455
E
G
A
P
S
P
N
Y
D
D
D
D
D
E
R
Site 34
T466
D
D
E
R
A
D
D
T
L
F
M
M
K
E
L
Site 35
S483
A
K
V
E
R
P
P
S
P
F
S
M
A
P
Q
Site 36
S486
E
R
P
P
S
P
F
S
M
A
P
Q
A
S
L
Site 37
S492
F
S
M
A
P
Q
A
S
L
P
P
V
P
P
R
Site 38
T518
S
S
A
S
A
L
G
T
A
S
K
A
A
S
G
Site 39
S524
G
T
A
S
K
A
A
S
G
S
L
H
K
D
K
Site 40
S526
A
S
K
A
A
S
G
S
L
H
K
D
K
P
L
Site 41
T538
K
P
L
P
V
P
P
T
L
R
D
L
P
P
P
Site 42
Y552
P
P
P
P
D
R
P
Y
S
V
G
A
E
S
R
Site 43
S553
P
P
P
D
R
P
Y
S
V
G
A
E
S
R
P
Site 44
T568
Q
R
R
P
L
P
C
T
P
G
D
C
P
S
R
Site 45
S574
C
T
P
G
D
C
P
S
R
D
K
L
P
P
V
Site 46
S583
D
K
L
P
P
V
P
S
S
R
L
G
D
S
W
Site 47
S584
K
L
P
P
V
P
S
S
R
L
G
D
S
W
L
Site 48
S589
P
S
S
R
L
G
D
S
W
L
P
R
P
I
P
Site 49
S601
P
I
P
K
V
P
V
S
A
P
S
S
S
D
P
Site 50
S604
K
V
P
V
S
A
P
S
S
S
D
P
W
T
G
Site 51
S605
V
P
V
S
A
P
S
S
S
D
P
W
T
G
R
Site 52
S606
P
V
S
A
P
S
S
S
D
P
W
T
G
R
E
Site 53
T610
P
S
S
S
D
P
W
T
G
R
E
L
T
N
R
Site 54
T615
P
W
T
G
R
E
L
T
N
R
H
S
L
P
F
Site 55
S619
R
E
L
T
N
R
H
S
L
P
F
S
L
P
S
Site 56
S623
N
R
H
S
L
P
F
S
L
P
S
Q
M
E
P
Site 57
S626
S
L
P
F
S
L
P
S
Q
M
E
P
R
P
D
Site 58
S639
P
D
V
P
R
L
G
S
T
F
S
L
D
T
S
Site 59
T640
D
V
P
R
L
G
S
T
F
S
L
D
T
S
M
Site 60
S642
P
R
L
G
S
T
F
S
L
D
T
S
M
S
M
Site 61
T645
G
S
T
F
S
L
D
T
S
M
S
M
N
S
S
Site 62
S646
S
T
F
S
L
D
T
S
M
S
M
N
S
S
P
Site 63
S652
T
S
M
S
M
N
S
S
P
L
V
G
P
E
C
Site 64
S667
D
H
P
K
I
K
P
S
S
S
A
N
A
I
Y
Site 65
S668
H
P
K
I
K
P
S
S
S
A
N
A
I
Y
S
Site 66
S669
P
K
I
K
P
S
S
S
A
N
A
I
Y
S
L
Site 67
Y674
S
S
S
A
N
A
I
Y
S
L
A
A
R
P
L
Site 68
S675
S
S
A
N
A
I
Y
S
L
A
A
R
P
L
P
Site 69
T698
Q
C
E
G
E
E
D
T
E
Y
M
T
P
S
S
Site 70
Y700
E
G
E
E
D
T
E
Y
M
T
P
S
S
R
P
Site 71
T702
E
E
D
T
E
Y
M
T
P
S
S
R
P
L
R
Site 72
S704
D
T
E
Y
M
T
P
S
S
R
P
L
R
P
L
Site 73
S705
T
E
Y
M
T
P
S
S
R
P
L
R
P
L
D
Site 74
T713
R
P
L
R
P
L
D
T
S
Q
S
S
R
A
C
Site 75
S714
P
L
R
P
L
D
T
S
Q
S
S
R
A
C
D
Site 76
S716
R
P
L
D
T
S
Q
S
S
R
A
C
D
C
D
Site 77
S717
P
L
D
T
S
Q
S
S
R
A
C
D
C
D
Q
Site 78
Y731
Q
Q
I
D
S
C
T
Y
E
A
M
Y
N
I
Q
Site 79
Y735
S
C
T
Y
E
A
M
Y
N
I
Q
S
Q
A
P
Site 80
S739
E
A
M
Y
N
I
Q
S
Q
A
P
S
I
T
E
Site 81
S743
N
I
Q
S
Q
A
P
S
I
T
E
S
S
T
F
Site 82
S747
Q
A
P
S
I
T
E
S
S
T
F
G
E
G
N
Site 83
T749
P
S
I
T
E
S
S
T
F
G
E
G
N
L
A
Site 84
S767
A
N
T
G
P
E
E
S
E
N
E
D
D
G
Y
Site 85
Y774
S
E
N
E
D
D
G
Y
D
V
P
K
P
P
V
Site 86
T789
P
A
V
L
A
R
R
T
L
S
D
I
S
N
A
Site 87
S791
V
L
A
R
R
T
L
S
D
I
S
N
A
S
S
Site 88
S794
R
R
T
L
S
D
I
S
N
A
S
S
S
F
G
Site 89
S797
L
S
D
I
S
N
A
S
S
S
F
G
W
L
S
Site 90
S798
S
D
I
S
N
A
S
S
S
F
G
W
L
S
L
Site 91
S799
D
I
S
N
A
S
S
S
F
G
W
L
S
L
D
Site 92
S804
S
S
S
F
G
W
L
S
L
D
G
D
P
T
T
Site 93
T810
L
S
L
D
G
D
P
T
T
N
V
T
E
G
S
Site 94
T811
S
L
D
G
D
P
T
T
N
V
T
E
G
S
Q
Site 95
S817
T
T
N
V
T
E
G
S
Q
V
P
E
R
P
P
Site 96
S833
P
F
P
R
R
I
N
S
E
R
K
A
G
S
C
Site 97
S839
N
S
E
R
K
A
G
S
C
Q
Q
G
S
G
P
Site 98
S844
A
G
S
C
Q
Q
G
S
G
P
A
A
S
A
A
Site 99
S849
Q
G
S
G
P
A
A
S
A
A
T
A
S
P
Q
Site 100
T852
G
P
A
A
S
A
A
T
A
S
P
Q
L
S
S
Site 101
S858
A
T
A
S
P
Q
L
S
S
E
I
E
N
L
M
Site 102
S859
T
A
S
P
Q
L
S
S
E
I
E
N
L
M
S
Site 103
S866
S
E
I
E
N
L
M
S
Q
G
Y
S
Y
Q
D
Site 104
S870
N
L
M
S
Q
G
Y
S
Y
Q
D
I
Q
K
A
Site 105
S900
R
E
F
V
S
I
S
S
P
A
H
V
A
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation