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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBA1
Full Name:
Ubiquitin-like modifier-activating enzyme 1
Alias:
A1S9 protein; A1S9T; GXP1; UBA1, ubiquitin-activating enzyme E1; UBA1X; UBE1X; Ubiquitin-activating enzyme E1; Ubiquitin-activating enzyme E1 1; Ubiquitin-like modifier activating enzyme 1
Type:
Ubiquitin conjugating system
Mass (Da):
117849
Number AA:
1058
UniProt ID:
P22314
International Prot ID:
IPI00645078
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016874
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
S
S
S
P
L
S
K
K
R
R
Site 2
S7
_
M
S
S
S
P
L
S
K
K
R
R
V
S
G
Site 3
S13
L
S
K
K
R
R
V
S
G
P
D
P
K
P
G
Site 4
S21
G
P
D
P
K
P
G
S
N
C
S
P
A
Q
S
Site 5
S24
P
K
P
G
S
N
C
S
P
A
Q
S
V
L
S
Site 6
S28
S
N
C
S
P
A
Q
S
V
L
S
E
V
P
S
Site 7
S31
S
P
A
Q
S
V
L
S
E
V
P
S
V
P
T
Site 8
S35
S
V
L
S
E
V
P
S
V
P
T
N
G
M
A
Site 9
T38
S
E
V
P
S
V
P
T
N
G
M
A
K
N
G
Site 10
S46
N
G
M
A
K
N
G
S
E
A
D
I
D
E
G
Site 11
Y55
A
D
I
D
E
G
L
Y
S
R
Q
L
Y
V
L
Site 12
S56
D
I
D
E
G
L
Y
S
R
Q
L
Y
V
L
G
Site 13
Y60
G
L
Y
S
R
Q
L
Y
V
L
G
H
E
A
M
Site 14
T72
E
A
M
K
R
L
Q
T
S
S
V
L
V
S
G
Site 15
S73
A
M
K
R
L
Q
T
S
S
V
L
V
S
G
L
Site 16
S74
M
K
R
L
Q
T
S
S
V
L
V
S
G
L
R
Site 17
S113
T
A
Q
W
A
D
L
S
S
Q
F
Y
L
R
E
Site 18
S114
A
Q
W
A
D
L
S
S
Q
F
Y
L
R
E
E
Site 19
Y117
A
D
L
S
S
Q
F
Y
L
R
E
E
D
I
G
Site 20
S131
G
K
N
R
A
E
V
S
Q
P
R
L
A
E
L
Site 21
S140
P
R
L
A
E
L
N
S
Y
V
P
V
T
A
Y
Site 22
T167
Q
V
V
V
L
T
N
T
P
L
E
D
Q
L
R
Site 23
T191
I
K
L
V
V
A
D
T
R
G
L
F
G
Q
L
Site 24
T209
F
G
E
E
M
I
L
T
D
S
N
G
E
Q
P
Site 25
S211
E
E
M
I
L
T
D
S
N
G
E
Q
P
L
S
Site 26
S218
S
N
G
E
Q
P
L
S
A
M
V
S
M
V
T
Site 27
S222
Q
P
L
S
A
M
V
S
M
V
T
K
D
N
P
Site 28
S244
E
A
R
H
G
F
E
S
G
D
F
V
S
F
S
Site 29
S249
F
E
S
G
D
F
V
S
F
S
E
V
Q
G
M
Site 30
S251
S
G
D
F
V
S
F
S
E
V
Q
G
M
V
E
Site 31
Y273
E
I
K
V
L
G
P
Y
T
F
S
I
C
D
T
Site 32
T274
I
K
V
L
G
P
Y
T
F
S
I
C
D
T
S
Site 33
S284
I
C
D
T
S
N
F
S
D
Y
I
R
G
G
I
Site 34
Y286
D
T
S
N
F
S
D
Y
I
R
G
G
I
V
S
Site 35
S293
Y
I
R
G
G
I
V
S
Q
V
K
V
P
K
K
Site 36
S302
V
K
V
P
K
K
I
S
F
K
S
L
V
A
S
Site 37
S305
P
K
K
I
S
F
K
S
L
V
A
S
L
A
E
Site 38
S309
S
F
K
S
L
V
A
S
L
A
E
P
D
F
V
Site 39
T318
A
E
P
D
F
V
V
T
D
F
A
K
F
S
R
Site 40
S324
V
T
D
F
A
K
F
S
R
P
A
Q
L
H
I
Site 41
Y388
D
L
I
R
K
L
A
Y
V
A
A
G
D
L
A
Site 42
T440
P
E
D
K
E
V
L
T
E
D
K
C
L
Q
R
Site 43
Y471
E
K
L
G
K
Q
K
Y
F
L
V
G
A
G
A
Site 44
T503
E
G
G
E
I
I
V
T
D
M
D
T
I
E
K
Site 45
T507
I
I
V
T
D
M
D
T
I
E
K
S
N
L
N
Site 46
S511
D
M
D
T
I
E
K
S
N
L
N
R
Q
F
L
Site 47
T525
L
F
R
P
W
D
V
T
K
L
K
S
D
T
A
Site 48
S529
W
D
V
T
K
L
K
S
D
T
A
A
A
A
V
Site 49
S547
N
P
H
I
R
V
T
S
H
Q
N
R
V
G
P
Site 50
T556
Q
N
R
V
G
P
D
T
E
R
I
Y
D
D
D
Site 51
Y560
G
P
D
T
E
R
I
Y
D
D
D
F
F
Q
N
Site 52
Y583
D
N
V
D
A
R
M
Y
M
D
R
R
C
V
Y
Site 53
Y590
Y
M
D
R
R
C
V
Y
Y
R
K
P
L
L
E
Site 54
Y591
M
D
R
R
C
V
Y
Y
R
K
P
L
L
E
S
Site 55
T600
K
P
L
L
E
S
G
T
L
G
T
K
G
N
V
Site 56
T603
L
E
S
G
T
L
G
T
K
G
N
V
Q
V
V
Site 57
T615
Q
V
V
I
P
F
L
T
E
S
Y
S
S
S
Q
Site 58
S617
V
I
P
F
L
T
E
S
Y
S
S
S
Q
D
P
Site 59
S619
P
F
L
T
E
S
Y
S
S
S
Q
D
P
P
E
Site 60
S621
L
T
E
S
Y
S
S
S
Q
D
P
P
E
K
S
Site 61
S628
S
Q
D
P
P
E
K
S
I
P
I
C
T
L
K
Site 62
T633
E
K
S
I
P
I
C
T
L
K
N
F
P
N
A
Site 63
Y666
P
A
E
N
V
N
Q
Y
L
T
D
P
K
F
V
Site 64
T668
E
N
V
N
Q
Y
L
T
D
P
K
F
V
E
R
Site 65
T682
R
T
L
R
L
A
G
T
Q
P
L
E
V
L
E
Site 66
T735
N
F
P
P
D
Q
L
T
S
S
G
A
P
F
W
Site 67
S737
P
P
D
Q
L
T
S
S
G
A
P
F
W
S
G
Site 68
S743
S
S
G
A
P
F
W
S
G
P
K
R
C
P
H
Site 69
T753
K
R
C
P
H
P
L
T
F
D
V
N
N
P
L
Site 70
Y776
A
N
L
F
A
Q
T
Y
G
L
T
G
S
Q
D
Site 71
S781
Q
T
Y
G
L
T
G
S
Q
D
R
A
A
V
A
Site 72
T800
S
V
Q
V
P
E
F
T
P
K
S
G
V
K
I
Site 73
S803
V
P
E
F
T
P
K
S
G
V
K
I
H
V
S
Site 74
S810
S
G
V
K
I
H
V
S
D
Q
E
L
Q
S
A
Site 75
S816
V
S
D
Q
E
L
Q
S
A
N
A
S
V
D
D
Site 76
S820
E
L
Q
S
A
N
A
S
V
D
D
S
R
L
E
Site 77
S824
A
N
A
S
V
D
D
S
R
L
E
E
L
K
A
Site 78
T832
R
L
E
E
L
K
A
T
L
P
S
P
D
K
L
Site 79
S835
E
L
K
A
T
L
P
S
P
D
K
L
P
G
F
Site 80
Y845
K
L
P
G
F
K
M
Y
P
I
D
F
E
K
D
Site 81
Y873
S
N
L
R
A
E
N
Y
D
I
P
S
A
D
R
Site 82
S883
P
S
A
D
R
H
K
S
K
L
I
A
G
K
I
Site 83
S921
Q
G
H
R
Q
L
D
S
Y
K
N
G
F
L
N
Site 84
Y922
G
H
R
Q
L
D
S
Y
K
N
G
F
L
N
L
Site 85
Y947
L
A
A
P
R
H
Q
Y
Y
N
Q
E
W
T
L
Site 86
Y978
T
L
K
Q
F
L
D
Y
F
K
T
E
H
K
L
Site 87
T981
Q
F
L
D
Y
F
K
T
E
H
K
L
E
I
T
Site 88
T1016
E
R
L
D
Q
P
M
T
E
I
V
S
R
V
S
Site 89
S1023
T
E
I
V
S
R
V
S
K
R
K
L
G
R
H
Site 90
S1044
E
L
C
C
N
D
E
S
G
E
D
V
E
V
P
Site 91
Y1052
G
E
D
V
E
V
P
Y
V
R
Y
T
I
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation