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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TGM2
Full Name:
Protein-glutamine gamma-glutamyltransferase 2
Alias:
C polypeptide, protein-glutamine-gamma-glutamyltransferase; Protein-glutamine gamma-glutamyltransferase; TG(C); TGase C; TGase-H; TGC; Tissue transglutaminase; transglutaminase 2
Type:
Transferase; EC 2.3.2.13
Mass (Da):
77329
Number AA:
687
UniProt ID:
P21980
International Prot ID:
IPI00294578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016020
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0005509
GO:0003810
PhosphoSite+
KinaseNET
Biological Process:
GO:0045785
GO:0018149
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-glutamine gamma-glutamyltransferase 2 Y369 phosphosite-specific antibody AB-PN541#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN541#Protein-glutamine gamma-glutamyltransferase 2 (E366-G372, human) pY369 phosphopeptide - Powder PE-04ADQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADQ95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y50
L
H
F
E
G
R
N
Y
E
A
S
V
D
S
L
Site 2
S53
E
G
R
N
Y
E
A
S
V
D
S
L
T
F
S
Site 3
T73
A
P
S
Q
E
A
G
T
K
A
R
F
P
L
R
Site 4
T89
A
V
E
E
G
D
W
T
A
T
V
V
D
Q
Q
Site 5
T91
E
E
G
D
W
T
A
T
V
V
D
Q
Q
D
C
Site 6
S101
D
Q
Q
D
C
T
L
S
L
Q
L
T
T
P
A
Site 7
S122
Y
R
L
S
L
E
A
S
T
G
Y
Q
G
S
S
Site 8
Y125
S
L
E
A
S
T
G
Y
Q
G
S
S
F
V
L
Site 9
Y149
W
C
P
A
D
A
V
Y
L
D
S
E
E
E
R
Site 10
S152
A
D
A
V
Y
L
D
S
E
E
E
R
Q
E
Y
Site 11
Y159
S
E
E
E
R
Q
E
Y
V
L
T
Q
Q
G
F
Site 12
T162
E
R
Q
E
Y
V
L
T
Q
Q
G
F
I
Y
Q
Site 13
S212
K
N
A
G
R
D
C
S
R
R
S
S
P
V
Y
Site 14
S215
G
R
D
C
S
R
R
S
S
P
V
Y
V
G
R
Site 15
S216
R
D
C
S
R
R
S
S
P
V
Y
V
G
R
V
Site 16
Y219
S
R
R
S
S
P
V
Y
V
G
R
V
V
S
G
Site 17
Y245
L
G
R
W
D
N
N
Y
G
D
G
V
S
P
M
Site 18
S250
N
N
Y
G
D
G
V
S
P
M
S
W
I
G
S
Site 19
S257
S
P
M
S
W
I
G
S
V
D
I
L
R
R
W
Site 20
T299
G
I
P
T
R
V
V
T
N
Y
N
S
A
H
D
Site 21
Y301
P
T
R
V
V
T
N
Y
N
S
A
H
D
Q
N
Site 22
Y315
N
S
N
L
L
I
E
Y
F
R
N
E
F
G
E
Site 23
Y351
R
P
D
L
Q
P
G
Y
E
G
W
Q
A
L
D
Site 24
T360
G
W
Q
A
L
D
P
T
P
Q
E
K
S
E
G
Site 25
S365
D
P
T
P
Q
E
K
S
E
G
T
Y
C
C
G
Site 26
T368
P
Q
E
K
S
E
G
T
Y
C
C
G
P
V
P
Site 27
Y369
Q
E
K
S
E
G
T
Y
C
C
G
P
V
P
V
Protein-glutamine gamma-glutamyltransferase 2 Y369 phosphosite-specific antibody AB-PN541#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN541#Protein-glutamine gamma-glutamyltransferase 2 (E366-G372, human) pY369 phosphopeptide - Powder PE-04ADQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADQ95
Site 28
S385
A
I
K
E
G
D
L
S
T
K
Y
D
A
P
F
Site 29
T386
I
K
E
G
D
L
S
T
K
Y
D
A
P
F
V
Site 30
Y388
E
G
D
L
S
T
K
Y
D
A
P
F
V
F
A
Site 31
S415
D
D
G
S
V
H
K
S
I
N
R
S
L
I
V
Site 32
S427
L
I
V
G
L
K
I
S
T
K
S
V
G
R
D
Site 33
S430
G
L
K
I
S
T
K
S
V
G
R
D
E
R
E
Site 34
T440
R
D
E
R
E
D
I
T
H
T
Y
K
Y
P
E
Site 35
Y443
R
E
D
I
T
H
T
Y
K
Y
P
E
G
S
S
Site 36
Y445
D
I
T
H
T
Y
K
Y
P
E
G
S
S
E
E
Site 37
S450
Y
K
Y
P
E
G
S
S
E
E
R
E
A
F
T
Site 38
T471
K
L
A
E
K
E
E
T
G
M
A
M
R
I
R
Site 39
Y528
G
P
E
C
G
T
K
Y
L
L
N
L
N
L
E
Site 40
S538
N
L
N
L
E
P
F
S
E
K
S
V
P
L
C
Site 41
Y551
L
C
I
L
Y
E
K
Y
R
D
C
L
T
E
S
Site 42
T556
E
K
Y
R
D
C
L
T
E
S
N
L
I
K
V
Site 43
Y583
L
L
A
E
R
D
L
Y
L
E
N
P
E
I
K
Site 44
T635
G
L
T
E
E
Q
K
T
V
E
I
P
D
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation