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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HNF1A
Full Name:
Hepatocyte nuclear factor 1-alpha
Alias:
HNF1; HNF1 homeobox A; HNF-1A; HNFA; LFB1; Liver-specific transcription factor LF-B1; MODY3; TCF1; TCF-1; Transcription factor 1, hepatic (HNF1); Transcription factor-1
Type:
Uncharacterized protein
Mass (Da):
67356
Number AA:
631
UniProt ID:
P20823
International Prot ID:
IPI00025839
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0010843
GO:0046982
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0042593
GO:0030073
GO:0045893
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y36
A
L
G
E
P
G
P
Y
L
L
A
G
E
G
P
Site 2
S49
G
P
L
D
K
G
E
S
C
G
G
G
R
G
E
Site 3
T67
L
P
N
G
L
G
E
T
R
G
S
E
D
E
T
Site 4
S70
G
L
G
E
T
R
G
S
E
D
E
T
D
D
D
Site 5
T74
T
R
G
S
E
D
E
T
D
D
D
G
E
D
F
Site 6
T82
D
D
D
G
E
D
F
T
P
P
I
L
K
E
L
Site 7
S93
L
K
E
L
E
N
L
S
P
E
E
A
A
H
Q
Site 8
T136
P
Q
R
E
V
V
D
T
T
G
L
N
Q
S
H
Site 9
T137
Q
R
E
V
V
D
T
T
G
L
N
Q
S
H
L
Site 10
S142
D
T
T
G
L
N
Q
S
H
L
S
Q
H
L
N
Site 11
S145
G
L
N
Q
S
H
L
S
Q
H
L
N
K
G
T
Site 12
T152
S
Q
H
L
N
K
G
T
P
M
K
T
Q
K
R
Site 13
T156
N
K
G
T
P
M
K
T
Q
K
R
A
A
L
Y
Site 14
T164
Q
K
R
A
A
L
Y
T
W
Y
V
R
K
Q
R
Site 15
Y166
R
A
A
L
Y
T
W
Y
V
R
K
Q
R
E
V
Site 16
T190
G
G
L
I
E
E
P
T
G
D
E
L
P
T
K
Site 17
S210
R
F
K
W
G
P
A
S
Q
Q
I
L
F
Q
A
Site 18
Y218
Q
Q
I
L
F
Q
A
Y
E
R
Q
K
N
P
S
Site 19
S225
Y
E
R
Q
K
N
P
S
K
E
E
R
E
T
L
Site 20
T231
P
S
K
E
E
R
E
T
L
V
E
E
C
N
R
Site 21
S247
E
C
I
Q
R
G
V
S
P
S
Q
A
Q
G
L
Site 22
S249
I
Q
R
G
V
S
P
S
Q
A
Q
G
L
G
S
Site 23
T260
G
L
G
S
N
L
V
T
E
V
R
V
Y
N
W
Site 24
Y265
L
V
T
E
V
R
V
Y
N
W
F
A
N
R
R
Site 25
T285
R
H
K
L
A
M
D
T
Y
S
G
P
P
P
G
Site 26
Y286
H
K
L
A
M
D
T
Y
S
G
P
P
P
G
P
Site 27
S287
K
L
A
M
D
T
Y
S
G
P
P
P
G
P
G
Site 28
S303
G
P
A
L
P
A
H
S
S
P
G
L
P
P
P
Site 29
S304
P
A
L
P
A
H
S
S
P
G
L
P
P
P
A
Site 30
S313
G
L
P
P
P
A
L
S
P
S
K
V
H
G
V
Site 31
S315
P
P
P
A
L
S
P
S
K
V
H
G
V
R
Y
Site 32
Y322
S
K
V
H
G
V
R
Y
G
Q
P
A
T
S
E
Site 33
T330
G
Q
P
A
T
S
E
T
A
E
V
P
S
S
S
Site 34
S336
E
T
A
E
V
P
S
S
S
G
G
P
L
V
T
Site 35
T343
S
S
G
G
P
L
V
T
V
S
T
P
L
H
Q
Site 36
S352
S
T
P
L
H
Q
V
S
P
T
G
L
E
P
S
Site 37
S359
S
P
T
G
L
E
P
S
H
S
L
L
S
T
E
Site 38
S361
T
G
L
E
P
S
H
S
L
L
S
T
E
A
K
Site 39
S364
E
P
S
H
S
L
L
S
T
E
A
K
L
V
S
Site 40
T365
P
S
H
S
L
L
S
T
E
A
K
L
V
S
A
Site 41
S388
S
T
L
T
A
L
H
S
L
E
Q
T
S
P
G
Site 42
T392
A
L
H
S
L
E
Q
T
S
P
G
L
N
Q
Q
Site 43
S393
L
H
S
L
E
Q
T
S
P
G
L
N
Q
Q
P
Site 44
S421
I
G
P
G
E
P
A
S
L
G
P
T
F
T
N
Site 45
T425
E
P
A
S
L
G
P
T
F
T
N
T
G
A
S
Site 46
T458
S
M
G
S
S
L
T
T
L
Q
P
V
Q
F
S
Site 47
S465
T
L
Q
P
V
Q
F
S
Q
P
L
H
P
S
Y
Site 48
S471
F
S
Q
P
L
H
P
S
Y
Q
Q
P
L
M
P
Site 49
Y472
S
Q
P
L
H
P
S
Y
Q
Q
P
L
M
P
P
Site 50
S482
P
L
M
P
P
V
Q
S
H
V
T
Q
S
P
F
Site 51
T485
P
P
V
Q
S
H
V
T
Q
S
P
F
M
A
T
Site 52
S498
A
T
M
A
Q
L
Q
S
P
H
A
L
Y
S
H
Site 53
S504
Q
S
P
H
A
L
Y
S
H
K
P
E
V
A
Q
Site 54
Y512
H
K
P
E
V
A
Q
Y
T
H
T
G
L
L
P
Site 55
T539
A
L
A
S
L
T
P
T
K
Q
V
F
T
S
D
Site 56
S545
P
T
K
Q
V
F
T
S
D
T
E
A
S
S
E
Site 57
T547
K
Q
V
F
T
S
D
T
E
A
S
S
E
S
G
Site 58
S550
F
T
S
D
T
E
A
S
S
E
S
G
L
H
T
Site 59
S551
T
S
D
T
E
A
S
S
E
S
G
L
H
T
P
Site 60
T557
S
S
E
S
G
L
H
T
P
A
S
Q
A
T
T
Site 61
S560
S
G
L
H
T
P
A
S
Q
A
T
T
L
H
V
Site 62
T564
T
P
A
S
Q
A
T
T
L
H
V
P
S
Q
D
Site 63
S569
A
T
T
L
H
V
P
S
Q
D
P
A
G
I
Q
Site 64
S585
L
Q
P
A
H
R
L
S
A
S
P
T
V
S
S
Site 65
S587
P
A
H
R
L
S
A
S
P
T
V
S
S
S
S
Site 66
T589
H
R
L
S
A
S
P
T
V
S
S
S
S
L
V
Site 67
S594
S
P
T
V
S
S
S
S
L
V
L
Y
Q
S
S
Site 68
Y598
S
S
S
S
L
V
L
Y
Q
S
S
D
S
S
N
Site 69
S600
S
S
L
V
L
Y
Q
S
S
D
S
S
N
G
Q
Site 70
S601
S
L
V
L
Y
Q
S
S
D
S
S
N
G
Q
S
Site 71
S603
V
L
Y
Q
S
S
D
S
S
N
G
Q
S
H
L
Site 72
S604
L
Y
Q
S
S
D
S
S
N
G
Q
S
H
L
L
Site 73
S608
S
D
S
S
N
G
Q
S
H
L
L
P
S
N
H
Site 74
S613
G
Q
S
H
L
L
P
S
N
H
S
V
I
E
T
Site 75
T620
S
N
H
S
V
I
E
T
F
I
S
T
Q
M
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation