PhosphoNET

           
Protein Info 
   
Short Name:  NPR2
Full Name:  Atrial natriuretic peptide receptor 2
Alias:  ANPb; ANP-B; ANPRB; Atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor B precursor; Atrionatriuretic peptide receptor B; EC 4.6.1.2; GC-B; Guanylate cyclase; GUCY2B; Natriuretic peptide receptor B/guanylate cyclase B; NPRB
Type:  Protein kinase, dual-specificity; Lyase; Nucleotide Metabolism - purine; EC 4.6.1.2; Receptor, misc.; Guanylyl cyclase; RGC group; RGC family
Mass (Da):  117022
Number AA:  1047
UniProt ID:  P20594
International Prot ID:  IPI00024685
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021  GO:0005886   Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005525  GO:0004383 PhosphoSite+ KinaseNET
Biological Process:  GO:0006182  GO:0007166  GO:0007242 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S489MLEKELASMLWRIRW
Site 2S504EELQFGNSERYHKGA
Site 3Y507QFGNSERYHKGAGSR
Site 4S513RYHKGAGSRLTLSLR
Site 5T516KGAGSRLTLSLRGSS
Site 6S518AGSRLTLSLRGSSYG
Site 7S522LTLSLRGSSYGSLMT
Site 8S523TLSLRGSSYGSLMTA
Site 9Y524LSLRGSSYGSLMTAH
Site 10S526LRGSSYGSLMTAHGK
Site 11T529SSYGSLMTAHGKYQI
Site 12S603TEYCPRGSLQDILEN
Site 13S640FLHNSIISSHGSLKS
Site 14S641LHNSIISSHGSLKSS
Site 15S644SIISSHGSLKSSNCV
Site 16S647SSHGSLKSSNCVVDS
Site 17S648SHGSLKSSNCVVDSR
Site 18S667ITDYGLASFRSTAEP
Site 19S670YGLASFRSTAEPDDS
Site 20T671GLASFRSTAEPDDSH
Site 21S677STAEPDDSHALYAKK
Site 22Y681PDDSHALYAKKLWTA
Site 23S693WTAPELLSGNPLPTT
Site 24T700SGNPLPTTGMQKADV
Site 25S721LQEIALRSGPFYLEG
Site 26Y725ALRSGPFYLEGLDLS
Site 27S732YLEGLDLSPKEIVQK
Site 28Y747VRNGQRPYFRPSIDR
Site 29S751QRPYFRPSIDRTQLN
Site 30T755FRPSIDRTQLNEELV
Site 31Y808LLLRMEQYANNLEKL
Site 32T820EKLVEERTQAYLEEK
Site 33S841LYQILPHSVAEQLKR
Site 34T851EQLKRGETVQAEAFD
Site 35S916GDAYMVVSGLPGRNG
Site 36S943ALLDAVSSFRIRHRP
Site 37S988GDTVNTASRMESNGQ
Site 38S992NTASRMESNGQALKI
Site 39S1002QALKIHVSSTTKDAL
Site 40T1033KGKGKMRTYWLLGER
Site 41Y1034GKGKMRTYWLLGERK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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