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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCNA2
Full Name:
Cyclin-A2
Alias:
CCN1; CCNA; CGA2; Cyclin A; Cyclin A2
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
48537
Number AA:
432
UniProt ID:
P20248
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0007095
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
L
G
N
S
A
P
G
P
A
T
R
Site 2
S16
P
A
T
R
E
A
G
S
A
L
L
A
L
Q
Q
Site 3
S55
A
A
L
A
V
L
K
S
G
N
P
R
G
L
A
Site 4
T69
A
Q
Q
Q
R
P
K
T
R
R
V
A
P
L
K
Site 5
T86
P
V
N
D
E
H
V
T
V
P
P
W
K
A
N
Site 6
S133
L
A
F
N
S
A
I
S
L
P
G
P
R
K
P
Site 7
Y146
K
P
L
V
P
L
D
Y
P
M
D
G
S
F
E
Site 8
S151
L
D
Y
P
M
D
G
S
F
E
S
P
H
T
M
Site 9
S154
P
M
D
G
S
F
E
S
P
H
T
M
D
M
S
Site 10
S161
S
P
H
T
M
D
M
S
I
V
L
E
D
E
K
Site 11
S171
L
E
D
E
K
P
V
S
V
N
E
V
P
D
Y
Site 12
Y178
S
V
N
E
V
P
D
Y
H
E
D
I
H
T
Y
Site 13
T184
D
Y
H
E
D
I
H
T
Y
L
R
E
M
E
V
Site 14
Y185
Y
H
E
D
I
H
T
Y
L
R
E
M
E
V
K
Site 15
T207
M
K
K
Q
P
D
I
T
N
S
M
R
A
I
L
Site 16
S209
K
Q
P
D
I
T
N
S
M
R
A
I
L
V
D
Site 17
S244
N
Y
I
D
R
F
L
S
S
M
S
V
L
R
G
Site 18
S245
Y
I
D
R
F
L
S
S
M
S
V
L
R
G
K
Site 19
S247
D
R
F
L
S
S
M
S
V
L
R
G
K
L
Q
Site 20
Y271
A
S
K
F
E
E
I
Y
P
P
E
V
A
E
F
Site 21
Y280
P
E
V
A
E
F
V
Y
I
T
D
D
T
Y
T
Site 22
T285
F
V
Y
I
T
D
D
T
Y
T
K
K
Q
V
L
Site 23
Y286
V
Y
I
T
D
D
T
Y
T
K
K
Q
V
L
R
Site 24
Y318
V
N
Q
F
L
T
Q
Y
F
L
H
Q
Q
P
A
Site 25
S371
L
Y
T
V
T
G
Q
S
W
P
E
S
L
I
R
Site 26
S375
T
G
Q
S
W
P
E
S
L
I
R
K
T
G
Y
Site 27
T380
P
E
S
L
I
R
K
T
G
Y
T
L
E
S
L
Site 28
Y382
S
L
I
R
K
T
G
Y
T
L
E
S
L
K
P
Site 29
T383
L
I
R
K
T
G
Y
T
L
E
S
L
K
P
C
Site 30
S386
K
T
G
Y
T
L
E
S
L
K
P
C
L
M
D
Site 31
Y398
L
M
D
L
H
Q
T
Y
L
K
A
P
Q
H
A
Site 32
S408
A
P
Q
H
A
Q
Q
S
I
R
E
K
Y
K
N
Site 33
Y413
Q
Q
S
I
R
E
K
Y
K
N
S
K
Y
H
G
Site 34
Y418
E
K
Y
K
N
S
K
Y
H
G
V
S
L
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation