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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFkB-p105
Full Name:
Nuclear factor NF-kappa-B p105 subunit
Alias:
DNA-binding factor KBF1; EBP-1; KBF1; NF-kappaB; NF-kappa-B1 p84/NF-kappa-B1 p98; NFKB1; NFkB-p50; Nuclear factor NF-kappa-B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; P105; P50
Type:
Transcription protein
Mass (Da):
105356
Number AA:
968
UniProt ID:
P19838
International Prot ID:
IPI00788987
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033256
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0010843
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
A
E
D
D
P
Y
L
G
R
P
E
Q
M
Site 2
S20
Q
M
F
H
L
D
P
S
L
T
H
T
I
F
N
Site 3
T22
F
H
L
D
P
S
L
T
H
T
I
F
N
P
E
Site 4
T39
Q
P
Q
M
A
L
P
T
D
G
P
Y
L
Q
I
Site 5
Y43
A
L
P
T
D
G
P
Y
L
Q
I
L
E
Q
P
Site 6
Y59
Q
R
G
F
R
F
R
Y
V
C
E
G
P
S
H
Site 7
S65
R
Y
V
C
E
G
P
S
H
G
G
L
P
G
A
Site 8
S73
H
G
G
L
P
G
A
S
S
E
K
N
K
K
S
Site 9
S74
G
G
L
P
G
A
S
S
E
K
N
K
K
S
Y
Site 10
S80
S
S
E
K
N
K
K
S
Y
P
Q
V
K
I
C
Site 11
Y81
S
E
K
N
K
K
S
Y
P
Q
V
K
I
C
N
Site 12
T124
H
C
E
D
G
I
C
T
V
T
A
G
P
K
D
Site 13
T158
E
T
L
E
A
R
M
T
E
A
C
I
R
G
Y
Site 14
Y165
T
E
A
C
I
R
G
Y
N
P
G
L
L
V
H
Site 15
S223
F
T
A
F
L
P
D
S
T
G
S
F
T
R
R
Site 16
S226
F
L
P
D
S
T
G
S
F
T
R
R
L
E
P
Site 17
T228
P
D
S
T
G
S
F
T
R
R
L
E
P
V
V
Site 18
S236
R
R
L
E
P
V
V
S
D
A
I
Y
D
S
K
Site 19
Y240
P
V
V
S
D
A
I
Y
D
S
K
A
P
N
A
Site 20
S242
V
S
D
A
I
Y
D
S
K
A
P
N
A
S
N
Site 21
T258
K
I
V
R
M
D
R
T
A
G
C
V
T
G
G
Site 22
Y285
D
D
I
Q
I
R
F
Y
E
E
E
E
N
G
G
Site 23
S301
W
E
G
F
G
D
F
S
P
T
D
V
H
R
Q
Site 24
T315
Q
F
A
I
V
F
K
T
P
K
Y
K
D
I
N
Site 25
Y318
I
V
F
K
T
P
K
Y
K
D
I
N
I
T
K
Site 26
T324
K
Y
K
D
I
N
I
T
K
P
A
S
V
F
V
Site 27
S328
I
N
I
T
K
P
A
S
V
F
V
Q
L
R
R
Site 28
S337
F
V
Q
L
R
R
K
S
D
L
E
T
S
E
P
Site 29
T341
R
R
K
S
D
L
E
T
S
E
P
K
P
F
L
Site 30
S342
R
K
S
D
L
E
T
S
E
P
K
P
F
L
Y
Site 31
Y349
S
E
P
K
P
F
L
Y
Y
P
E
I
K
D
K
Site 32
Y350
E
P
K
P
F
L
Y
Y
P
E
I
K
D
K
E
Site 33
S371
Q
K
L
M
P
N
F
S
D
S
F
G
G
G
S
Site 34
S373
L
M
P
N
F
S
D
S
F
G
G
G
S
G
A
Site 35
S378
S
D
S
F
G
G
G
S
G
A
G
A
G
G
G
Site 36
S390
G
G
G
G
M
F
G
S
G
G
G
G
G
G
T
Site 37
T397
S
G
G
G
G
G
G
T
G
S
T
G
P
G
Y
Site 38
S399
G
G
G
G
G
T
G
S
T
G
P
G
Y
S
F
Site 39
T400
G
G
G
G
T
G
S
T
G
P
G
Y
S
F
P
Site 40
Y404
T
G
S
T
G
P
G
Y
S
F
P
H
Y
G
F
Site 41
S405
G
S
T
G
P
G
Y
S
F
P
H
Y
G
F
P
Site 42
Y409
P
G
Y
S
F
P
H
Y
G
F
P
T
Y
G
G
Site 43
T413
F
P
H
Y
G
F
P
T
Y
G
G
I
T
F
H
Site 44
Y414
P
H
Y
G
F
P
T
Y
G
G
I
T
F
H
P
Site 45
T418
F
P
T
Y
G
G
I
T
F
H
P
G
T
T
K
Site 46
S426
F
H
P
G
T
T
K
S
N
A
G
M
K
H
G
Site 47
T434
N
A
G
M
K
H
G
T
M
D
T
E
S
K
K
Site 48
T437
M
K
H
G
T
M
D
T
E
S
K
K
D
P
E
Site 49
S439
H
G
T
M
D
T
E
S
K
K
D
P
E
G
C
Site 50
S449
D
P
E
G
C
D
K
S
D
D
K
N
T
V
N
Site 51
T454
D
K
S
D
D
K
N
T
V
N
L
F
G
K
V
Site 52
S472
T
E
Q
D
Q
E
P
S
E
A
T
V
G
N
G
Site 53
T484
G
N
G
E
V
T
L
T
Y
A
T
G
T
K
E
Site 54
Y485
N
G
E
V
T
L
T
Y
A
T
G
T
K
E
E
Site 55
Y519
H
A
N
A
L
F
D
Y
A
V
T
G
D
V
K
Site 56
T536
L
A
V
Q
R
H
L
T
A
V
Q
D
E
N
G
Site 57
Y582
I
N
M
R
N
D
L
Y
Q
T
P
L
H
L
A
Site 58
S684
V
N
A
Q
E
Q
K
S
G
R
T
A
L
H
L
Site 59
S714
E
G
D
A
H
V
D
S
T
T
Y
D
G
T
T
Site 60
T715
G
D
A
H
V
D
S
T
T
Y
D
G
T
T
P
Site 61
T716
D
A
H
V
D
S
T
T
Y
D
G
T
T
P
L
Site 62
T721
S
T
T
Y
D
G
T
T
P
L
H
I
A
A
G
Site 63
Y754
V
E
N
F
E
P
L
Y
D
L
D
D
S
W
E
Site 64
S759
P
L
Y
D
L
D
D
S
W
E
N
A
G
E
D
Site 65
Y793
D
I
L
N
G
K
P
Y
E
P
E
F
T
S
D
Site 66
T798
K
P
Y
E
P
E
F
T
S
D
D
L
L
A
Q
Site 67
S799
P
Y
E
P
E
F
T
S
D
D
L
L
A
Q
G
Site 68
Y820
E
D
V
K
L
Q
L
Y
K
L
L
E
I
P
D
Site 69
T834
D
P
D
K
N
W
A
T
L
A
Q
K
L
G
L
Site 70
S851
L
N
N
A
F
R
L
S
P
A
P
S
K
T
L
Site 71
S855
F
R
L
S
P
A
P
S
K
T
L
M
D
N
Y
Site 72
T857
L
S
P
A
P
S
K
T
L
M
D
N
Y
E
V
Site 73
Y862
S
K
T
L
M
D
N
Y
E
V
S
G
G
T
V
Site 74
S892
I
E
V
I
Q
A
A
S
S
P
V
K
T
T
S
Site 75
S893
E
V
I
Q
A
A
S
S
P
V
K
T
T
S
Q
Site 76
T897
A
A
S
S
P
V
K
T
T
S
Q
A
H
S
L
Site 77
S899
S
S
P
V
K
T
T
S
Q
A
H
S
L
P
L
Site 78
S903
K
T
T
S
Q
A
H
S
L
P
L
S
P
A
S
Site 79
S907
Q
A
H
S
L
P
L
S
P
A
S
T
R
Q
Q
Site 80
S910
S
L
P
L
S
P
A
S
T
R
Q
Q
I
D
E
Site 81
T911
L
P
L
S
P
A
S
T
R
Q
Q
I
D
E
L
Site 82
S921
Q
I
D
E
L
R
D
S
D
S
V
C
D
S
G
Site 83
S923
D
E
L
R
D
S
D
S
V
C
D
S
G
V
E
Site 84
S927
D
S
D
S
V
C
D
S
G
V
E
T
S
F
R
Site 85
T931
V
C
D
S
G
V
E
T
S
F
R
K
L
S
F
Site 86
S932
C
D
S
G
V
E
T
S
F
R
K
L
S
F
T
Site 87
S937
E
T
S
F
R
K
L
S
F
T
E
S
L
T
S
Site 88
T939
S
F
R
K
L
S
F
T
E
S
L
T
S
G
A
Site 89
S941
R
K
L
S
F
T
E
S
L
T
S
G
A
S
L
Site 90
T943
L
S
F
T
E
S
L
T
S
G
A
S
L
L
T
Site 91
T950
T
S
G
A
S
L
L
T
L
N
K
M
P
H
D
Site 92
Y958
L
N
K
M
P
H
D
Y
G
Q
E
G
P
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation