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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC9A1
Full Name:
Sodium/hydrogen exchanger 1
Alias:
APNH; APNH1; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; NHE1; SL9A1; Solute carrier family 9 (sodium/hydrogen exchanger) member 1; Solute carrier family 9 member 1
Type:
Transport protein
Mass (Da):
90763
Number AA:
815
UniProt ID:
P19634
International Prot ID:
IPI00020060
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0031402
PhosphoSite+
KinaseNET
Biological Process:
GO:0006885
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
S
G
I
C
G
L
S
P
H
R
I
F
P
S
Site 2
S40
R
S
H
G
L
Q
L
S
P
T
A
S
T
I
R
Site 3
T42
H
G
L
Q
L
S
P
T
A
S
T
I
R
S
S
Site 4
S44
L
Q
L
S
P
T
A
S
T
I
R
S
S
E
P
Site 5
T45
Q
L
S
P
T
A
S
T
I
R
S
S
E
P
P
Site 6
S48
P
T
A
S
T
I
R
S
S
E
P
P
R
E
R
Site 7
S49
T
A
S
T
I
R
S
S
E
P
P
R
E
R
S
Site 8
S56
S
E
P
P
R
E
R
S
I
G
D
V
T
T
A
Site 9
T61
E
R
S
I
G
D
V
T
T
A
P
P
E
V
T
Site 10
T62
R
S
I
G
D
V
T
T
A
P
P
E
V
T
P
Site 11
T68
T
T
A
P
P
E
V
T
P
E
S
R
P
V
N
Site 12
S71
P
P
E
V
T
P
E
S
R
P
V
N
H
S
V
Site 13
S77
E
S
R
P
V
N
H
S
V
T
D
H
G
M
K
Site 14
T97
P
V
L
G
I
D
Y
T
H
V
R
T
P
F
E
Site 15
T101
I
D
Y
T
H
V
R
T
P
F
E
I
S
L
W
Site 16
T152
L
I
K
G
V
G
E
T
P
P
F
L
Q
S
D
Site 17
S158
E
T
P
P
F
L
Q
S
D
V
F
F
L
F
L
Site 18
S324
A
F
T
S
R
F
T
S
H
I
R
V
I
E
P
Site 19
Y366
S
G
V
V
M
R
P
Y
V
E
A
N
I
S
H
Site 20
S372
P
Y
V
E
A
N
I
S
H
K
S
H
T
T
I
Site 21
Y381
K
S
H
T
T
I
K
Y
F
L
K
M
W
S
S
Site 22
S517
K
K
Q
E
T
K
R
S
I
N
E
E
I
H
T
Site 23
T524
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
Site 24
Y557
L
N
R
F
N
K
K
Y
V
K
K
C
L
I
A
Site 25
Y577
E
P
Q
L
I
A
F
Y
H
K
M
E
M
K
Q
Site 26
S599
G
G
M
G
K
I
P
S
A
V
S
T
V
S
M
Site 27
S602
G
K
I
P
S
A
V
S
T
V
S
M
Q
N
I
Site 28
T603
K
I
P
S
A
V
S
T
V
S
M
Q
N
I
H
Site 29
S605
P
S
A
V
S
T
V
S
M
Q
N
I
H
P
K
Site 30
S613
M
Q
N
I
H
P
K
S
L
P
S
E
R
I
L
Site 31
S616
I
H
P
K
S
L
P
S
E
R
I
L
P
A
L
Site 32
S624
E
R
I
L
P
A
L
S
K
D
K
E
E
E
I
Site 33
T642
L
R
N
N
L
Q
K
T
R
Q
R
L
R
S
Y
Site 34
S648
K
T
R
Q
R
L
R
S
Y
N
R
H
T
L
V
Site 35
Y649
T
R
Q
R
L
R
S
Y
N
R
H
T
L
V
A
Site 36
T653
L
R
S
Y
N
R
H
T
L
V
A
D
P
Y
E
Site 37
Y659
H
T
L
V
A
D
P
Y
E
E
A
W
N
Q
M
Site 38
Y683
L
E
Q
K
I
N
N
Y
L
T
V
P
A
H
K
Site 39
T685
Q
K
I
N
N
Y
L
T
V
P
A
H
K
L
D
Site 40
S693
V
P
A
H
K
L
D
S
P
T
M
S
R
A
R
Site 41
T695
A
H
K
L
D
S
P
T
M
S
R
A
R
I
G
Site 42
S697
K
L
D
S
P
T
M
S
R
A
R
I
G
S
D
Site 43
S703
M
S
R
A
R
I
G
S
D
P
L
A
Y
E
P
Site 44
Y708
I
G
S
D
P
L
A
Y
E
P
K
E
D
L
P
Site 45
T718
K
E
D
L
P
V
I
T
I
D
P
A
S
P
Q
Site 46
S723
V
I
T
I
D
P
A
S
P
Q
S
P
E
S
V
Site 47
S726
I
D
P
A
S
P
Q
S
P
E
S
V
D
L
V
Site 48
S729
A
S
P
Q
S
P
E
S
V
D
L
V
N
E
E
Site 49
S745
K
G
K
V
L
G
L
S
R
D
P
A
K
V
A
Site 50
S766
D
G
G
I
M
M
R
S
K
E
T
S
S
P
G
Site 51
S770
M
M
R
S
K
E
T
S
S
P
G
T
D
D
V
Site 52
S771
M
R
S
K
E
T
S
S
P
G
T
D
D
V
F
Site 53
T774
K
E
T
S
S
P
G
T
D
D
V
F
T
P
A
Site 54
T779
P
G
T
D
D
V
F
T
P
A
P
S
D
S
P
Site 55
S783
D
V
F
T
P
A
P
S
D
S
P
S
S
Q
R
Site 56
S785
F
T
P
A
P
S
D
S
P
S
S
Q
R
I
Q
Site 57
S787
P
A
P
S
D
S
P
S
S
Q
R
I
Q
R
C
Site 58
S788
A
P
S
D
S
P
S
S
Q
R
I
Q
R
C
L
Site 59
S796
Q
R
I
Q
R
C
L
S
D
P
G
P
H
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation