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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WT1
Full Name:
Wilms tumor protein
Alias:
WT33
Type:
Transcription protein
Mass (Da):
49188
Number AA:
449
UniProt ID:
P19544
International Prot ID:
IPI00743932
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016607
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0010843
GO:0016563
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
D
F
A
P
P
G
A
S
A
Y
G
S
L
G
G
Site 2
Y48
A
P
P
G
A
S
A
Y
G
S
L
G
G
P
A
Site 3
S50
P
G
A
S
A
Y
G
S
L
G
G
P
A
P
P
Site 4
S70
P
P
P
P
P
P
H
S
F
I
K
Q
E
P
S
Site 5
S77
S
F
I
K
Q
E
P
S
W
G
G
A
E
P
H
Site 6
T101
V
H
F
S
G
Q
F
T
G
T
A
G
A
C
R
Site 7
Y109
G
T
A
G
A
C
R
Y
G
P
F
G
P
P
P
Site 8
S118
P
F
G
P
P
P
P
S
Q
A
S
S
G
Q
A
Site 9
S122
P
P
P
S
Q
A
S
S
G
Q
A
R
M
F
P
Site 10
Y133
R
M
F
P
N
A
P
Y
L
P
S
C
L
E
S
Site 11
S136
P
N
A
P
Y
L
P
S
C
L
E
S
Q
P
A
Site 12
S140
Y
L
P
S
C
L
E
S
Q
P
A
I
R
N
Q
Site 13
S150
A
I
R
N
Q
G
Y
S
T
V
T
F
D
G
T
Site 14
T153
N
Q
G
Y
S
T
V
T
F
D
G
T
P
S
Y
Site 15
T157
S
T
V
T
F
D
G
T
P
S
Y
G
H
T
P
Site 16
S159
V
T
F
D
G
T
P
S
Y
G
H
T
P
S
H
Site 17
Y160
T
F
D
G
T
P
S
Y
G
H
T
P
S
H
H
Site 18
T163
G
T
P
S
Y
G
H
T
P
S
H
H
A
A
Q
Site 19
S165
P
S
Y
G
H
T
P
S
H
H
A
A
Q
F
P
Site 20
S175
A
A
Q
F
P
N
H
S
F
K
H
E
D
P
M
Site 21
S187
D
P
M
G
Q
Q
G
S
L
G
E
Q
Q
Y
S
Site 22
Y193
G
S
L
G
E
Q
Q
Y
S
V
P
P
P
V
Y
Site 23
S194
S
L
G
E
Q
Q
Y
S
V
P
P
P
V
Y
G
Site 24
Y200
Y
S
V
P
P
P
V
Y
G
C
H
T
P
T
D
Site 25
T204
P
P
V
Y
G
C
H
T
P
T
D
S
C
T
G
Site 26
T206
V
Y
G
C
H
T
P
T
D
S
C
T
G
S
Q
Site 27
S208
G
C
H
T
P
T
D
S
C
T
G
S
Q
A
L
Site 28
T210
H
T
P
T
D
S
C
T
G
S
Q
A
L
L
L
Site 29
S212
P
T
D
S
C
T
G
S
Q
A
L
L
L
R
T
Site 30
T219
S
Q
A
L
L
L
R
T
P
Y
S
S
D
N
L
Site 31
Y221
A
L
L
L
R
T
P
Y
S
S
D
N
L
Y
Q
Site 32
S222
L
L
L
R
T
P
Y
S
S
D
N
L
Y
Q
M
Site 33
S223
L
L
R
T
P
Y
S
S
D
N
L
Y
Q
M
T
Site 34
Y227
P
Y
S
S
D
N
L
Y
Q
M
T
S
Q
L
E
Site 35
S254
L
K
G
V
A
A
G
S
S
S
S
V
K
W
T
Site 36
S256
G
V
A
A
G
S
S
S
S
V
K
W
T
E
G
Site 37
T261
S
S
S
S
V
K
W
T
E
G
Q
S
N
H
S
Site 38
T269
E
G
Q
S
N
H
S
T
G
Y
E
S
D
N
H
Site 39
T277
G
Y
E
S
D
N
H
T
T
P
I
L
C
G
A
Site 40
T278
Y
E
S
D
N
H
T
T
P
I
L
C
G
A
Q
Site 41
T290
G
A
Q
Y
R
I
H
T
H
G
V
F
R
G
I
Site 42
T309
R
V
P
G
V
A
P
T
L
V
R
S
A
S
E
Site 43
S313
V
A
P
T
L
V
R
S
A
S
E
T
S
E
K
Site 44
S315
P
T
L
V
R
S
A
S
E
T
S
E
K
R
P
Site 45
T317
L
V
R
S
A
S
E
T
S
E
K
R
P
F
M
Site 46
S318
V
R
S
A
S
E
T
S
E
K
R
P
F
M
C
Site 47
Y334
Y
P
G
C
N
K
R
Y
F
K
L
S
H
L
Q
Site 48
T348
Q
M
H
S
R
K
H
T
G
E
K
P
Y
Q
C
Site 49
Y353
K
H
T
G
E
K
P
Y
Q
C
D
F
K
D
C
Site 50
S365
K
D
C
E
R
R
F
S
R
S
D
Q
L
K
R
Site 51
S367
C
E
R
R
F
S
R
S
D
Q
L
K
R
H
Q
Site 52
T378
K
R
H
Q
R
R
H
T
G
V
K
P
F
Q
C
Site 53
S393
K
T
C
Q
R
K
F
S
R
S
D
H
L
K
T
Site 54
S395
C
Q
R
K
F
S
R
S
D
H
L
K
T
H
T
Site 55
T400
S
R
S
D
H
L
K
T
H
T
R
T
H
T
G
Site 56
T406
K
T
H
T
R
T
H
T
G
K
T
S
E
K
P
Site 57
S410
R
T
H
T
G
K
T
S
E
K
P
F
S
C
R
Site 58
S415
K
T
S
E
K
P
F
S
C
R
W
P
S
C
Q
Site 59
S428
C
Q
K
K
F
A
R
S
D
E
L
V
R
H
H
Site 60
T443
N
M
H
Q
R
N
M
T
K
L
Q
L
A
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation