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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XPB
Full Name:
TFIIH basal transcription factor complex helicase XPB subunit
Alias:
Basic transcription factor 2 89 kDa subunit; BTF2; BTF2-p89; DNA excision repair protein ERCC3; DNA excision repair protein ERCC-3; DNA-repair protein complementing XP-B cells; ERCC3; Excision repair cross-complementing rodent repair deficiency, complementation group 3; Excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing); GTF2H; RAD25; TFIIH; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; Xeroderma pigmentosum group B complementing; Xeroderma pigmentosum group B complementing protein; XPBC
Type:
EC 3.6.1.-; Helicase; DNA repair; Transcription factor
Mass (Da):
89278
Number AA:
782
UniProt ID:
P19447
International Prot ID:
IPI00291364
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005675
Uniprot
OncoNet
Molecular Function:
GO:0043138
GO:0005524
GO:0004003
PhosphoSite+
KinaseNET
Biological Process:
GO:0006265
GO:0006368
GO:0000075
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
D
R
D
K
K
K
S
R
K
R
H
Y
E
D
Site 2
Y19
K
K
S
R
K
R
H
Y
E
D
E
E
D
D
E
Site 3
S40
D
P
Q
E
A
V
P
S
A
A
G
K
Q
V
D
Site 4
S49
A
G
K
Q
V
D
E
S
G
T
K
V
D
E
Y
Site 5
Y56
S
G
T
K
V
D
E
Y
G
A
K
D
Y
R
L
Site 6
Y61
D
E
Y
G
A
K
D
Y
R
L
Q
M
P
L
K
Site 7
T72
M
P
L
K
D
D
H
T
S
R
P
L
W
V
A
Site 8
T111
A
E
P
V
C
R
P
T
H
V
H
E
Y
K
L
Site 9
T119
H
V
H
E
Y
K
L
T
A
Y
S
L
Y
A
A
Site 10
S134
V
S
V
G
L
Q
T
S
D
I
T
E
Y
L
R
Site 11
Y139
Q
T
S
D
I
T
E
Y
L
R
K
L
S
K
T
Site 12
S144
T
E
Y
L
R
K
L
S
K
T
G
V
P
D
G
Site 13
T146
Y
L
R
K
L
S
K
T
G
V
P
D
G
I
M
Site 14
Y175
L
V
L
K
H
N
R
Y
F
V
E
S
C
H
P
Site 15
S202
R
E
C
R
L
R
N
S
E
G
E
A
T
E
L
Site 16
T207
R
N
S
E
G
E
A
T
E
L
I
T
E
T
F
Site 17
S216
L
I
T
E
T
F
T
S
K
S
A
I
S
K
T
Site 18
S218
T
E
T
F
T
S
K
S
A
I
S
K
T
A
E
Site 19
S221
F
T
S
K
S
A
I
S
K
T
A
E
S
S
G
Site 20
T223
S
K
S
A
I
S
K
T
A
E
S
S
G
G
P
Site 21
S227
I
S
K
T
A
E
S
S
G
G
P
S
T
S
R
Site 22
S231
A
E
S
S
G
G
P
S
T
S
R
V
T
D
P
Site 23
T232
E
S
S
G
G
P
S
T
S
R
V
T
D
P
Q
Site 24
S233
S
S
G
G
P
S
T
S
R
V
T
D
P
Q
G
Site 25
T236
G
P
S
T
S
R
V
T
D
P
Q
G
K
S
D
Site 26
S242
V
T
D
P
Q
G
K
S
D
I
P
M
D
L
F
Site 27
Y252
P
M
D
L
F
D
F
Y
E
Q
M
D
K
D
E
Site 28
T265
D
E
E
E
E
E
E
T
Q
T
V
S
F
E
V
Site 29
T267
E
E
E
E
E
T
Q
T
V
S
F
E
V
K
Q
Site 30
S269
E
E
E
T
Q
T
V
S
F
E
V
K
Q
E
M
Site 31
Y289
K
R
C
I
H
L
E
Y
P
L
L
A
E
Y
D
Site 32
Y295
E
Y
P
L
L
A
E
Y
D
F
R
N
D
S
V
Site 33
S301
E
Y
D
F
R
N
D
S
V
N
P
D
I
N
I
Site 34
Y319
P
T
A
V
L
R
P
Y
Q
E
K
S
L
R
K
Site 35
S323
L
R
P
Y
Q
E
K
S
L
R
K
M
F
G
N
Site 36
S370
V
L
G
N
S
A
V
S
V
E
Q
W
K
A
Q
Site 37
T393
D
S
Q
I
C
R
F
T
S
D
A
K
D
K
P
Site 38
S394
S
Q
I
C
R
F
T
S
D
A
K
D
K
P
I
Site 39
S404
K
D
K
P
I
G
C
S
V
A
I
S
T
Y
S
Site 40
S411
S
V
A
I
S
T
Y
S
M
L
G
H
T
T
K
Site 41
T469
C
K
L
G
L
T
A
T
L
V
R
E
D
D
K
Site 42
Y501
M
E
L
Q
N
N
G
Y
I
A
K
V
Q
C
A
Site 43
Y519
C
P
M
S
P
E
F
Y
R
E
Y
V
A
I
K
Site 44
Y522
S
P
E
F
Y
R
E
Y
V
A
I
K
T
K
K
Site 45
T527
R
E
Y
V
A
I
K
T
K
K
R
I
L
L
Y
Site 46
Y534
T
K
K
R
I
L
L
Y
T
M
N
P
N
K
F
Site 47
T535
K
K
R
I
L
L
Y
T
M
N
P
N
K
F
R
Site 48
Y579
A
I
R
L
N
K
P
Y
I
Y
G
P
T
S
Q
Site 49
Y581
R
L
N
K
P
Y
I
Y
G
P
T
S
Q
G
E
Site 50
S585
P
Y
I
Y
G
P
T
S
Q
G
E
R
M
Q
I
Site 51
S614
I
S
K
V
G
D
T
S
F
D
L
P
E
A
N
Site 52
S627
A
N
V
L
I
Q
I
S
S
H
G
G
S
R
R
Site 53
S628
N
V
L
I
Q
I
S
S
H
G
G
S
R
R
Q
Site 54
S632
Q
I
S
S
H
G
G
S
R
R
Q
E
A
Q
R
Site 55
Y655
K
G
M
V
A
E
E
Y
N
A
F
F
Y
S
L
Site 56
Y660
E
E
Y
N
A
F
F
Y
S
L
V
S
Q
D
T
Site 57
S661
E
Y
N
A
F
F
Y
S
L
V
S
Q
D
T
Q
Site 58
T667
Y
S
L
V
S
Q
D
T
Q
E
M
A
Y
S
T
Site 59
S673
D
T
Q
E
M
A
Y
S
T
K
R
Q
R
F
L
Site 60
Y685
R
F
L
V
D
Q
G
Y
S
F
K
V
I
T
K
Site 61
T705
E
E
D
L
A
F
S
T
K
E
E
Q
Q
Q
L
Site 62
S735
V
V
A
G
E
F
G
S
R
S
S
Q
A
S
R
Site 63
S737
A
G
E
F
G
S
R
S
S
Q
A
S
R
R
F
Site 64
S738
G
E
F
G
S
R
S
S
Q
A
S
R
R
F
G
Site 65
S741
G
S
R
S
S
Q
A
S
R
R
F
G
T
M
S
Site 66
T746
Q
A
S
R
R
F
G
T
M
S
S
M
S
G
A
Site 67
S748
S
R
R
F
G
T
M
S
S
M
S
G
A
D
D
Site 68
S749
R
R
F
G
T
M
S
S
M
S
G
A
D
D
T
Site 69
S751
F
G
T
M
S
S
M
S
G
A
D
D
T
V
Y
Site 70
T756
S
M
S
G
A
D
D
T
V
Y
M
E
Y
H
S
Site 71
Y758
S
G
A
D
D
T
V
Y
M
E
Y
H
S
S
R
Site 72
Y761
D
D
T
V
Y
M
E
Y
H
S
S
R
S
K
A
Site 73
S763
T
V
Y
M
E
Y
H
S
S
R
S
K
A
P
S
Site 74
S764
V
Y
M
E
Y
H
S
S
R
S
K
A
P
S
K
Site 75
S766
M
E
Y
H
S
S
R
S
K
A
P
S
K
H
V
Site 76
S770
S
S
R
S
K
A
P
S
K
H
V
H
P
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation