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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCL
Full Name:
Nucleolin
Alias:
C23; NUC; NUCL; Protein C23
Type:
DNA binding protein; Helicase; Nuclear receptor co-regulator; RNA binding protein
Mass (Da):
76614
Number AA:
710
UniProt ID:
P19338
International Prot ID:
IPI00604620
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005938
GO:0005730
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0032502
GO:0048646
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
P
K
E
V
E
E
D
S
E
D
E
E
M
S
E
Site 2
S34
D
S
E
D
E
E
M
S
E
D
E
E
D
D
S
Site 3
S41
S
E
D
E
E
D
D
S
S
G
E
E
V
V
I
Site 4
S42
E
D
E
E
D
D
S
S
G
E
E
V
V
I
P
Site 5
T59
K
G
K
K
A
A
A
T
S
A
K
K
V
V
V
Site 6
S67
S
A
K
K
V
V
V
S
P
T
K
K
V
A
V
Site 7
T69
K
K
V
V
V
S
P
T
K
K
V
A
V
A
T
Site 8
T76
T
K
K
V
A
V
A
T
P
A
K
K
A
A
V
Site 9
T84
P
A
K
K
A
A
V
T
P
G
K
K
A
A
A
Site 10
T92
P
G
K
K
A
A
A
T
P
A
K
K
T
V
T
Site 11
T97
A
A
T
P
A
K
K
T
V
T
P
A
K
A
V
Site 12
T99
T
P
A
K
K
T
V
T
P
A
K
A
V
T
T
Site 13
T105
V
T
P
A
K
A
V
T
T
P
G
K
K
G
A
Site 14
T106
T
P
A
K
A
V
T
T
P
G
K
K
G
A
T
Site 15
T113
T
P
G
K
K
G
A
T
P
G
K
A
L
V
A
Site 16
T121
P
G
K
A
L
V
A
T
P
G
K
K
G
A
A
Site 17
S145
K
N
A
K
K
E
D
S
D
E
E
E
D
D
D
Site 18
S153
D
E
E
E
D
D
D
S
E
E
D
E
E
D
D
Site 19
S184
A
A
A
A
A
P
A
S
E
D
E
D
D
E
D
Site 20
S206
D
D
D
E
E
D
D
S
E
E
E
A
M
E
T
Site 21
T213
S
E
E
E
A
M
E
T
T
P
A
K
G
K
K
Site 22
T214
E
E
E
A
M
E
T
T
P
A
K
G
K
K
A
Site 23
T301
K
K
Q
K
V
E
G
T
E
P
T
T
A
F
N
Site 24
T304
K
V
E
G
T
E
P
T
T
A
F
N
L
F
V
Site 25
T305
V
E
G
T
E
P
T
T
A
F
N
L
F
V
G
Site 26
S319
G
N
L
N
F
N
K
S
A
P
E
L
K
T
G
Site 27
S328
P
E
L
K
T
G
I
S
D
V
F
A
K
N
D
Site 28
Y351
G
M
T
R
K
F
G
Y
V
D
F
E
S
A
E
Site 29
S356
F
G
Y
V
D
F
E
S
A
E
D
L
E
K
A
Site 30
T367
L
E
K
A
L
E
L
T
G
L
K
V
F
G
N
Site 31
T394
K
K
E
R
D
A
R
T
L
L
A
K
N
L
P
Site 32
Y402
L
L
A
K
N
L
P
Y
K
V
T
Q
D
E
L
Site 33
T405
K
N
L
P
Y
K
V
T
Q
D
E
L
K
E
V
Site 34
S423
A
A
E
I
R
L
V
S
K
D
G
K
S
K
G
Site 35
S428
L
V
S
K
D
G
K
S
K
G
I
A
Y
I
E
Site 36
T445
T
E
A
D
A
E
K
T
F
E
E
K
Q
G
T
Site 37
T452
T
F
E
E
K
Q
G
T
E
I
D
G
R
S
I
Site 38
S458
G
T
E
I
D
G
R
S
I
S
L
Y
Y
T
G
Site 39
S460
E
I
D
G
R
S
I
S
L
Y
Y
T
G
E
K
Site 40
Y462
D
G
R
S
I
S
L
Y
Y
T
G
E
K
G
Q
Site 41
Y463
G
R
S
I
S
L
Y
Y
T
G
E
K
G
Q
N
Site 42
T464
R
S
I
S
L
Y
Y
T
G
E
K
G
Q
N
Q
Site 43
Y473
E
K
G
Q
N
Q
D
Y
R
G
G
K
N
S
T
Site 44
S479
D
Y
R
G
G
K
N
S
T
W
S
G
E
S
K
Site 45
T480
Y
R
G
G
K
N
S
T
W
S
G
E
S
K
T
Site 46
S482
G
G
K
N
S
T
W
S
G
E
S
K
T
L
V
Site 47
T487
T
W
S
G
E
S
K
T
L
V
L
S
N
L
S
Site 48
S491
E
S
K
T
L
V
L
S
N
L
S
Y
S
A
T
Site 49
S494
T
L
V
L
S
N
L
S
Y
S
A
T
E
E
T
Site 50
S496
V
L
S
N
L
S
Y
S
A
T
E
E
T
L
Q
Site 51
T498
S
N
L
S
Y
S
A
T
E
E
T
L
Q
E
V
Site 52
T510
Q
E
V
F
E
K
A
T
F
I
K
V
P
Q
N
Site 53
Y525
Q
N
G
K
S
K
G
Y
A
F
I
E
F
A
S
Site 54
S532
Y
A
F
I
E
F
A
S
F
E
D
A
K
E
A
Site 55
S542
D
A
K
E
A
L
N
S
C
N
K
R
E
I
E
Site 56
S563
E
L
Q
G
P
R
G
S
P
N
A
R
S
Q
P
Site 57
S568
R
G
S
P
N
A
R
S
Q
P
S
K
T
L
F
Site 58
T573
A
R
S
Q
P
S
K
T
L
F
V
K
G
L
S
Site 59
S580
T
L
F
V
K
G
L
S
E
D
T
T
E
E
T
Site 60
T584
K
G
L
S
E
D
T
T
E
E
T
L
K
E
S
Site 61
T587
S
E
D
T
T
E
E
T
L
K
E
S
F
D
G
Site 62
S591
T
E
E
T
L
K
E
S
F
D
G
S
V
R
A
Site 63
S595
L
K
E
S
F
D
G
S
V
R
A
R
I
V
T
Site 64
T602
S
V
R
A
R
I
V
T
D
R
E
T
G
S
S
Site 65
T606
R
I
V
T
D
R
E
T
G
S
S
K
G
F
G
Site 66
S608
V
T
D
R
E
T
G
S
S
K
G
F
G
F
V
Site 67
S609
T
D
R
E
T
G
S
S
K
G
F
G
F
V
D
Site 68
S619
F
G
F
V
D
F
N
S
E
E
D
A
K
A
A
Site 69
T641
E
I
D
G
N
K
V
T
L
D
W
A
K
P
K
Site 70
T707
H
K
P
Q
G
K
K
T
K
F
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation